{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:56:57Z","timestamp":1791194217797,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"49","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":6139,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1074\/jbc.m308529200","type":"journal-article","created":{"date-parts":[[2003,11,26]],"date-time":"2003-11-26T15:08:23Z","timestamp":1069859303000},"page":"48534-48545","source":"Crossref","is-referenced-by-count":279,"title":["Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation"],"prefix":"10.1016","volume":"278","author":[{"given":"Michael P.","family":"Murphy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim S.","family":"Echtay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances H.","family":"Blaikie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Asin-Cayuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena M.","family":"Cochem\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Buckingham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Hurrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri A.","family":"Svistunenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin A.J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin D.","family":"Brand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M308529200_bib1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0968-0004(00)01674-1","volume":"25","author":"Raha","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M308529200_bib2","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1126\/science.283.5407.1482","volume":"283","author":"Wallace","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.M308529200_bib3","doi-asserted-by":"crossref","first-page":"19771","DOI":"10.1073\/pnas.91.23.10771","volume":"91","author":"Shigenaga","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M308529200_bib4","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/415096a","volume":"415","author":"Echtay","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M308529200_bib5","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1093\/emboj\/cdg412","volume":"22","author":"Echtay","year":"2003","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M308529200_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1113\/eph8802502","volume":"88","author":"Nedergaard","year":"2003","journal-title":"Exp. Physiol."},{"key":"10.1074\/jbc.M308529200_bib7","author":"Brand","year":"2003","journal-title":"Biochem. Soc. Symp.,"},{"key":"10.1074\/jbc.M308529200_bib8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1017\/S0033583500005795","volume":"29","author":"Skulachev","year":"1996","journal-title":"Q. Rev. Biophys."},{"key":"10.1074\/jbc.M308529200_bib9","doi-asserted-by":"crossref","first-page":"8705","DOI":"10.1074\/jbc.M006938200","volume":"276","author":"Pecqueur","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308529200_bib10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/bj20021077","volume":"368","author":"Brand","year":"2002","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M308529200_bib11","doi-asserted-by":"crossref","first-page":"16258","DOI":"10.1074\/jbc.M910179199","volume":"275","author":"Vidal-Puig","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308529200_bib12","doi-asserted-by":"crossref","first-page":"47129","DOI":"10.1074\/jbc.M208262200","volume":"277","author":"Echtay","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308529200_bib13","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.1073\/pnas.0931245100","volume":"100","author":"Smith","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M308529200_bib14","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1074\/jbc.M009093200","volume":"276","author":"Kelso","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308529200_bib15","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1046\/j.1432-1327.1999.00543.x","volume":"263","author":"Smith","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M308529200_bib16","series-title":"Free Radicals: Biology and Detection by Spin Trapping","first-page":"442","author":"Rosen","year":"1999"},{"key":"10.1074\/jbc.M308529200_bib17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1006\/abio.1994.1085","volume":"217","author":"Pou","year":"1994","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M308529200_bib18","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0891-5849(00)00197-0","volume":"28","author":"Barclay","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1074\/jbc.M308529200_bib19","doi-asserted-by":"crossref","first-page":"17048","DOI":"10.1074\/jbc.M110797200","volume":"277","author":"Lin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308529200_bib20","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1021\/jo00035a020","volume":"57","author":"Hinton","year":"1992","journal-title":"J. Org. Chem."},{"key":"10.1074\/jbc.M308529200_bib21","series-title":"Reagents for Organic Synthesis,","first-page":"1276","volume":"Vol. 1","author":"Fieser","year":"1967"},{"key":"10.1074\/jbc.M308529200_bib22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1042\/bj2880439","volume":"288","author":"Davey","year":"1992","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M308529200_bib23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF01868720","volume":"49","author":"Kamo","year":"1979","journal-title":"J. Membr. Biol."