{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:04:57Z","timestamp":1791173097052,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"25","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":5600,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1074\/jbc.m500716200","type":"journal-article","created":{"date-parts":[[2005,4,22]],"date-time":"2005-04-22T00:13:00Z","timestamp":1114128780000},"page":"24212-24220","source":"Crossref","is-referenced-by-count":55,"title":["G Protein-coupled Receptor Activation Rapidly Stimulates Focal Adhesion Kinase Phosphorylation at Ser-843"],"prefix":"10.1016","volume":"280","author":[{"given":"Robert S.","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo O.","family":"J\u00e1camo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Sinnett-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Rozengurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M500716200_bib1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/0092-8674(92)90385-P","volume":"71","author":"Zachary","year":"1992","journal-title":"Cell"},{"key":"10.1074\/jbc.M500716200_bib2","first-page":"81","volume":"24","author":"Rozengurt","year":"1995","journal-title":"Cancer Surv."},{"key":"10.1074\/jbc.M500716200_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/bies.950190208","volume":"19","author":"Hanks","year":"1997","journal-title":"BioEssays"},{"key":"10.1074\/jbc.M500716200_bib4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0079-6107(98)00052-2","volume":"71","author":"Schlaepfer","year":"1999","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1074\/jbc.M500716200_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4889(01)00123-9","volume":"1540","author":"Schaller","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M500716200_bib6","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1242\/jcs.00373","volume":"116","author":"Parsons","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M500716200_bib7","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1128\/MCB.15.5.2819","volume":"15","author":"Eide","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M500716200_bib8","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1128\/MCB.15.2.954","volume":"15","author":"Calalb","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M500716200_bib9","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1128\/MCB.19.7.4806","volume":"19","author":"Owen","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M500716200_bib10","doi-asserted-by":"crossref","first-page":"17788","DOI":"10.1074\/jbc.M100984200","volume":"276","author":"Salazar","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M500716200_bib11","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/377539a0","volume":"377","author":"Ilic","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M500716200_bib12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/jcs.110.4.401","volume":"110","author":"Ilic","year":"1997","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M500716200_bib13","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1091\/mbc.7.8.1209","volume":"7","author":"Gilmore","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M500716200_bib14","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1242\/jcs.109.7.1787","volume":"109","author":"Cary","year":"1996","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M500716200_bib15","doi-asserted-by":"crossref","first-page":"5933","DOI":"10.1093\/emboj\/17.20.5933","volume":"17","author":"Sieg","year":"1998","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M500716200_bib16","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1242\/jcs.112.16.2677","volume":"112","author":"Sieg","year":"1999","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M500716200_bib17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35010517","volume":"2","author":"Sieg","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M500716200_bib18","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ncb1094","volume":"6","author":"Webb","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M500716200_bib19","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1126\/science.1091325","volume":"303","author":"Palazzo","year":"2004","journal-title":"Science"},{"key":"10.1074\/jbc.M500716200_bib20","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S1097-2765(03)00179-5","volume":"11","author":"Zhao","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M500716200_bib21","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1083\/jcb.135.5.1383","volume":"135","author":"Hungerford","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M500716200_bib22","first-page":"413","volume":"7","author":"Xu","year":"1996","journal-title":"Cell Growth Differ."},{"key":"10.1074\/jbc.M500716200_bib23","doi-asserted-by":"crossref","first-page":"17102","DOI":"10.1074\/jbc.273.27.17102","volume":"273","author":"Gervais","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M500716200_bib24","first-page":"755","volume":"1","author":"Golubovskaya","year":"2003","journal-title":"Mol. Cancer Res."},{"key":"10.1074\/jbc.M500716200_bib25","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF02409059","volume":"3","author":"Owens","year":"1996","journal-title":"Ann. Surg. Oncol."},{"key":"10.1074\/jbc.M500716200_bib26","first-page":"2752","volume":"55","author":"Owens","year":"1995","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M500716200_bib27","first-page":"3175","volume":"22","author":"Mukai","year":"2002","journal-title":"Anticancer Res."},{"key":"10.1074\/jbc.M500716200_bib28","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1023\/A:1023725029589","volume":"22","author":"Gabarra-Niecko","year":"2003","journal-title":"Cancer Metastasis Rev."