{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:29:21Z","timestamp":1791080961209,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":6145,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1074\/jbc.m308537200","type":"journal-article","created":{"date-parts":[[2003,12,24]],"date-time":"2003-12-24T21:23:23Z","timestamp":1072301003000},"page":"251-258","source":"Crossref","is-referenced-by-count":95,"title":["Activation of Syndecan-1 Ectodomain Shedding by Staphylococcus aureus \u03b1-Toxin and \u03b2-Toxin"],"prefix":"10.1016","volume":"279","author":[{"given":"Pyong Woo","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichiro","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila J.","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Klagsbrun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M308537200_bib1","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.1021\/cr010202t","volume":"102","author":"Arribas","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1074\/jbc.M308537200_bib2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/bj3210265","volume":"321","author":"Hooper","year":"1997","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M308537200_bib3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj3000281","volume":"300","author":"Rose-John","year":"1994","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M308537200_bib4","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1242\/jcs.112.21.3603","volume":"112","author":"Schl\u00f6ndorff","year":"1999","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M308537200_bib5","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/370558a0","volume":"370","author":"McGeehan","year":"1994","journal-title":"Nature."},{"key":"10.1074\/jbc.M308537200_bib6","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/370218a0","volume":"370","author":"Mohler","year":"1994","journal-title":"Nature."},{"key":"10.1074\/jbc.M308537200_bib7","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.282.5392.1281","volume":"282","author":"Peschon","year":"1998","journal-title":"Science."},{"key":"10.1074\/jbc.M308537200_bib8","doi-asserted-by":"crossref","first-page":"48510","DOI":"10.1074\/jbc.M103488200","volume":"276","author":"Merlos-Suarez","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib9","doi-asserted-by":"crossref","first-page":"12838","DOI":"10.1074\/jbc.M112050200","volume":"277","author":"Sunnarborg","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib10","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1126\/science.1065412","volume":"294","author":"Ni","year":"2001","journal-title":"Science."},{"key":"10.1074\/jbc.M308537200_bib11","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1046\/j.1432-1327.2000.01278.x","volume":"267","author":"Althoff","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M308537200_bib12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1097-2765(00)80417-7","volume":"5","author":"Brou","year":"2000","journal-title":"Mol. Cell."},{"key":"10.1074\/jbc.M308537200_bib13","doi-asserted-by":"crossref","first-page":"27765","DOI":"10.1074\/jbc.273.43.27765","volume":"273","author":"Buxbaum","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4049\/jimmunol.167.1.123","volume":"167","author":"Shi","year":"2001","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M308537200_bib15","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1083\/jcb.148.4.811","volume":"148","author":"Fitzgerald","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M308537200_bib16","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1083\/jcb.153.5.893","volume":"153","author":"Kajita","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M308537200_bib17","doi-asserted-by":"crossref","first-page":"7260","DOI":"10.1093\/emboj\/17.24.7260","volume":"17","author":"Izumi","year":"1998","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M308537200_bib18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nm0102-41","volume":"8","author":"Lemjabbar","year":"2002","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M308537200_bib19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nm0102-35","volume":"8","author":"Asakura","year":"2002","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M308537200_bib20","doi-asserted-by":"crossref","first-page":"31730","DOI":"10.1074\/jbc.272.50.31730","volume":"272","author":"Suzuki","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1172\/JCI7091","volume":"105","author":"Haro","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M308537200_bib22","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/S0960-9822(00)80113-X","volume":"9","author":"Powell","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M308537200_bib23","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0002-9440(10)64318-0","volume":"162","author":"McGuire","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.M308537200_bib24","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0092-8674(02)01079-6","volume":"111","author":"Li","year":"2002","journal-title":"Cell."},{"key":"10.1074\/jbc.M308537200_bib25","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1074\/jbc.275.5.3057","volume":"275","author":"Park","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib26","doi-asserted-by":"crossref","first-page":"15490","DOI":"10.1074\/jbc.275.20.15490","volume":"275","author":"Gutwein","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib27","doi-asserted-by":"crossref","first-page":"28828","DOI":"10.1074\/jbc.274.40.28828","volume":"274","author":"Gechtman","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib28","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1093\/emboj\/18.24.6962","volume":"18","author":"Fan","year":"1999","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M308537200_bib29","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1128\/iai.64.9.3646-3651.1996","volume":"64","author":"Vollmer","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M308537200_bib30","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1128\/iai.64.10.4351-4355.1996","volume":"64","author":"Mattson","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M308537200_bib31","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1189\/jlb.68.6.865","volume":"68","author":"Walev","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"10.1074\/jbc.M308537200_bib32","doi-asserted-by":"crossref","first-page":"7882","DOI":"10.1073\/pnas.93.15.7882","volume":"93","author":"Walev","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1074\/jbc.M308537200_bib33","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1146\/annurev.biochem.68.1.729","volume":"68","author":"Bernfield","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M308537200_bib34","doi-asserted-by":"crossref","first-page":"29923","DOI":"10.1074\/jbc.R000008200","volume":"275","author":"Park","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib35","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/35075100","volume":"411","author":"Park","year":"2001","journal-title":"Nature."