},{"key":"10.1074\/jbc.M308529200_bib24","first-page":"39","author":"Brand","year":"1995"},{"key":"10.1074\/jbc.M308529200_bib25","series-title":"Subcellular Components: Preparation and Fractionation","first-page":"77","author":"Chappell","year":"1972"},{"key":"10.1074\/jbc.M308529200_bib26","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","volume":"177","author":"Gornall","year":"1949","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308529200_bib27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0076-6879(95)60139-2","volume":"260","author":"Glick","year":"1995","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M308529200_bib28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M308529200_bib29","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1042\/bj2430709","volume":"243","author":"Gutteridge","year":"1987","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M308529200_bib30","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1006\/abbi.2001.2694","volume":"397","author":"Welch","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.M308529200_bib31","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/S0021-9258(18)96082-5","volume":"242","author":"Rose","year":"1967","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308529200_bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0076-6879(02)49317-2","volume":"349","author":"Gardner","year":"2002","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M308529200_bib33","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1073\/pnas.91.3.1183","volume":"91","author":"Tribble","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M308529200_bib34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0076-6879(95)60127-9","volume":"260","author":"Walker","year":"1995","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M308529200_bib35","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1046\/j.1432-1033.2003.03660.x","volume":"270","author":"James","year":"2003","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M308529200_bib36","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1042\/bj2250399","volume":"225","author":"Brown","year":"1985","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M308529200_bib37","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1042\/bj2500477","volume":"250","author":"Hafner","year":"1988","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M308529200_bib38","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1042\/bj2650731","volume":"265","author":"Hafner","year":"1990","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M308529200_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-152513-2.50008-8","volume":"13","author":"Azzone","year":"1984","journal-title":"Curr. Top. Bioenerg."},{"key":"10.1074\/jbc.M308529200_bib40","author":"Smith","year":"2004","journal-title":"Methods Enzymol.,"},{"key":"10.1074\/jbc.M308529200_bib41","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.1074\/jbc.275.10.6741","volume":"275","author":"Atamna","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308529200_bib42","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0092-8674(01)00378-6","volume":"105","author":"Zhang","year":"2001","journal-title":"Cell"},{"key":"10.1074\/jbc.M308529200_bib43","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1021\/ar00072a005","volume":"14","author":"Sawyer","year":"1981","journal-title":"Acc. Chem. Res."},{"key":"10.1074\/jbc.M308529200_bib44","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF02042423","volume":"101","author":"Sridhar","year":"1986","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"10.1074\/jbc.M308529200_bib45","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1139\/v82-503","volume":"60","author":"Greenstock","year":"1982","journal-title":"Can. J. Chem."},{"key":"10.1074\/jbc.M308529200_bib46","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0003-2697(87)90222-3","volume":"165","author":"Halliwell","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M308529200_bib47","doi-asserted-by":"crossref","first-page":"18515","DOI":"10.1074\/jbc.272.30.18515","volume":"272","author":"Fridovich","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308529200_bib48","doi-asserted-by":"crossref","first-page":"14064","DOI":"10.1074\/jbc.275.19.14064","volume":"275","author":"Vasquez-Vivar","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308529200_bib49","first-page":"140","volume":"79","author":"Li","year":"1988","journal-title":"J. Magn. Reson."},{"key":"10.1074\/jbc.M308529200_bib50","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S0040-4039(00)91595-8","volume":"33","author":"Janzen","year":"1992","journal-title":"Tetrahedron Lett."},{"key":"10.1074\/jbc.M308529200_bib51","doi-asserted-by":"crossref","first-page":"15091","DOI":"10.1016\/S0021-9258(18)98591-1","volume":"266","author":"Aikens","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308529200_bib52","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1039\/p29770001770","volume":"13","author":"Ohto","year":"1977","journal-title":"J. Chem. Soc. Perkin Trans. II"},{"key":"10.1074\/jbc.M308529200_bib53","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Radic. Biol. Med."},{"key":"10.1074\/jbc.M308529200_bib54","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/10715769409147518","volume":"20","author":"Cooper","year":"1994","journal-title":"Free Radic. Res."},{"key":"10.1074\/jbc.M308529200_bib55","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1046\/j.1525-1373.1999.d01-140.x","volume":"222","author":"Floyd","year":"1999","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1074\/jbc.M308529200_bib56","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1089\/ars.1999.1.4-481","volume":"1","author":"Kotake","year":"1999","journal-title":"Antioxid. Redox Signal"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820756140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820756140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M308529200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T11:14:01Z","timestamp":1641381241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820756140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":56,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["S0021925820756140"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m308529200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}