{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:54:06Z","timestamp":1791150846073,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"39","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":5864,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1074\/jbc.m408068200","type":"journal-article","created":{"date-parts":[[2004,7,22]],"date-time":"2004-07-22T02:26:02Z","timestamp":1090463162000},"page":"40328-40336","source":"Crossref","is-referenced-by-count":96,"title":["Inhibition of Mitochondrial Na+-Ca2+ Exchange Restores Agonist-induced ATP Production and Ca2+ Handling in Human Complex I Deficiency"],"prefix":"10.1016","volume":"279","author":[{"given":"Henk-Jan","family":"Visch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy A.","family":"Rutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner J.H.","family":"Koopman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan B.","family":"Koenderink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd","family":"Verkaart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theun","family":"de Groot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniko","family":"Varadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lambert P.","family":"van den Heuvel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan A.M.","family":"Smeitink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.G.M.","family":"Willems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M408068200_bib1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/1531-8249(20010201)49:2<195::AID-ANA39>3.0.CO;2-M","volume":"49","author":"Loeffen","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M408068200_bib2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/bbrc.2000.3257","volume":"275","author":"Budde","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M408068200_bib3","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1086\/301716","volume":"62","author":"Van den Heuvel","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1074\/jbc.M408068200_bib4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/1531-8249(199906)45:6<787::AID-ANA13>3.0.CO;2-6","volume":"45","author":"Triepels","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M408068200_bib5","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1086\/302154","volume":"63","author":"Loeffen","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1074\/jbc.M408068200_bib6","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/6772","volume":"21","author":"Schuelke","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M408068200_bib7","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/35072063","volume":"2","author":"Smeitink","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"10.1074\/jbc.M408068200_bib8","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1203\/00006450-199011000-00027","volume":"28","author":"Robinson","year":"1990","journal-title":"Pediatr. Res."},{"key":"10.1074\/jbc.M408068200_bib9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1172\/JCI118798","volume":"98","author":"Pitk\u00e4nen","year":"1996","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M408068200_bib10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1073\/pnas.92.3.729","volume":"92","author":"Moudy","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M408068200_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF01799347","volume":"19","author":"Vazquez-Memije","year":"1996","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1074\/jbc.M408068200_bib12","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/11396","volume":"5","author":"Brini","year":"1999","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M408068200_bib13","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1212\/WNL.56.5.687","volume":"56","author":"Carrozzo","year":"2001","journal-title":"Neurology"},{"key":"10.1074\/jbc.M408068200_bib14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1055\/s-2003-38618","volume":"34","author":"Van der Westhuizen","year":"2003","journal-title":"Neuropediatrics"},{"key":"10.1074\/jbc.M408068200_bib15","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0005-2728(00)00160-2","volume":"1459","author":"Ahlers","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M408068200_bib16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/jmbi.1993.1488","volume":"233","author":"Weidner","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M408068200_bib17","doi-asserted-by":"crossref","first-page":"23577","DOI":"10.1074\/jbc.M002074200","volume":"275","author":"Ahlers","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M408068200_bib18","doi-asserted-by":"crossref","first-page":"13672","DOI":"10.1074\/jbc.M211256200","volume":"278","author":"Koopman","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M408068200_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/bj3530175","volume":"353","author":"Ainscow","year":"2001","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M408068200_bib20","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.2337\/diabetes.51.2007.S162","volume":"51","author":"Ainscow","year":"2002","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M408068200_bib21","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.1002\/j.1460-2075.1995.tb00233.x","volume":"14","author":"Montero","year":"1995","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M408068200_bib22","doi-asserted-by":"crossref","first-page":"22385","DOI":"10.1016\/S0021-9258(18)41540-2","volume":"268","author":"Rutter","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M408068200_bib23","doi-asserted-by":"crossref","first-page":"9896","DOI":"10.1074\/jbc.270.17.9896","volume":"270","author":"Brini","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M408068200_bib24","doi-asserted-by":"crossref","first-page":"12438","DOI":"10.1016\/S0021-9258(18)99893-5","volume":"269","author":"van de Put","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M408068200_bib25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0143416002001860","volume":"32","author":"Alvarez","year":"2002","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M408068200_bib26","doi-asserted-by":"crossref","first-page":"8799","DOI":"10.1016\/S0021-9258(19)84451-4","volume":"261","author":"Assimacopolous-Jeannet","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M408068200_bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/358325a0","volume":"358","author":"Rizzuto","year":"1992","journal-title":"Nature"},{"key":"10.1074\/jbc.M408068200_bib28","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1126\/science.8235595","volume":"262","author":"Rizzuto","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M408068200_bib29","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/BF00762732","volume":"26","author":"Gunter","year":"1994","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1074\/jbc.M408068200_bib30","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1152\/physrev.1999.79.4.1127","volume":"79","author":"Bernardi","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M408068200_bib31","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nature02246","volume":"427","author":"Kirichok","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M408068200_bib32","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1073\/pnas.88.9.3671","volume":"88","author":"Smiley","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M408068200_bib33","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.ph.52.030190.002315","volume":"52","author":"Denton","year":"1990","journal-title":"Annu. Rev. Physiol."},{"key":"10.1074\/jbc.M408068200_bib34","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/0020-711X(90)90105-C","volume":"22","author":"Rutter","year":"1990","journal-title":"Int. J. Biochem."},{"key":"10.1074\/jbc.M408068200_bib35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0092-8674(95)90430-1","volume":"85","author":"Hajn\u00f3czky","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M408068200_bib36","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1093\/emboj\/17.17.4987","volume":"17","author":"Robb-Gaspers","year":"1998","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M408068200_bib37","doi-asserted-by":"crossref","first-page":"13807","DOI":"10.1073\/pnas.96.24.13807","volume":"96","author":"Jouaville","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M408068200_bib38","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0021-9258(18)54024-2","volume":"268","author":"Cox","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M408068200_bib39","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrm1150","volume":"4","author":"Orrenius","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M408068200_bib40","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0006-291X(03)00616-8","volume":"304","author":"Hajnoczky","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M408068200_bib41","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1083\/jcb.200105057","volume":"155","author":"Madesh","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M408068200_bib42","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1054\/ceca.1999.0021","volume":"25","author":"Patel","year":"1999","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M408068200_bib43","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1083\/jcb.126.5.1183","volume":"126","author":"Rizzuto","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M408068200_bib44","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1083\/jcb.200205091","volume":"159","author":"Rapizzi","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M408068200_bib45","doi-asserted-by":"crossref","first-page":"15153","DOI":"10.1074\/jbc.M300180200","volume":"278","author":"Szabadkai","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M408068200_bib46","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/351751a0","volume":"351","author":"Bezprozvanny","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.M408068200_bib47","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/emboj\/18.1.96","volume":"18","author":"Csordas","year":"1999","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M408068200_bib48","doi-asserted-by":"crossref","first-page":"C1263","DOI":"10.1152\/ajpcell.00097.2003","volume":"285","author":"Koopman","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1074\/jbc.M408068200_bib49","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1126\/science.273.5274.503","volume":"273","author":"Khan","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.M408068200_bib50","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0143-4160(98)90116-6","volume":"23","author":"Nicotera","year":"1998","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M408068200_bib51","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1126\/science.284.5412.339","volume":"284","author":"Wang","year":"1999","journal-title":"Science"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820771140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820771140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M408068200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T17:14:08Z","timestamp":1641402848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820771140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":51,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0021925820771140"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m408068200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}