},{"key":"10.1074\/jbc.M308537200_bib36","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1056\/NEJM198405313102206","volume":"310","author":"Sheagren","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M308537200_bib37","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJM198405243102107","volume":"310","author":"Sheagren","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M308537200_bib38","series-title":"Gram-positive pathogens","first-page":"367","author":"Bohach","year":"2000"},{"key":"10.1074\/jbc.M308537200_bib39","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1126\/science.274.5294.1859","volume":"274","author":"Song","year":"1996","journal-title":"Science."},{"key":"10.1074\/jbc.M308537200_bib40","doi-asserted-by":"crossref","first-page":"11607","DOI":"10.1073\/pnas.94.21.11607","volume":"94","author":"Valeva","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M308537200_bib41","doi-asserted-by":"crossref","first-page":"24858","DOI":"10.1074\/jbc.272.40.24858","volume":"272","author":"Vandana","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib42","series-title":"Gram-positive Pathogens","author":"Arvidson","year":"2000"},{"key":"10.1074\/jbc.M308537200_bib43","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1046\/j.1365-2958.2003.03526.x","volume":"48","author":"Novick","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M308537200_bib44","doi-asserted-by":"crossref","first-page":"L207","DOI":"10.1152\/ajplung.00156.2001","volume":"282","author":"Rose","year":"2002","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1074\/jbc.M308537200_bib45","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev.immunol.15.1.371","volume":"15","author":"Bolen","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1074\/jbc.M308537200_bib46","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1093\/emboj\/16.6.1268","volume":"16","author":"Elenius","year":"1997","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M308537200_bib47","series-title":"Encyclopedia of Hormones","first-page":"235","volume":"2","author":"Nishi","year":"2003"},{"key":"10.1074\/jbc.M308537200_bib48","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1083\/jcb.151.2.209","volume":"151","author":"Tokumaru","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M308537200_bib49","doi-asserted-by":"crossref","first-page":"13561","DOI":"10.1074\/jbc.M209658200","volume":"278","author":"Zako","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib50","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1126\/science.274.5294.1855","volume":"274","author":"Hannun","year":"1996","journal-title":"Science."},{"key":"10.1074\/jbc.M308537200_bib51","doi-asserted-by":"crossref","first-page":"18617","DOI":"10.1074\/jbc.M300331200","volume":"278","author":"Fan","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib52","doi-asserted-by":"crossref","first-page":"19777","DOI":"10.1074\/jbc.M300466200","volume":"278","author":"Puglielli","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib53","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nm823","volume":"9","author":"Grassm\u00e9","year":"2003","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M308537200_bib54","doi-asserted-by":"crossref","first-page":"10702","DOI":"10.1074\/jbc.273.17.10702","volume":"273","author":"Kinnunen","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib55","doi-asserted-by":"crossref","first-page":"35291","DOI":"10.1074\/jbc.273.52.35291","volume":"273","author":"Ott","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib56","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0042-6822(67)90105-5","volume":"33","author":"Novick","year":"1967","journal-title":"Virology."},{"key":"10.1074\/jbc.M308537200_bib57","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0882-4010(86)90015-X","volume":"1","author":"O'Reilly","year":"1986","journal-title":"Microb. Pathog."},{"key":"10.1074\/jbc.M308537200_bib58","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1128\/iai.55.12.3103-3110.1987","volume":"55","author":"Patel","year":"1987","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M308537200_bib59","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/mpat.1997.0192","volume":"24","author":"Supersac","year":"1998","journal-title":"Microb. Pathog."},{"key":"10.1074\/jbc.M308537200_bib60","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1128\/IAI.67.3.1045-1049.1999","volume":"67","author":"Nilsson","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M308537200_bib61","doi-asserted-by":"crossref","first-page":"29969","DOI":"10.1074\/jbc.M102389200","volume":"276","author":"McAleese","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M308537200_bib62","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1002\/j.1460-2075.1993.tb06074.x","volume":"12","author":"Novick","year":"1993","journal-title":"EMBO J."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818528118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818528118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M308537200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T17:33:06Z","timestamp":1682616786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818528118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S0021925818528118"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m308537200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}