{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:03:41Z","timestamp":1791191021887,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":5965,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1074\/jbc.m402602200","type":"journal-article","created":{"date-parts":[[2004,7,2]],"date-time":"2004-07-02T19:08:46Z","timestamp":1088795326000},"page":"29598-29605","source":"Crossref","is-referenced-by-count":45,"title":["The Nucleoside Derivative 5\u2032-O-Trityl-inosine (KIN59) Suppresses Thymidine Phosphorylase-triggered Angiogenesis via a Noncompetitive Mechanism of Action"],"prefix":"10.1016","volume":"279","author":[{"given":"Sandra","family":"Liekens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Isabel","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Ribatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"De Clercq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Jos\u00e9","family":"Camarasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Jes\u00fas","family":"P\u00e9rez-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Balzarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M402602200_bib1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0006-2952(00)00529-3","volume":"61","author":"Liekens","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M402602200_bib2","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1016\/0006-2952(83)90307-6","volume":"32","author":"Desgranges","year":"1983","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M402602200_bib3","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0006-291X(05)80025-7","volume":"184","author":"Usuki","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M402602200_bib4","first-page":"1687","volume":"55","author":"Miyadera","year":"1995","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M402602200_bib5","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/338557a0","volume":"338","author":"Ishikawa","year":"1989","journal-title":"Nature"},{"key":"10.1074\/jbc.M402602200_bib6","first-page":"6298","volume":"60","author":"Brown","year":"2000","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M402602200_bib7","first-page":"527","volume":"63","author":"Hotchkiss","year":"2003","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M402602200_bib8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/ijc.2910640202","volume":"64","author":"Toi","year":"1995","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M402602200_bib9","first-page":"201","volume":"12","author":"Hata","year":"1998","journal-title":"Obstet. Gynecol."},{"key":"10.1074\/jbc.M402602200_bib10","first-page":"5037","volume":"59","author":"Matsuura","year":"1999","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M402602200_bib11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0959-8049(99)00201-4","volume":"36","author":"Seki","year":"2000","journal-title":"Eur. J. Cancer"},{"key":"10.1074\/jbc.M402602200_bib12","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1046\/j.1440-1827.2001.01184.x","volume":"51","author":"Okamoto","year":"2001","journal-title":"Pathol. Int."},{"key":"10.1074\/jbc.M402602200_bib13","first-page":"1911","volume":"59","author":"Matsushita","year":"1999","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M402602200_bib14","doi-asserted-by":"crossref","first-page":"14016","DOI":"10.1016\/S0021-9258(18)77450-4","volume":"265","author":"Walter","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M402602200_bib15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.str.2003.11.018","volume":"12","author":"Norman","year":"2004","journal-title":"Structure"},{"key":"10.1074\/jbc.M402602200_bib16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0014-5793(98)01271-X","volume":"438","author":"Balzarini","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M402602200_bib17","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1021\/jm9911377","volume":"43","author":"Esteban-Gamboa","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M402602200_bib18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0014-5793(00)02101-3","volume":"483","author":"Balzarini","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M402602200_bib19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0014-5793(01)03233-1","volume":"510","author":"Liekens","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M402602200_bib20","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1021\/jo01020a510","volume":"30","author":"Muramatsu","year":"1965","journal-title":"J. Org. Chem."},{"key":"10.1074\/jbc.M402602200_bib21","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1021\/jo00270a036","volume":"54","author":"Chu","year":"1989","journal-title":"J. Org. Chem."},{"key":"10.1074\/jbc.M402602200_bib22","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/01.ATV.17.3.454","volume":"17","author":"Bastaki","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1074\/jbc.M402602200_bib23","first-page":"5057","volume":"61","author":"Liekens","year":"2001","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M402602200_bib24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1159\/000159256","volume":"34","author":"Ribatti","year":"1997","journal-title":"J. Vasc. Res."},{"key":"10.1074\/jbc.M402602200_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3340001","volume":"334","author":"Brown","year":"1998","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M402602200_bib26","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/368198a0","volume":"368","author":"Haraguchi","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M402602200_bib27","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1073\/pnas.92.4.998","volume":"92","author":"Moghaddam","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M402602200_bib28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/sj.bjp.0705216","volume":"139","author":"Sengupta","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1074\/jbc.M402602200_bib29","doi-asserted-by":"crossref","first-page":"19272","DOI":"10.1074\/jbc.M212670200","volume":"278","author":"Hotchkiss","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M402602200_bib30","first-page":"1641","volume":"152","author":"Stevenson","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.M402602200_bib31","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0006-291X(02)00662-9","volume":"295","author":"Mori","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M402602200_bib32","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0006-291X(02)03034-6","volume":"301","author":"Ikeda","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M402602200_bib33","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1006\/bbrc.1998.9852","volume":"253","author":"Kitazono","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M402602200_bib34","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1006\/bbrc.2002.6432","volume":"291","author":"Ikeda","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M402602200_bib35","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0969-2126(98)00145-2","volume":"6","author":"Pugmire","year":"1998","journal-title":"Structure"},{"key":"10.1074\/jbc.M402602200_bib36","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/(SICI)1097-0134(19991101)37:2<242::AID-PROT9>3.0.CO;2-5","volume":"37","author":"Rick","year":"1999","journal-title":"Proteins"},{"key":"10.1074\/jbc.M402602200_bib37","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/bi034793o","volume":"43","author":"Mendieta","year":"2004","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M402602200_bib38","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1021\/jm000037u","volume":"43","author":"Focher","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M402602200_bib39","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S0006-2952(01)00783-3","volume":"62","author":"Klein","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M402602200_bib40","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1021\/jm020964w","volume":"46","author":"Cole","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M402602200_bib41","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1582-4934.2002.tb00524.x","volume":"6","author":"Ribatti","year":"2002","journal-title":"J. Cell. Mol. Med."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819712149?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819712149?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M402602200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T19:05:54Z","timestamp":1641236754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819712149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":41,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0021925819712149"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m402602200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}