{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:31:48Z","timestamp":1787005908302,"version":"build-2736575974"},"reference-count":69,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T00:00:00Z","timestamp":1604707200000},"content-version":"vor","delay-in-days":5758,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1074\/jbc.m409212200","type":"journal-article","created":{"date-parts":[[2004,12,6]],"date-time":"2004-12-06T20:14:31Z","timestamp":1102364071000},"page":"7194-7205","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Functional Interaction of Protein Kinase C\u03b1 with the Tyrosine Kinases Syk and Src in Human Platelets"],"prefix":"10.1016","volume":"280","author":[{"given":"Giordano","family":"Pula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Crosby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair W.","family":"Poole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M409212200_bib1","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1021\/cr0002801","volume":"101","author":"Newton","year":"2001","journal-title":"Chem. Rev."},{"key":"10.1074\/jbc.M409212200_bib2","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0021-9258(19)75739-1","volume":"262","author":"Shattil","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1042\/bj2890277","volume":"289","author":"Walker","year":"1993","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M409212200_bib4","doi-asserted-by":"crossref","first-page":"15771","DOI":"10.1016\/S0021-9258(18)98476-0","volume":"266","author":"Toullec","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib5","doi-asserted-by":"crossref","first-page":"18424","DOI":"10.1016\/S0021-9258(19)36980-7","volume":"267","author":"Shattil","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib6","doi-asserted-by":"crossref","first-page":"9958","DOI":"10.1074\/jbc.M108965200","volume":"277","author":"Crosby","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib7","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1074\/jbc.M306960200","volume":"279","author":"Murugappan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib8","doi-asserted-by":"crossref","first-page":"10011","DOI":"10.1016\/S0021-9258(19)50192-2","volume":"267","author":"Grabarek","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib9","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/0006-291X(91)90973-B","volume":"178","author":"Crabos","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M409212200_bib10","doi-asserted-by":"crossref","first-page":"15585","DOI":"10.1016\/S0021-9258(19)49576-8","volume":"267","author":"Baldassare","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib11","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/bbrc.1993.1208","volume":"191","author":"Wang","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M409212200_bib12","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1016\/S0021-9258(18)53502-X","volume":"268","author":"Khan","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib13","doi-asserted-by":"crossref","first-page":"39379","DOI":"10.1074\/jbc.M102933200","volume":"276","author":"Yoshioka","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib14","doi-asserted-by":"crossref","first-page":"26374","DOI":"10.1074\/jbc.M212407200","volume":"278","author":"Tabuchi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib15","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/oxfordjournals.jbchem.a003271","volume":"132","author":"Shirai","year":"2002","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1074\/jbc.M409212200_bib16","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1073\/pnas.111158798","volume":"98","author":"Konishi","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M409212200_bib17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0014-5793(94)00514-1","volume":"347","author":"Gschwendt","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M409212200_bib18","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1046\/j.1432-1327.1999.00120.x","volume":"259","author":"Gschwendt","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M409212200_bib19","doi-asserted-by":"crossref","first-page":"5325","DOI":"10.1074\/jbc.271.10.5325","volume":"271","author":"Denning","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib20","doi-asserted-by":"crossref","first-page":"26079","DOI":"10.1016\/S0021-9258(19)74282-3","volume":"268","author":"Denning","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib21","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/S0021-9258(17)41948-X","volume":"269","author":"Li","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib22","first-page":"6727","volume":"14","author":"Li","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M409212200_bib23","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1006\/bbrc.1995.2370","volume":"214","author":"Szallasi","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M409212200_bib24","doi-asserted-by":"crossref","first-page":"13490","DOI":"10.1074\/jbc.270.22.13490","volume":"270","author":"Soltoff","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib25","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1038\/sj.onc.1201684","volume":"16","author":"Shanmugam","year":"1998","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M409212200_bib26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0167-4889(02)00346-4","volume":"1593","author":"Tapia","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M409212200_bib27","doi-asserted-by":"crossref","first-page":"30713","DOI":"10.1074\/jbc.273.46.30713","volume":"273","author":"Brodie","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib28","doi-asserted-by":"crossref","first-page":"35491","DOI":"10.1074\/jbc.M005991200","volume":"275","author":"Kronfeld","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib29","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1006\/bbrc.2001.4657","volume":"282","author":"Wrenn","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M409212200_bib30","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1128\/MCB.22.1.182-195.2002","volume":"22","author":"Blass","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M409212200_bib31","doi-asserted-by":"crossref","first-page":"24533","DOI":"10.1074\/jbc.M301847200","volume":"278","author":"Crosby","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib32","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1006\/bbrc.1994.1630","volume":"200","author":"Liu","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M409212200_bib33","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1006\/bbrc.1995.1430","volume":"208","author":"Wrenn","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M409212200_bib34","doi-asserted-by":"crossref","first-page":"11233","DOI":"10.1073\/pnas.94.21.11233","volume":"94","author":"Konishi","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M409212200_bib35","first-page":"1367","volume":"6","author":"Zang","year":"1995","journal-title":"Cell Growth & Differ."