},{"key":"10.1074\/jbc.M500716200_bib29","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1083\/jcb.200212114","volume":"160","author":"Hsia","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M500716200_bib30","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0002-9440(10)63370-6","volume":"165","author":"Sood","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.M500716200_bib31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbamcr.2004.04.008","volume":"1692","author":"Schlaepfer","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M500716200_bib32","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1083\/jcb.144.2.315","volume":"144","author":"Yamakita","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M500716200_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1091\/mbc.12.1.1","volume":"12","author":"Ma","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M500716200_bib34","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0092-8674(03)00605-6","volume":"114","author":"Xie","year":"2003","journal-title":"Cell"},{"key":"10.1074\/jbc.M500716200_bib35","doi-asserted-by":"crossref","first-page":"22631","DOI":"10.1074\/jbc.M210876200","volume":"278","author":"Hunger-Glaser","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M500716200_bib36","doi-asserted-by":"crossref","first-page":"16883","DOI":"10.1074\/jbc.M313225200","volume":"279","author":"Sinnett-Smith","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M500716200_bib37","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/jcp.20018","volume":"200","author":"Hunger-Glaser","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"10.1074\/jbc.M500716200_bib38","doi-asserted-by":"crossref","first-page":"28371","DOI":"10.1074\/jbc.274.40.28371","volume":"274","author":"Salazar","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M500716200_bib39","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1126\/science.3018928","volume":"234","author":"Rozengurt","year":"1986","journal-title":"Science"},{"key":"10.1074\/jbc.M500716200_bib40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2362.1991.tb01801.x","volume":"21","author":"Rozengurt","year":"1991","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1074\/jbc.M500716200_bib41","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/(SICI)1097-4652(199812)177:4<507::AID-JCP2>3.0.CO;2-K","volume":"177","author":"Rozengurt","year":"1998","journal-title":"J. Cell. Physiol."},{"key":"10.1074\/jbc.M500716200_bib42","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S1043-2760(01)00544-6","volume":"13","author":"Rozengurt","year":"2002","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1074\/jbc.M500716200_bib43","doi-asserted-by":"crossref","first-page":"21471","DOI":"10.1074\/jbc.271.35.21471","volume":"271","author":"Seufferlein","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M500716200_bib44","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1074\/jbc.272.4.2509","volume":"272","author":"Withers","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M500716200_bib45","doi-asserted-by":"crossref","first-page":"23952","DOI":"10.1074\/jbc.272.38.23952","volume":"272","author":"Zugaza","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M500716200_bib46","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1083\/jcb.102.6.2211","volume":"102","author":"Zachary","year":"1986","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M500716200_bib47","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1073\/pnas.84.16.5768","volume":"84","author":"Lopez-Rivas","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M500716200_bib48","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/j.1460-2075.1988.tb03128.x","volume":"7","author":"N\u00e5nberg","year":"1988","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M500716200_bib49","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1021\/bi00552a018","volume":"19","author":"Tsien","year":"1980","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M500716200_bib50","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1073\/pnas.87.7.2466","volume":"87","author":"Thastrup","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M500716200_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(94)00492-7","volume":"347","author":"Means","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M500716200_bib52","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0962-8924(00)01800-6","volume":"10","author":"Chin","year":"2000","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.M500716200_bib53","doi-asserted-by":"crossref","first-page":"17240","DOI":"10.1016\/S0021-9258(18)45515-9","volume":"262","author":"el-Saleh","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M500716200_bib54","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.1073\/pnas.78.7.4354","volume":"78","author":"Hidaka","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M500716200_bib55","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1006\/bbrc.1995.2040","volume":"212","author":"Ishida","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M500716200_bib56","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0896-6273(88)90109-2","volume":"1","author":"Miller","year":"1988","journal-title":"Neuron"},{"key":"10.1074\/jbc.M500716200_bib57","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/01.RES.0000125626.33738.E2","volume":"94","author":"Wehrens","year":"2004","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M500716200_bib58","doi-asserted-by":"crossref","first-page":"14261","DOI":"10.1016\/S0021-9258(19)85236-5","volume":"268","author":"Sinnett-Smith","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M500716200_bib59","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1074\/jbc.R000013200","volume":"276","author":"Soderling","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M500716200_bib60","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.pa.36.040196.002405","volume":"36","author":"Exton","year":"1996","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1074\/jbc.M500716200_bib61","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1092053","volume":"302","author":"Ridley","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M500716200_bib62","doi-asserted-by":"crossref","first-page":"C1527","DOI":"10.1152\/ajpcell.1993.265.6.C1527","volume":"265","author":"Brundage","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M500716200_bib63","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1523\/JNEUROSCI.15-01-00584.1995","volume":"15","author":"Anton","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M500716200_bib64","doi-asserted-by":"crossref","first-page":"8479","DOI":"10.1073\/pnas.0401000101","volume":"101","author":"Kumada","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M500716200_bib65","doi-asserted-by":"crossref","first-page":"28715","DOI":"10.1074\/jbc.M404054200","volume":"279","author":"Giannone","year":"2004","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820674804?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820674804?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M500716200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T15:29:05Z","timestamp":1639841345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820674804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":65,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S0021925820674804"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m500716200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}