{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:11:53Z","timestamp":1793203913989,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":6057,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1074\/jbc.m314124200","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T02:05:53Z","timestamp":1079748353000},"page":"13256-13264","source":"Crossref","is-referenced-by-count":507,"title":["Oxidative Modifications and Down-regulation of Ubiquitin Carboxyl-terminal Hydrolase L1 Associated with Idiopathic Parkinson's and Alzheimer's Diseases"],"prefix":"10.1016","volume":"279","author":[{"given":"Joungil","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan I.","family":"Levey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan T.","family":"Weintraub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard D.","family":"Rees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marla","family":"Gearing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lih-Shen","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M314124200_bib1","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1056\/NEJM2003ra020003","volume":"348","author":"Nussbaum","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M314124200_bib2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1568-1637(03)00025-4","volume":"2","author":"Layfield","year":"2003","journal-title":"Ageing Res. Rev."},{"key":"10.1074\/jbc.M314124200_bib3","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1087753","volume":"302","author":"Dawson","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M314124200_bib4","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S1357-2725(02)00043-2","volume":"34","author":"van Leeuwen","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1074\/jbc.M314124200_bib5","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0891-5849(02)00780-3","volume":"32","author":"Beal","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1074\/jbc.M314124200_bib6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1172\/JCI200317638","volume":"111","author":"Ischiropoulos","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M314124200_bib7","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0891-5849(02)00804-3","volume":"32","author":"Giasson","year":"2002","journal-title":"Free Radic. Biol. Med."},{"issue":"Suppl. 3","key":"10.1074\/jbc.M314124200_bib8","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1002\/ana.10483","volume":"53","author":"Jenner","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M314124200_bib9","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"10.1074\/jbc.M314124200_bib10","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1212\/WNL.45.11.1985","volume":"45","author":"Gearing","year":"1995","journal-title":"Neurology"},{"key":"10.1074\/jbc.M314124200_bib11","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/S0006-291X(02)00420-5","volume":"293","author":"Choi","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M314124200_bib12","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/1615-9861(200107)1:7<829::AID-PROT829>3.0.CO;2-R","volume":"1","author":"Conrad","year":"2001","journal-title":"Proteomics"},{"key":"10.1074\/jbc.M314124200_bib13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/26652","volume":"395","author":"Leroy","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M314124200_bib14","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0531-5565(01)00135-8","volume":"36","author":"Levine","year":"2001","journal-title":"Exp. Gerontol."},{"key":"10.1074\/jbc.M314124200_bib15","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0891-5849(02)00914-0","volume":"33","author":"Castegna","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1074\/jbc.M314124200_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1469-7793.2001.0001j.x","volume":"531","author":"Hoshi","year":"2001","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M314124200_bib17","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/abbi.2001.2664","volume":"397","author":"Weissbach","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.M314124200_bib18","doi-asserted-by":"crossref","first-page":"15036","DOI":"10.1073\/pnas.93.26.15036","volume":"93","author":"Levine","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M314124200_bib19","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1126\/science.2530630","volume":"246","author":"Wilkinson","year":"1989","journal-title":"Science"},{"key":"10.1074\/jbc.M314124200_bib20","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1046\/j.1471-4159.1999.0731660.x","volume":"73","author":"Gabbita","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M314124200_bib21","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0955-0674(03)00002-4","volume":"15","author":"Finkel","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M314124200_bib22","doi-asserted-by":"crossref","first-page":"15407","DOI":"10.1021\/bi992025k","volume":"38","author":"Claiborne","year":"1999","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1074\/jbc.M314124200_bib23","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1021\/bi960099f","volume":"35","author":"Larsen","year":"1996","journal-title":"Biochemistry (Mosc)"},{"key":"10.1074\/jbc.M314124200_bib24","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1021\/bi972274d","volume":"37","author":"Larsen","year":"1998","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1074\/jbc.M314124200_bib25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/scdb.2000.0164","volume":"11","author":"Wilkinson","year":"2000","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1074\/jbc.M314124200_bib26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/12647","volume":"23","author":"Saigoh","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M314124200_bib27","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0006-291X(03)00555-2","volume":"304","author":"Nishikawa","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M314124200_bib28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0092-8674(02)01012-7","volume":"111","author":"Liu","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M314124200_bib29","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nrn961","volume":"3","author":"Hegde","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1074\/jbc.M314124200_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0006-8993(95)00729-A","volume":"695","author":"Ichihara","year":"1995","journal-title":"Brain Res."},{"key":"10.1074\/jbc.M314124200_bib31","first-page":"163","volume":"2","author":"Wu","year":"1996","journal-title":"Alzheimer's Res."},{"key":"10.1074\/jbc.M314124200_bib32","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1093\/hmg\/ddg211","volume":"12","author":"Osaka","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M314124200_bib33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/path.1711610210","volume":"161","author":"Lowe","year":"1990","journal-title":"J. Pathol."},{"key":"10.1074\/jbc.M314124200_bib34","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0166-2236(98)01337-X","volume":"21","author":"Spillantini","year":"1998","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M314124200_bib35","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-3-7091-6467-9_15","volume":"53","author":"Iqbal","year":"1998","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1074\/jbc.M314124200_bib36","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1146\/annurev.neuro.24.1.1121","volume":"24","author":"Lee","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1074\/jbc.M314124200_bib37","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1471-4914(02)02440-1","volume":"8","author":"Ingram","year":"2002","journal-title":"Trends Mol. Med."},{"key":"10.1074\/jbc.M314124200_bib38","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.1074\/jbc.M305838200","volume":"279","author":"Shimura","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M314124200_bib39","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/bms.1200111109","volume":"11","author":"Roepstorff","year":"1984","journal-title":"Biomed. Mass Spectrom."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819642754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819642754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M314124200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T02:26:13Z","timestamp":1641176773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819642754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":39,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0021925819642754"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m314124200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}