{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:24:00Z","timestamp":1790522640455,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"36","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":5866,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1074\/jbc.m405765200","type":"journal-article","created":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T00:13:03Z","timestamp":1087431183000},"page":"37734-37740","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Structure-Activity Relationships of Hainantoxin-IV and Structure Determination of Active and Inactive Sodium Channel Blockers"],"prefix":"10.1016","volume":"279","author":[{"given":"Dongling","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanyun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meichi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocheng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M405765200_bib1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1113\/jphysiol.1952.sp004764","volume":"117","author":"Hodgkin","year":"1952","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M405765200_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)81133-2","volume":"26","author":"Catterall","year":"2000","journal-title":"Neuron"},{"key":"10.1074\/jbc.M405765200_bib3","author":"Yu","year":"2003","journal-title":"Genome Biol."},{"key":"10.1074\/jbc.M405765200_bib4","doi-asserted-by":"crossref","first-page":"7577","DOI":"10.1523\/JNEUROSCI.23-20-07577.2003","volume":"23","author":"Yu","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M405765200_bib5","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0300-9084(00)01174-3","volume":"82","author":"Cest\u00e8le","year":"2000","journal-title":"Biochimie (Paris)"},{"key":"10.1074\/jbc.M405765200_bib6","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0300-9084(00)01166-4","volume":"82","author":"Escoubas","year":"2000","journal-title":"Biochimie (Paris)"},{"key":"10.1074\/jbc.M405765200_bib7","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1007\/s00018-003-2354-x","volume":"60","author":"Liu","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1074\/jbc.M405765200_bib8","doi-asserted-by":"crossref","first-page":"47564","DOI":"10.1074\/jbc.M204063200","volume":"277","author":"Peng","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M405765200_bib9","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0041-0101(02)00280-5","volume":"41","author":"Xiao","year":"2003","journal-title":"Toxicon"},{"key":"10.1074\/jbc.M405765200_bib10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/scientificamerican0867-60","volume":"217","author":"Fuhrman","year":"1967","journal-title":"Sci. Am."},{"key":"10.1074\/jbc.M405765200_bib11","first-page":"516","volume":"34","author":"Liu","year":"2002","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1074\/jbc.M405765200_bib12","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0014-5793(03)01303-6","volume":"555","author":"Li","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M405765200_bib13","series-title":"NMR of Protein and Nucleic Acids","author":"W\u00fcthrich","year":"1986"},{"key":"10.1074\/jbc.M405765200_bib14","series-title":"X-PLOR Manual","author":"Br\u00fcnger","year":"1992"},{"key":"10.1074\/jbc.M405765200_bib15","doi-asserted-by":"crossref","first-page":"11488","DOI":"10.1021\/bi026136m","volume":"41","author":"Zhu","year":"2002","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M405765200_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1469-7793.1997.067bo.x","volume":"501","author":"Hu","year":"1997","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M405765200_bib17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF00228148","volume":"8","author":"Laskowski","year":"1996","journal-title":"J. Biomol. NMR"},{"key":"10.1074\/jbc.M405765200_bib18","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1021\/bi00121a010","volume":"31","author":"Wishart","year":"1992","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M405765200_bib19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0065-3233(08)60520-3","volume":"34","author":"Richardson","year":"1981","journal-title":"Adv. Protein Chem."},{"key":"10.1074\/jbc.M405765200_bib20","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1002\/pro.5560031022","volume":"3","author":"Pallaghy","year":"1994","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M405765200_bib21","first-page":"441","volume":"83","author":"Szil\u00e1gyi","year":"1989","journal-title":"J. Magn. Reson."},{"key":"10.1074\/jbc.M405765200_bib22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0022-2836(91)90214-Q","volume":"222","author":"Wishart","year":"1991","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M405765200_bib23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1749-6632.1986.tb15557.x","volume":"479","author":"Schantz","year":"1986","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1074\/jbc.M405765200_bib24","doi-asserted-by":"crossref","first-page":"16989","DOI":"10.1016\/S0021-9258(19)47329-8","volume":"266","author":"Sato","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M405765200_bib25","doi-asserted-by":"crossref","first-page":"12577","DOI":"10.1021\/bi00165a006","volume":"31","author":"Wakamatsu","year":"1992","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M405765200_bib26","doi-asserted-by":"crossref","first-page":"8229","DOI":"10.1021\/bi00150a016","volume":"31","author":"Becker","year":"1992","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M405765200_bib27","doi-asserted-by":"crossref","first-page":"6908","DOI":"10.1021\/bi00242a014","volume":"30","author":"Lancelin","year":"1991","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M405765200_bib28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0014-5793(01)02714-4","volume":"503","author":"Nakamura","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M405765200_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0014-5793(01)03316-6","volume":"511","author":"Li","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M405765200_bib30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1085\/jgp.119.1.45","volume":"119","author":"Hui","year":"2002","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.M405765200_bib31","doi-asserted-by":"crossref","first-page":"27551","DOI":"10.1074\/jbc.M909719199","volume":"275","author":"Li","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M405765200_bib32","doi-asserted-by":"crossref","first-page":"11072","DOI":"10.1074\/jbc.M010862200","volume":"276","author":"Li","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M405765200_bib33","doi-asserted-by":"crossref","first-page":"9280","DOI":"10.1016\/S0021-9258(17)39364-X","volume":"260","author":"Cruz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M405765200_bib34","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1523\/JNEUROSCI.07-05-01498.1987","volume":"7","author":"Yanagawa","year":"1987","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M405765200_bib35","doi-asserted-by":"crossref","first-page":"6256","DOI":"10.1021\/bi00417a009","volume":"27","author":"Yanagawa","year":"1988","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M405765200_bib36","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1073\/pnas.83.14.5321","volume":"83","author":"Moczydlowski","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M405765200_bib37","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/S0006-3495(97)78218-3","volume":"73","author":"Li","year":"1997","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.M405765200_bib38","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1523\/JNEUROSCI.18-12-04473.1998","volume":"18","author":"Shon","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M405765200_bib39","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1523\/JNEUROSCI.20-01-00076.2000","volume":"20","author":"Safo","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M405765200_bib40","doi-asserted-by":"crossref","first-page":"8824","DOI":"10.1021\/bi960073o","volume":"35","author":"Hill","year":"1996","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M405765200_bib41","doi-asserted-by":"crossref","first-page":"27247","DOI":"10.1074\/jbc.M201611200","volume":"277","author":"Nielsen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M405765200_bib42","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0969-2126(97)00212-8","volume":"15","author":"Hill","year":"1997","journal-title":"Structure"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820730450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820730450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M405765200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T23:58:02Z","timestamp":1688601482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820730450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":42,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0021925820730450"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m405765200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure-Activity Relationships of Hainantoxin-IV and Structure Determination of Active and Inactive Sodium Channel Blockers","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M405765200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2004 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}