{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:24:55Z","timestamp":1772137495975,"version":"3.50.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"31","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":5523,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1074\/jbc.m503640200","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T20:12:44Z","timestamp":1118347964000},"page":"28572-28580","source":"Crossref","is-referenced-by-count":50,"title":["Gene Disruption of Spred-2 Causes Dwarfism"],"prefix":"10.1016","volume":"280","author":[{"given":"Karin","family":"Bundschu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus-Peter","family":"Knobeloch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Ullrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Schinke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Amling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine M.","family":"Engelhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Renn\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Walter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Schuh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M503640200_bib1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature01657","volume":"423","author":"Kronenberg","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M503640200_bib2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1359-6101(96)00039-1","volume":"7","author":"Goldfarb","year":"1996","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1074\/jbc.M503640200_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0065-230X(08)60305-X","volume":"59","author":"Basilico","year":"1992","journal-title":"Adv. Cancer Res."},{"key":"10.1074\/jbc.M503640200_bib4","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1006\/dbio.1993.1040","volume":"155","author":"Peters","year":"1993","journal-title":"Dev. Biol."},{"key":"10.1074\/jbc.M503640200_bib5","doi-asserted-by":"crossref","first-page":"D781","DOI":"10.2741\/A321","volume":"3","author":"Naski","year":"1998","journal-title":"Front. Biosci."},{"key":"10.1074\/jbc.M503640200_bib6","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1101\/gad.965702","volume":"16","author":"Ohbayashi","year":"2002","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M503640200_bib7","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/371252a0","volume":"371","author":"Rousseau","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M503640200_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0092-8674(94)90302-6","volume":"78","author":"Shiang","year":"1994","journal-title":"Cell"},{"key":"10.1074\/jbc.M503640200_bib9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng0795-357","volume":"10","author":"Bellus","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M503640200_bib10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ng0395-321","volume":"9","author":"Tavormina","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M503640200_bib11","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1136\/jmg.16.2.140","volume":"16","author":"Oberklaid","year":"1979","journal-title":"J. Med. Genet."},{"key":"10.1074\/jbc.M503640200_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/hmg\/8.1.35","volume":"8","author":"Li","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M503640200_bib13","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1073\/pnas.96.8.4455","volume":"96","author":"Wang","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M503640200_bib14","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/hmg\/9.11.1603","volume":"9","author":"Iwata","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M503640200_bib15","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/hmg\/10.12.1255","volume":"10","author":"Iwata","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M503640200_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/hmg\/9.2.249","volume":"9","author":"Segev","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M503640200_bib17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/hmg\/10.5.457","volume":"10","author":"Chen","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M503640200_bib18","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ng0496-390","volume":"12","author":"Colvin","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M503640200_bib19","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0092-8674(00)81069-7","volume":"84","author":"Deng","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.M503640200_bib20","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1091\/mbc.6.12.1861","volume":"6","author":"Coffin","year":"1995","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M503640200_bib21","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1359\/jbmr.1999.14.11.1909","volume":"14","author":"Garofalo","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"10.1074\/jbc.M503640200_bib22","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1101\/gad.965602","volume":"16","author":"Liu","year":"2002","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M503640200_bib23","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1101\/gad.13.11.1361","volume":"13","author":"Sahni","year":"1999","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M503640200_bib24","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1042\/bj3420677","volume":"342","author":"Weksler","year":"1999","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M503640200_bib25","doi-asserted-by":"crossref","first-page":"6621","DOI":"10.1074\/jbc.272.10.6621","volume":"272","author":"Kanai","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M503640200_bib26","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/386288a0","volume":"386","author":"Su","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M503640200_bib27","doi-asserted-by":"crossref","first-page":"13007","DOI":"10.1074\/jbc.273.21.13007","volume":"273","author":"Legeai-Mallet","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M503640200_bib28","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1038\/sj.onc.1203650","volume":"19","author":"Hart","year":"2000","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M503640200_bib29","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1074\/jbc.M002959200","volume":"276","author":"Choi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M