},{"key":"10.1074\/jbc.M409212200_bib36","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1093\/emboj\/16.9.2333","volume":"16","author":"Poole","year":"1997","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M409212200_bib37","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1182\/blood.V94.5.1648","volume":"94","author":"Falati","year":"1999","journal-title":"Blood"},{"key":"10.1074\/jbc.M409212200_bib38","first-page":"95","volume":"272","author":"Crosby","year":"2004","journal-title":"Methods Mol. Biol."},{"key":"10.1074\/jbc.M409212200_bib39","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1182\/blood.V97.4.929","volume":"97","author":"Dormann","year":"2001","journal-title":"Blood"},{"key":"10.1074\/jbc.M409212200_bib40","first-page":"5249","volume":"14","author":"Couture","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M409212200_bib41","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1073\/pnas.85.12.4232","volume":"85","author":"Cooper","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M409212200_bib42","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1083\/jcb.200112113","volume":"157","author":"Obergfell","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M409212200_bib43","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/305317a0","volume":"305","author":"Rink","year":"1983","journal-title":"Nature"},{"key":"10.1074\/jbc.M409212200_bib44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0006-291X(87)80471-0","volume":"144","author":"Yamada","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M409212200_bib45","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1182\/blood.V74.7.2405.2405","volume":"74","author":"Gerrard","year":"1989","journal-title":"Blood"},{"key":"10.1074\/jbc.M409212200_bib46","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1042\/bj2490345","volume":"249","author":"Watson","year":"1988","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M409212200_bib47","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1182\/blood.V97.12.3989","volume":"97","author":"Asazuma","year":"2001","journal-title":"Blood"},{"key":"10.1074\/jbc.M409212200_bib48","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/09537100410001701010","volume":"15","author":"Baker","year":"2004","journal-title":"Platelets"},{"key":"10.1074\/jbc.M409212200_bib49","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1182\/blood-2003-07-2299","volume":"103","author":"Sun","year":"2004","journal-title":"Blood"},{"key":"10.1074\/jbc.M409212200_bib50","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1055\/s-0037-1615855","volume":"82","author":"Watson","year":"1999","journal-title":"Thromb. Haemostasis"},{"key":"10.1074\/jbc.M409212200_bib51","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.1182\/blood.V97.12.3836","volume":"97","author":"Wu","year":"2001","journal-title":"Blood"},{"key":"10.1074\/jbc.M409212200_bib52","doi-asserted-by":"crossref","first-page":"7423","DOI":"10.1073\/pnas.120175097","volume":"97","author":"Kawakami","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M409212200_bib53","doi-asserted-by":"crossref","first-page":"9470","DOI":"10.1073\/pnas.1633695100","volume":"100","author":"Kawakami","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M409212200_bib54","doi-asserted-by":"crossref","first-page":"26668","DOI":"10.1074\/jbc.271.43.26668","volume":"271","author":"Keely","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib55","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1182\/blood.V93.8.2645","volume":"93","author":"Law","year":"1999","journal-title":"Blood"},{"key":"10.1074\/jbc.M409212200_bib56","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.tips.2004.08.006","volume":"25","author":"Poole","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1074\/jbc.M409212200_bib57","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/(SICI)1521-1878(200003)22:3<245::AID-BIES6>3.0.CO;2-X","volume":"22","author":"Jaken","year":"2000","journal-title":"BioEssays"},{"key":"10.1074\/jbc.M409212200_bib58","doi-asserted-by":"crossref","first-page":"40475","DOI":"10.1074\/jbc.M402970200","volume":"279","author":"Jones","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib59","first-page":"2027","volume":"10","author":"Landgren","year":"1995","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M409212200_bib60","first-page":"645","volume":"40","author":"Liebenhoff","year":"1994","journal-title":"Cell. Mol. Biol. (Noisyle-grand)"},{"key":"10.1074\/jbc.M409212200_bib61","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1038\/sj.onc.1201886","volume":"16","author":"Song","year":"1998","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M409212200_bib62","doi-asserted-by":"crossref","first-page":"11360","DOI":"10.1021\/bi000902c","volume":"39","author":"Johnson","year":"2000","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M409212200_bib63","doi-asserted-by":"crossref","first-page":"13216","DOI":"10.1021\/bi010761u","volume":"40","author":"Nalefski","year":"2001","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M409212200_bib64","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/0024-3205(90)90520-2","volume":"47","author":"Wang","year":"1990","journal-title":"Life Sci."},{"key":"10.1074\/jbc.M409212200_bib65","first-page":"1501","volume":"24","author":"Ballen","year":"1996","journal-title":"Exp. Hematol."},{"key":"10.1074\/jbc.M409212200_bib66","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1432-1033.1994.00329.x","volume":"224","author":"Yanagi","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M409212200_bib67","doi-asserted-by":"crossref","first-page":"18797","DOI":"10.1016\/S0021-9258(18)55133-4","volume":"266","author":"Dhar","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M409212200_bib68","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1083\/jcb.200402064","volume":"165","author":"de Virgilio","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M409212200_bib69","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0304-4157(98)00003-3","volume":"1376","author":"Newton","year":"1998","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819628383?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819628383?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M409212200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T12:55:44Z","timestamp":1681217744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819628383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":69,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0021925819628383"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m409212200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional Interaction of Protein Kinase C\u03b1 with the Tyrosine Kinases Syk and Src in Human Platelets","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M409212200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2005 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}