{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:58:28Z","timestamp":1791187108265,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"52","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:00:00Z","timestamp":1601078400000},"content-version":"vor","delay-in-days":6144,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1074\/jbc.m308244200","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T21:32:55Z","timestamp":1071869575000},"page":"52810-52819","source":"Crossref","is-referenced-by-count":100,"title":["Fibrillogenic Amylin Evokes Islet \u03b2-Cell Apoptosis through Linked Activation of a Caspase Cascade and JNK1"],"prefix":"10.1016","volume":"278","author":[{"given":"Shaoping","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dragunow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garth J.S.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M308244200_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1210\/edrv-15-2-163","volume":"15","author":"Cooper","year":"1994","journal-title":"Endocrine Rev."},{"key":"10.1074\/jbc.M308244200_bib2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJM200008103430607","volume":"343","author":"Hoppener","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M308244200_bib3","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0140-6736(87)90825-7","volume":"2","author":"Clark","year":"1987","journal-title":"Lancet"},{"key":"10.1074\/jbc.M308244200_bib4","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1073\/pnas.84.23.8628","volume":"84","author":"Cooper","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M308244200_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-291X(91)91325-7","volume":"179","author":"Moore","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M308244200_bib6","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1172\/JCI114528","volume":"85","author":"Ogawa","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M308244200_bib7","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/368756a0","volume":"368","author":"Lorenzo","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M308244200_bib8","doi-asserted-by":"crossref","first-page":"7283","DOI":"10.1073\/pnas.93.14.7283","volume":"93","author":"Janson","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M308244200_bib9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0022-2836(02)01044-6","volume":"324","author":"Zhang","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M308244200_bib10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0014-5793(99)00894-7","volume":"455","author":"Zhang","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M308244200_bib11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/cbir.2000.0643","volume":"25","author":"Saafi","year":"2001","journal-title":"Cell Biol. Int."},{"key":"10.1074\/jbc.M308244200_bib12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2337\/diabetes.48.2.241","volume":"48","author":"Kahn","year":"1999","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M308244200_bib13","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/1097-0282(2001)60:6<438::AID-BIP10182>3.0.CO;2-A","volume":"60","author":"Kapurniotu","year":"2001","journal-title":"Biopolymers"},{"key":"10.1074\/jbc.M308244200_bib14","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1006\/jmbi.1999.3422","volume":"295","author":"Tenidis","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M308244200_bib15","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0022-2836(02)01377-3","volume":"326","author":"Green","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M308244200_bib16","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1006\/jsbi.2000.4268","volume":"130","author":"Goldsbury","year":"2000","journal-title":"J. Struct. Biol."},{"key":"10.1074\/jbc.M308244200_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/jmbi.1998.2299","volume":"285","author":"Goldsbury","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M308244200_bib18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/jsbi.1997.3858","volume":"119","author":"Goldsbury","year":"1997","journal-title":"J. Struct. Biol."},{"key":"10.1074\/jbc.M308244200_bib19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0167-4889(89)90220-6","volume":"1014","author":"Cooper","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M308244200_bib20","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1073\/pnas.87.13.5036","volume":"87","author":"Westermark","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M308244200_bib21","volume":"45","author":"Janes","year":"1996","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M308244200_bib22","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1006\/jmbi.1999.3286","volume":"294","author":"Nilsson","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M308244200_bib23","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1006\/jmbi.2001.4593","volume":"308","author":"Jaikaran","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M308244200_bib24","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0022-2836(02)00887-2","volume":"322","author":"Mazor","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M308244200_bib25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1530\/eje.0.1400069","volume":"140","author":"van Hulst","year":"1999","journal-title":"Eur. J. Endocrinol."