{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T10:35:36Z","timestamp":1773484536924,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"37","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"vor","delay-in-days":5890,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1074\/jbc.m405308200","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T20:20:22Z","timestamp":1088022022000},"page":"38260-38266","source":"Crossref","is-referenced-by-count":23,"title":["Resistance of Entamoeba histolytica to the Cysteine Proteinase Inhibitor E64 Is Associated with Secretion of Pro-enzymes and Reduced Pathogenicity"],"prefix":"10.1016","volume":"279","author":[{"given":"Nicolas","family":"Nowak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannelore","family":"Lotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egbert","family":"Tannich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Bruchhaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M405308200_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0014-4894(89)90016-7","volume":"68","author":"McKerrow","year":"1989","journal-title":"Exp. Parasitol."},{"key":"10.1074\/jbc.M405308200_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(01)00438-8","volume":"120","author":"Sajid","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M405308200_bib3","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.2174\/1568026023392995","volume":"2","author":"Cazzulo","year":"2002","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1074\/jbc.M405308200_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/1389450003349290","volume":"1","author":"Caffrey","year":"2000","journal-title":"Curr. Drug Targets"},{"key":"10.1074\/jbc.M405308200_bib5","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0020-7519(99)00044-2","volume":"29","author":"McKerrow","year":"1999","journal-title":"Int. J. Parasitol."},{"key":"10.1074\/jbc.M405308200_bib6","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1550-7408.1992.tb04856.x","volume":"39","author":"Bailly","year":"1992","journal-title":"J. Protozool."},{"key":"10.1074\/jbc.M405308200_bib7","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1172\/JCI116262","volume":"91","author":"Rosenthal","year":"1993","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M405308200_bib8","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1172\/JCI113766","volume":"82","author":"Rosenthal","year":"1988","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M405308200_bib9","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1128\/AAC.40.7.1600","volume":"40","author":"Rosenthal","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M405308200_bib10","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1172\/JCI115456","volume":"88","author":"Rosenthal","year":"1991","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M405308200_bib11","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0968-0896(99)00004-8","volume":"7","author":"Olson","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1074\/jbc.M405308200_bib12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/expr.1998.4386","volume":"91","author":"Troeberg","year":"1999","journal-title":"Exp. Parasitol."},{"key":"10.1074\/jbc.M405308200_bib13","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0006-291X(90)92179-4","volume":"170","author":"Ashall","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M405308200_bib14","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1242\/jcs.111.5.597","volume":"111","author":"Engel","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M405308200_bib15","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1432-1033.1992.tb16646.x","volume":"204","author":"Mbawa","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M405308200_bib16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0166-6851(93)90086-D","volume":"58","author":"Harth","year":"1993","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M405308200_bib17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0166-6851(92)90050-T","volume":"52","author":"Meirelles","year":"1992","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M405308200_bib18","doi-asserted-by":"crossref","first-page":"11015","DOI":"10.1073\/pnas.96.20.11015","volume":"96","author":"Selzer","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M405308200_bib19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/expr.1998.4381","volume":"91","author":"Scory","year":"1999","journal-title":"Exp. Parasitol."},{"key":"10.1074\/jbc.M405308200_bib20","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1128\/EC.2.3.501-509.2003","volume":"2","author":"Bruchhaus","year":"2003","journal-title":"Eukaryot. Cell"},{"key":"10.1074\/jbc.M405308200_bib21","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1128\/iai.63.4.1587-1590.1995","volume":"63","author":"Stanley","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M405308200_bib22","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1128\/iai.63.10.4150-4153.1995","volume":"63","author":"Li","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M405308200_bib23","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1046\/j.1365-2958.1998.00837.x","volume":"28","author":"Ankri","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M405308200_bib24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1128\/IAI.67.1.421-422.1999","volume":"67","author":"Ankri","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M405308200_bib25","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1046\/j.1365-2958.2000.02037.x","volume":"37","author":"Zhang","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M405308200_bib26","doi-asserted-by":"crossref","first-page":"26051","DOI":"10.1074\/jbc.274.37.26051","volume":"274","author":"Wassmann","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M405308200_bib27","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/jac\/40.6.833","volume":"40","author":"Samarawickrema","year":"1997","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1074\/jbc.M405308200_bib28","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1128\/JCM.41.10.4745-4750.2003","volume":"41","author":"Blessmann","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1074\/jbc.M405308200_bib29","first-page":"669","volume":"72","author":"Gathiram","year":"1987","journal-title":"S. Afr. Med. J."