{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:07:50Z","timestamp":1788448070646,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","issue":"37","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"vor","delay-in-days":5890,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1074\/jbc.m403140200","type":"journal-article","created":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T01:56:07Z","timestamp":1088646967000},"page":"38294-38302","source":"Crossref","is-referenced-by-count":114,"title":["Melatonin, an Endogenous-specific Inhibitor of Estrogen Receptor \u03b1 via Calmodulin"],"prefix":"10.1016","volume":"279","author":[{"given":"Beatriz","family":"del R\u00edo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana M. Garc\u00eda","family":"Pedrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Mart\u00ednez-Campa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Zuazua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro S.","family":"Lazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M403140200_bib1","series-title":"The Pineal Gland and Cancer","first-page":"221","author":"S\u00e1nchez-Barcel\u00f3","year":"1988"},{"key":"10.1074\/jbc.M403140200_bib2","series-title":"The Pineal Gland","first-page":"253","author":"Blask","year":"1984"},{"key":"10.1074\/jbc.M403140200_bib3","series-title":"Melatonin Clinical Perspectives","first-page":"128","author":"Blask","year":"1988"},{"key":"10.1074\/jbc.M403140200_bib4","series-title":"Pineal Update: From Molecular Mechanisms to Clinical Implications","first-page":"361","author":"S\u00e1nchez-Barcel\u00f3","year":"1997"},{"key":"10.1074\/jbc.M403140200_bib5","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0959-8049(05)80087-5","volume":"28","author":"Coleman","year":"1992","journal-title":"Eur. J. Cancer"},{"key":"10.1074\/jbc.M403140200_bib6","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1093\/jnci\/93.20.1563","volume":"93","author":"Schernhammer","year":"2001","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1074\/jbc.M403140200_bib7","first-page":"259","volume":"3","author":"Blask","year":"1989"},{"key":"10.1074\/jbc.M403140200_bib8","first-page":"103","volume":"15","author":"Reiter","year":"1993","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1074\/jbc.M403140200_bib9","first-page":"4740","volume":"54","author":"Maestroni","year":"1994","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M403140200_bib10","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.4049\/jimmunol.153.6.2671","volume":"153","author":"Morrey","year":"1994","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M403140200_bib11","first-page":"6121","volume":"48","author":"Hill","year":"1988","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M403140200_bib12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1600-079X.1991.tb00007.x","volume":"10","author":"Cos","year":"1991","journal-title":"J. Pineal. Res."},{"key":"10.1074\/jbc.M403140200_bib13","first-page":"4383","volume":"58","author":"Cos","year":"1998","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M403140200_bib14","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1096\/fasebj.13.8.857","volume":"13","author":"Rato","year":"1999","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M403140200_bib15","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1021\/jm9505472","volume":"39","author":"Hardcastle","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M403140200_bib16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0006-8993(91)90146-M","volume":"557","author":"Benitez-King","year":"1991","journal-title":"Brain Res."},{"key":"10.1074\/jbc.M403140200_bib17","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1096\/fasebj.12.13.1401","volume":"12","author":"Romero","year":"1998","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M403140200_bib18","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1210\/mend.16.5.0830","volume":"16","author":"Garcia Pedrero","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M403140200_bib19","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1210\/en.2002-0027","volume":"144","author":"Garcia Pedrero","year":"2003","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M403140200_bib20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0014-5793(98)00079-9","volume":"423","author":"Ogawa","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M403140200_bib21","first-page":"659","volume":"9","author":"McDonnell","year":"1995","journal-title":"Mol Endocrinol."},{"key":"10.1074\/jbc.M403140200_bib22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/abio.1993.1170","volume":"210","author":"Frangioni","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M403140200_bib23","doi-asserted-by":"crossref","first-page":"10009","DOI":"10.1073\/pnas.91.21.10009","volume":"91","author":"Cavailles","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M403140200_bib24","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.277.5331.1508","volume":"277","author":"Paech","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M403140200_bib25","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1006\/bbrc.1995.1401","volume":"208","author":"Bouhoute","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M403140200_bib26","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1210\/mend.12.7.0133","volume":"7","author":"Philips","year":"1998","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M403140200_bib27","first-page":"634","volume":"14","author":"Bollig","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M403140200_bib28","first-page":"2010","volume":"12","author":"Hall","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M403140200_bib29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0014-5793(98)01637-8","volume":"442","author":"Osawa","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M403140200_bib30","doi-asserted-by":"crossref","first-page":"17354","DOI":"10.1074\/jbc.M010238200","volume":"276","author":"Li","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M403140200_bib31","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1210\/mend.11.9.9983","volume":"9","author":"Lazennec","year":"1997","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M403140200_bib32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1600-079X.1995.tb00146.x","volume":"18","author":"Molis","year":"1994","journal-title":"J. Pineal. Res."},{"key":"10.1074\/jbc.M403140200_bib33","first-page":"669","volume":"75","author":"Wilson","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1074\/jbc.M403140200_bib34","first-page":"1681","volume":"8","author":"Molis","year":"1994","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M403140200_bib35","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/bjc.1995.164","volume":"71","author":"Lissoni","year":"1995","journal-title":"Br. J. Cancer."},{"key":"10.1074\/jbc.M403140200_bib36","doi-asserted-by":"crossref","unstructured":"Castoria, G., Migliaccio, A., Nola E., and Auricchio, F. (1988) 2, 167\u2013174","DOI":"10.1210\/mend-2-2-167"},{"key":"10.1074\/jbc.M403140200_bib37","first-page":"5367","volume":"58","author":"Pujol","year":"1998","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M403140200_bib38","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/bj3470211","volume":"347","author":"Matsushima","year":"2000","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M403140200_bib39","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1074\/jbc.M210708200","volume":"278","author":"Li","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M403140200_bib40","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/39645","volume":"389","author":"Brzozowski","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M403140200_bib41","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1210\/edrv-17-6-587","volume":"6","author":"Beato","year":"1996","journal-title":"Endocr. Rev."},{"key":"10.1074\/jbc.M403140200_bib42","doi-asserted-by":"crossref","first-page":"10069","DOI":"10.1073\/pnas.93.19.10069","volume":"93","author":"McInerney","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M403140200_bib43","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/bcr30","volume":"58","author":"Leygue","year":"1999","journal-title":"Breast Cancer Res."},{"key":"10.1074\/jbc.M403140200_bib44","first-page":"245","volume":"60","author":"Foley","year":"2000","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M403140200_bib45","first-page":"632","volume":"61","author":"Campbell-Thompson","year":"2001","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M403140200_bib46","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/jnci\/95.11.825","volume":"95","author":"Schernhammer","year":"2003","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1074\/jbc.M403140200_bib47","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/BF00254251","volume":"11","author":"Wei","year":"1983","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1074\/jbc.M403140200_bib48","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0304-3835(95)03970-8","volume":"97","author":"Frankfurt","year":"1995","journal-title":"Cancer Lett."},{"key":"10.1074\/jbc.M403140200_bib49","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0960-0760(00)00047-9","volume":"73","author":"Newton","year":"2000","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1074\/jbc.M403140200_bib50","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/S0959-8049(99)00159-8","volume":"12","author":"Lissoni","year":"1999","journal-title":"Eur. J. Cancer."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582072870X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582072870X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M403140200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T20:01:51Z","timestamp":1705176111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582072870X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":50,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S002192582072870X"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m403140200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}