},{"key":"10.1074\/jbc.M308244200_bib26","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1073\/pnas.93.8.3492","volume":"93","author":"Verchere","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M308244200_bib27","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1006\/bbrc.1999.1989","volume":"267","author":"Janciauskiene","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M308244200_bib28","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1074\/jbc.271.4.1988","volume":"271","author":"Mirzabekov","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308244200_bib29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1042\/bj3430053","volume":"343","author":"Bai","year":"1999","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M308244200_bib30","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2337\/diabetes.48.3.491","volume":"48","author":"Janson","year":"1999","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M308244200_bib31","doi-asserted-by":"crossref","first-page":"743","DOI":"10.2337\/diabetes.47.5.743","volume":"47","author":"Soeller","year":"1998","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M308244200_bib32","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1073\/pnas.90.3.786","volume":"90","author":"Vaux","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M308244200_bib33","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/348331a0","volume":"22","author":"Strasser","year":"1990","journal-title":"Nature"},{"key":"10.1074\/jbc.M308244200_bib34","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/356314a0","volume":"356","author":"Watanabe-Fukunaga","year":"1992","journal-title":"Nature"},{"key":"10.1074\/jbc.M308244200_bib35","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.biochem.69.1.217","volume":"69","author":"Strasser","year":"2000","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M308244200_bib36","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1126\/science.7878464","volume":"267","author":"Thompson","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.M308244200_bib37","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.281.5381.1312","volume":"281","author":"Thornberry","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M308244200_bib38","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1146\/annurev.biochem.68.1.383","volume":"68","author":"Earnshaw","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M308244200_bib39","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.cellbio.15.1.269","volume":"15","author":"Budihardjo","year":"1999","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1074\/jbc.M308244200_bib40","doi-asserted-by":"crossref","first-page":"478","DOI":"10.2337\/diabetes.48.3.478","volume":"48","author":"Yamada","year":"1999","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M308244200_bib41","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1046\/j.1432-1327.1998.2540439.x","volume":"254","author":"Schulzeosthoff","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M308244200_bib42","doi-asserted-by":"crossref","first-page":"29294","DOI":"10.1074\/jbc.M203342200","volume":"277","author":"Ohtsuka","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308244200_bib43","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0960-9822(07)00420-4","volume":"8","author":"Juo","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M308244200_bib44","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1126\/science.275.5296.90","volume":"275","author":"Ichijo","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M308244200_bib45","first-page":"281","volume":"6","author":"Gueli","year":"1987","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1074\/jbc.M308244200_bib46","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2337\/diabetes.50.1.77","volume":"50","author":"Bonny","year":"2001","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M308244200_bib47","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0165-6147(00)89093-8","volume":"16","author":"Poyner","year":"1995","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1074\/jbc.M308244200_bib48","doi-asserted-by":"crossref","first-page":"9662","DOI":"10.1073\/pnas.86.24.9662","volume":"86","author":"Roberts","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M308244200_bib49","doi-asserted-by":"crossref","first-page":"E859","DOI":"10.1152\/ajpcell.1997.273.3.C859","volume":"273","author":"Hettiarachchi","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M308244200_bib50","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/380723a0","volume":"380","author":"Enari","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M308244200_bib51","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0955-0674(98)80143-9","volume":"10","author":"Ip","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M308244200_bib52","first-page":"10","volume":"67","author":"Kumagae","year":"1999","journal-title":"Brain Res."},{"key":"10.1074\/jbc.M308244200_bib53","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1093\/emboj\/16.13.3805","volume":"16","author":"Longthorne","year":"1997","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M308244200_bib54","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/369156a0","volume":"369","author":"Kyriakis","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M308244200_bib55","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1002\/j.1460-2075.1996.tb00636.x","volume":"15","author":"Gupta","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M308244200_bib56","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.4049\/jimmunol.165.3.1337","volume":"165","author":"Villunger","year":"2000","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M308244200_bib57","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.2174\/1381612013397357","volume":"7","author":"Weyer","year":"2001","journal-title":"Curr. Pharm. Des."},{"key":"10.1074\/jbc.M308244200_bib58","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/(SICI)1096-9136(199707)14:7<547::AID-DIA390>3.0.CO;2-U","volume":"14","author":"Thompson","year":"1997","journal-title":"Diabetic Med."},{"key":"10.1074\/jbc.M308244200_bib59","first-page":"pA106","volume":"49","author":"Fineman","year":"2000","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M308244200_bib60","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1053\/meta.2002.32022","volume":"51","author":"Fineman","year":"2002","journal-title":"Metabol. Clin. Exp."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820752944?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820752944?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M308244200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T15:56:32Z","timestamp":1641398192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820752944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":60,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["S0021925820752944"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m308244200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}