{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:54:02Z","timestamp":1792896842318,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":6057,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1074\/jbc.m311556200","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T02:05:53Z","timestamp":1079748353000},"page":"13095-13101","source":"Crossref","is-referenced-by-count":112,"title":["Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity"],"prefix":"10.1016","volume":"279","author":[{"given":"Qing","family":"Huai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharron H.","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie D.","family":"Corbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengming","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M311556200_bib1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1006\/frne.1999.0193","volume":"21","author":"Antoni","year":"2000","journal-title":"Front. Neuroendocrinol."},{"key":"10.1074\/jbc.M311556200_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(98)00009-4","volume":"56","author":"Pelligrino","year":"1998","journal-title":"Prog. Neurobiol."},{"key":"10.1074\/jbc.M311556200_bib3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/1097-4652(200009)184:3<409::AID-JCP16>3.0.CO;2-K","volume":"184","author":"Carvajal","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"10.1074\/jbc.M311556200_bib4","first-page":"375","volume":"52","author":"Lucas","year":"2000","journal-title":"Pharmacol. Rev."},{"key":"10.1074\/jbc.M311556200_bib5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0898-6568(01)00283-2","volume":"14","author":"Klein","year":"2002","journal-title":"Cell. Signal."},{"key":"10.1074\/jbc.M311556200_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1749-6632.2002.tb04326.x","volume":"968","author":"Chin","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1074\/jbc.M311556200_bib7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0898-6568(95)00017-J","volume":"7","author":"Manganiello","year":"1995","journal-title":"Cell. Signal."},{"key":"10.1074\/jbc.M311556200_bib8","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0165-6147(96)10035-3","volume":"17","author":"M\u00fcller","year":"1996","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1074\/jbc.M311556200_bib9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1054-3589(08)60128-3","volume":"44","author":"Houslay","year":"1998","journal-title":"Adv. Pharmacol."},{"key":"10.1074\/jbc.M311556200_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20021698","volume":"370","author":"Houslay","year":"2003","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M311556200_bib11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1164\/ajrccm.157.2.9708012","volume":"157","author":"Torphy","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1074\/jbc.M311556200_bib12","doi-asserted-by":"crossref","first-page":"13729","DOI":"10.1074\/jbc.274.20.13729","volume":"274","author":"Corbin","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311556200_bib13","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0955-0674(99)00073-3","volume":"12","author":"Soderling","year":"2000","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M311556200_bib14","first-page":"1","volume":"65","author":"Francis","year":"2001","journal-title":"Prog. Nucleic Acids Res. Mol. Biol."},{"key":"10.1074\/jbc.M311556200_bib15","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1074\/jbc.R200029200","volume":"278","author":"Conti","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311556200_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1043-2760(01)00523-9","volume":"13","author":"Mehats","year":"2002","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1074\/jbc.M311556200_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/abbi.1995.1429","volume":"322","author":"Manganiello","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.M311556200_bib18","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1042\/bst0241010","volume":"24","author":"Degerman","year":"1996","journal-title":"Biochem. Soc. Trans."},{"key":"10.1074\/jbc.M311556200_bib19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1742-1241.2002.tb11296.x","volume":"56","author":"Corbin","year":"2002","journal-title":"Int. J. Clin. Pract."},{"key":"10.1074\/jbc.M311556200_bib20","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1517\/13543784.9.5.963","volume":"9","author":"Movsesian","year":"2000","journal-title":"Exp. Opin. Investig. Drugs"},{"key":"10.1074\/jbc.M311556200_bib21","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s003450100221","volume":"19","author":"Truss","year":"2001","journal-title":"World J. Urol."},{"key":"10.1074\/jbc.M311556200_bib22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1527-3466.2001.tb00076.x","volume":"19","author":"Liu","year":"2001","journal-title":"Cardiovasc. Drug Rev."},{"key":"10.1074\/jbc.M311556200_bib23","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S1367-5931(00)00224-6","volume":"5","author":"Huang","year":"2001","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1074\/jbc.M311556200_bib24","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrd893","volume":"1","author":"Rotella","year":"2002","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1074\/jbc.M311556200_bib25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-3-0348-8735-9_5","volume":"53","author":"Barnette","year":"1999","journal-title":"Prog. Drug Res."},{"key":"10.1074\/jbc.M311556200_bib26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0162-3109(00)00185-5","volume":"47","author":"Souness","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1074\/jbc.M311556200_bib27","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/00063198-200003000-00014","volume":"6","author":"Barnette","year":"2000","journal-title":"Curr. Opin. Pulmonary Med."},{"key":"10.1074\/jbc.M311556200_bib28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0223-5234(00)00179-3","volume":"35","author":"Piaz","year":"2000","journal-title":"Eur. J. Med. Chem."},{"key":"10.1074\/jbc.M311556200_bib29","first-page":"48","volume":"57","author":"Giembycz","year":"2002","journal-title":"Monaldi Arch. Chest Dis."},{"key":"10.1074\/jbc.M311556200_bib30","doi-asserted-by":"crossref","first-page":"S192","DOI":"10.1378\/chest.121.5_suppl.192S","volume":"121","author":"Sturton","year":"2002","journal-title":"Chest"},{"key":"10.1074\/jbc.M311556200_bib31","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1126\/science.288.5472.1822","volume":"288","author":"Xu","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M311556200_bib32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0014-5793(02)03396-3","volume":"530","author":"Lee","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M311556200_bib33","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0969-2126(03)00123-0","volume":"11","author":"Huai","year":"2003","journal-title":"Structure"},{"key":"10.1074\/jbc.M311556200_bib34","doi-asserted-by":"crossref","first-page":"13200","DOI":"10.1021\/bi034653e","volume":"42","author":"Huai","year":"2003","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M311556200_bib35","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nature01914","volume":"425","author":"Sung","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M311556200_bib36","doi-asserted-by":"crossref","first-page":"24613","DOI":"10.1074\/jbc.274.49.34613","volume":"274","author":"Fink","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311556200_bib37","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M311556200_bib38","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","volume":"54","author":"Br\u00fcnger","year":"1998","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M311556200_bib39","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0076-6879(97)76079-8","volume":"276","author":"Navaza","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M311556200_bib40","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","volume":"47","author":"Jones","year":"1991","journal-title":"Acta Crystallogr. Sect. A"},{"key":"10.1074\/jbc.M311556200_bib41","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","volume":"50","author":"Collaborative Computational Project Number 4","year":"1994","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M311556200_bib42","doi-asserted-by":"crossref","first-page":"9591","DOI":"10.1021\/bi000392m","volume":"39","author":"Francis","year":"2000","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M311556200_bib43","doi-asserted-by":"crossref","first-page":"22477","DOI":"10.1016\/S0021-9258(17)31669-1","volume":"269","author":"Francis","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311556200_bib44","first-page":"597","volume":"6","author":"Beavo","year":"1970","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M311556200_bib45","series-title":"Phosphodiesterase Inhibitors","first-page":"135","author":"Sekhar","year":"1996"},{"key":"10.1074\/jbc.M311556200_bib46","series-title":"Phosphodiesterase Inhibitors","first-page":"161","author":"Alvarez","year":"1996"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819642572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819642572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M311556200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T18:51:30Z","timestamp":1705085490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819642572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":46,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0021925819642572"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m311556200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}