},{"key":"10.1074\/jbc.M405308200_bib30","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1056\/NEJM200210243471722","volume":"347","author":"Blessmann","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M405308200_bib31","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0035-9203(78)90144-X","volume":"72","author":"Diamond","year":"1978","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1074\/jbc.M405308200_bib32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1046\/j.1365-2958.1998.00662.x","volume":"27","author":"Jacobs","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M405308200_bib33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0166-6851(99)00194-2","volume":"105","author":"Hellberg","year":"2000","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M405308200_bib34","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1017\/S0031182000077040","volume":"111","author":"Leippe","year":"1995","journal-title":"Parasitology"},{"key":"10.1074\/jbc.M405308200_bib35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1084\/jem.160.2.353","volume":"160","author":"Bracha","year":"1984","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M405308200_bib36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1365-2818.1994.tb04785.x","volume":"175","author":"Hohenberg","year":"1994","journal-title":"J. Microsc."},{"key":"10.1074\/jbc.M405308200_bib37","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/pmic.200300462","volume":"3","author":"Bente","year":"2003","journal-title":"Proteomics"},{"key":"10.1074\/jbc.M405308200_bib38","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1084\/jem.185.10.1793","volume":"185","author":"Lotter","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M405308200_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1462-5822.2001.00086.x","volume":"3","author":"Hellberg","year":"2001","journal-title":"Cell Microbiol."},{"key":"10.1074\/jbc.M405308200_bib40","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0076-6879(81)80043-2","volume":"80","author":"Barrett","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M405308200_bib41","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/S0021-9258(19)69895-9","volume":"256","author":"Green","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M405308200_bib42","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1042\/bj2500903","volume":"250","author":"Luaces","year":"1988","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M405308200_bib43","first-page":"115","volume":"47","author":"Scholze","year":"1988","journal-title":"Biomed. Biochim. Acta"},{"key":"10.1074\/jbc.M405308200_bib44","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1042\/bj2850495","volume":"285","author":"Wilcox","year":"1992","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M405308200_bib45","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1146\/annurev.mi.49.100195.002235","volume":"49","author":"Borst","year":"1995","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.M405308200_bib46","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1445-5994.1995.tb02889.x","volume":"25","author":"Cowman","year":"1995","journal-title":"Aust. N. Z. J. Med."},{"key":"10.1074\/jbc.M405308200_bib47","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0169-4758(99)01414-3","volume":"15","author":"Barrett","year":"1999","journal-title":"Parasitol. Today"},{"key":"10.1074\/jbc.M405308200_bib48","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2174\/1389450023347588","volume":"3","author":"Perez-Victoria","year":"2002","journal-title":"Curr. Drug Targets"},{"key":"10.1074\/jbc.M405308200_bib49","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1242\/jcs.113.8.1345","volume":"113","author":"Engel","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M405308200_bib50","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1365-2958.1996.00111.x","volume":"22","author":"Bruchhaus","year":"1996","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M405308200_bib51","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1128\/IAI.67.11.5925-5929.1999","volume":"67","author":"Willhoeft","year":"1999","journal-title":"Infect. Immun."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820728668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820728668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M405308200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T09:20:09Z","timestamp":1641374409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820728668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":51,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0021925820728668"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m405308200","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1001433.232509","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}