503640200_bib30","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1073\/pnas.97.3.1113","volume":"97","author":"Murakami","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M503640200_bib31","doi-asserted-by":"crossref","first-page":"15962","DOI":"10.1074\/jbc.M102777200","volume":"277","author":"Kong","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M503640200_bib32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1101\/gad.1179104","volume":"18","author":"Murakami","year":"2004","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M503640200_bib33","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/nm971","volume":"10","author":"Yasoda","year":"2004","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M503640200_bib34","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1359\/jbmr.2003.18.11.2043","volume":"18","author":"Koike","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1074\/jbc.M503640200_bib35","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/35088082","volume":"412","author":"Wakioka","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M503640200_bib36","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1242\/dev.126.20.4465","volume":"126","author":"Minowada","year":"1999","journal-title":"Development"},{"key":"10.1074\/jbc.M503640200_bib37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0092-8674(00)80919-8","volume":"92","author":"Hacohen","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M503640200_bib38","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1074\/jbc.M006922200","volume":"276","author":"Lee","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M503640200_bib39","doi-asserted-by":"crossref","first-page":"36804","DOI":"10.1074\/jbc.C100386200","volume":"276","author":"Sasaki","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M503640200_bib40","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1038\/sj.onc.1207759","volume":"23","author":"Miyoshi","year":"2004","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M503640200_bib41","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0006-291X(03)00259-6","volume":"302","author":"Kato","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M503640200_bib42","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00418-004-0725-6","volume":"122","author":"Engelhardt","year":"2004","journal-title":"Histochem. Cell Biol."},{"issue":"Suppl. 1","key":"10.1074\/jbc.M503640200_bib43","doi-asserted-by":"crossref","first-page":"S303","DOI":"10.1016\/S0925-4773(03)00132-1","volume":"119","author":"Hashimoto","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1074\/jbc.M503640200_bib44","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1084\/jem.20030830","volume":"199","author":"Nobuhisa","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M503640200_bib45","doi-asserted-by":"crossref","first-page":"52543","DOI":"10.1074\/jbc.M405189200","volume":"279","author":"Nonami","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M503640200_bib46","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1084\/jem.20040616","volume":"201","author":"Inoue","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M503640200_bib47","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1210\/endo.140.11.7110","volume":"140","author":"Amling","year":"1999","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M503640200_bib48","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0378-1119(96)00506-9","volume":"183","author":"DeMille","year":"1996","journal-title":"Gene (Amst.)"},{"key":"10.1074\/jbc.M503640200_bib49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0014-5793(01)03291-4","volume":"513","author":"Ball","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M503640200_bib50","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0968-0004(00)01785-0","volume":"26","author":"Reinhard","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M503640200_bib51","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/ncb0503-377","volume":"5","author":"Christofori","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M503640200_bib52","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrm1400","volume":"5","author":"Kim","year":"2004","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1074\/jbc.M503640200_bib53","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0014-5793(98)01541-5","volume":"441","author":"Callebaut","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M503640200_bib54","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1023\/B:JNMR.0000032526.17586.8c","volume":"29","author":"Zimmermann","year":"2004","journal-title":"J. Biomol. NMR"},{"key":"10.1074\/jbc.M503640200_bib55","first-page":"H2471","volume":"285","author":"Eigenthaler","year":"2003","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M503640200_bib56","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/emboj\/18.1.37","volume":"18","author":"Aszodi","year":"1999","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M503640200_bib57","doi-asserted-by":"crossref","first-page":"8120","DOI":"10.1073\/pnas.96.14.8120","volume":"96","author":"Hauser","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M503640200_bib58","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0896-6273(00)81092-2","volume":"22","author":"Lanier","year":"1999","journal-title":"Neuron"},{"key":"10.1074\/jbc.M503640200_bib59","doi-asserted-by":"crossref","first-page":"8029","DOI":"10.1523\/JNEUROSCI.1057-04.2004","volume":"24","author":"Menzies","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M503640200_bib60","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0092-8674(00)81559-7","volume":"100","author":"Vasioukhin","year":"2000","journal-title":"Cell"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820565587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820565587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M503640200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T21:40:00Z","timestamp":1641332400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820565587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":60,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0021925820565587"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m503640200","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1026619.327628","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}