{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:22:18Z","timestamp":1791123738795,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"25","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:00:00Z","timestamp":1601078400000},"content-version":"vor","delay-in-days":5961,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2004,6]]},"DOI":"10.1074\/jbc.m402989200","type":"journal-article","created":{"date-parts":[[2004,6,11]],"date-time":"2004-06-11T20:23:29Z","timestamp":1086985409000},"page":"26066-26073","source":"Crossref","is-referenced-by-count":193,"title":["Identification and Characterization of the First Class of Potent Bacterial Acetyl-CoA Carboxylase Inhibitors with Antibacterial Activity"],"prefix":"10.1016","volume":"279","author":[{"given":"Christoph","family":"Freiberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina A.","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Schiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lampe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Pohlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Raabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"H\u00e4bich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Ziegelbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M402989200_bib1","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1073\/pnas.94.11.5588","volume":"94","author":"Chirala","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M402989200_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0005-2760(96)00056-2","volume":"1302","author":"Rock","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M402989200_bib3","first-page":"612","author":"Cronan","year":"1996"},{"key":"10.1074\/jbc.M402989200_bib4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1146\/annurev.micro.55.1.305","volume":"55","author":"Campbell","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.M402989200_bib5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0163-7827(01)00012-1","volume":"40","author":"Heath","year":"2001","journal-title":"Prog. Lipid Res."},{"key":"10.1074\/jbc.M402989200_bib6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1359-6446(01)01774-3","volume":"6","author":"Payne","year":"2001","journal-title":"Drug Discov. Today"},{"key":"10.1074\/jbc.M402989200_bib7","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/28970","volume":"394","author":"McMurry","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M402989200_bib8","doi-asserted-by":"crossref","first-page":"30316","DOI":"10.1074\/jbc.273.46.30316","volume":"273","author":"Heath","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M402989200_bib9","doi-asserted-by":"crossref","first-page":"6551","DOI":"10.1074\/jbc.M007101200","volume":"276","author":"Price","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M402989200_bib10","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1128\/JB.183.10.3032-3040.2001","volume":"183","author":"Schujman","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M402989200_bib11","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1042\/bst0301050","volume":"30","author":"Marrakchi","year":"2001","journal-title":"Biochem. Soc. Trans."},{"key":"10.1074\/jbc.M402989200_bib12","doi-asserted-by":"crossref","first-page":"30024","DOI":"10.1074\/jbc.M101769200","volume":"276","author":"Khandekar","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M402989200_bib13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1021\/jm025571b","volume":"46","author":"Daines","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M402989200_bib14","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1128\/AAC.46.5.1310-1318.2002","volume":"46","author":"He","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M402989200_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/35018162","volume":"406","author":"Heath","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M402989200_bib16","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1021\/jm020050+","volume":"45","author":"Miller","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M402989200_bib17","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1128\/AAC.46.10.3118-3124.2002","volume":"46","author":"Payne","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M402989200_bib18","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1021\/jm0204035","volume":"46","author":"Seefeld","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M402989200_bib19","doi-asserted-by":"crossref","first-page":"28593","DOI":"10.1074\/jbc.M004756200","volume":"275","author":"Davis","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M402989200_bib20","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1128\/JB.183.4.1499-1503.2001","volume":"183","author":"Davis","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M402989200_bib21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S1534-5807(03)00123-0","volume":"4","author":"Schujman","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1074\/jbc.M402989200_bib22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0163-7827(02)00007-3","volume":"41","author":"Cronan","year":"2002","journal-title":"Prog. Lipid Res."},{"key":"10.1074\/jbc.M402989200_bib23","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0005-2760(76)90022-9","volume":"450","author":"Fall","year":"1976","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M402989200_bib24","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1006\/bbrc.2002.6576","volume":"291","author":"Levert","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M402989200_bib25","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1006\/bbrc.1999.1844","volume":"266","author":"Blanchard","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M402989200_bib26","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1021\/jo00087a020","volume":"59","author":"Needham","year":"1994","journal-title":"J. Org. Chem."},{"key":"10.1074\/jbc.M402989200_bib27","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1021\/ja00248a055","volume":"109","author":"Fredenhagen","year":"1987","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M402989200_bib28","first-page":"7","volume":"78","author":"Oclarit","year":"1994","journal-title":"Microbios"},{"key":"10.1074\/jbc.M402989200_bib29","series-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","year":"2001"},{"key":"10.1074\/jbc.M402989200_bib30","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1039\/a804662j","volume":"17","author":"Davies","year":"1998","journal-title":"J. Chem. Soc. Perkin Trans. I"},{"key":"10.1074\/jbc.M402989200_bib31","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1128\/jb.81.5.741-746.1961","volume":"81","author":"Anagnostopoulos","year":"1961","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M402989200_bib32","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1099\/00221287-147-7-1783","volume":"147","author":"Haas","year":"2001","journal-title":"Microbiology"},{"key":"10.1074\/jbc.M402989200_bib33","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1073\/pnas.97.4.1444","volume":"97","author":"Abu-Elheiga","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M402989200_bib34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2958.1995.tb02390.x","volume":"16","author":"Ma","year":"1995","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M402989200_bib35","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1128\/AAC.42.2.394","volume":"42","author":"Schweizer","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M402989200_bib36","doi-asserted-by":"crossref","first-page":"19140","DOI":"10.1074\/jbc.273.30.19140","volume":"273","author":"Blanchard","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M402989200_bib37","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1074\/jbc.271.4.1833","volume":"271","author":"Heath","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M402989200_bib38","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M402989200_bib39","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1021\/bi982660a","volume":"38","author":"Blanchard","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M402989200_bib40","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0076-6879(75)35135-5","volume":"35","author":"Guchhait","year":"1975","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M402989200_bib41","first-page":"96","author":"Harwood","year":"1990"},{"key":"10.1074\/jbc.M402989200_bib42","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1016\/S0021-9258(18)68807-6","volume":"263","author":"Thampy","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M402989200_bib43","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0304-4165(82)90354-3","volume":"715","author":"Tipper","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M402989200_bib44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0003-2697(86)90058-8","volume":"153","author":"Hosokawa","year":"1986","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M402989200_bib45","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1039\/c39890000299","volume":"5","author":"McWorther","year":"1989","journal-title":"J. Chem. Soc. Chem. Commun."},{"key":"10.1074\/jbc.M402989200_bib46","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1016\/S0040-4039(00)92179-8","volume":"32","author":"Rao","year":"1991","journal-title":"Tetrahedron Lett."},{"key":"10.1074\/jbc.M402989200_bib47","doi-asserted-by":"crossref","first-page":"270","DOI":"10.7164\/antibiotics.50.270","volume":"50","author":"Singh","year":"1997","journal-title":"J. Antibiot. (Tokyo)"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820855835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820855835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M402989200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T22:04:01Z","timestamp":1641420241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820855835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":47,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["S0021925820855835"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m402989200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}