{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:24:53Z","timestamp":1787977493274,"version":"build-2784847793"},"reference-count":40,"publisher":"Elsevier BV","issue":"35","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":5505,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1074\/jbc.m504398200","type":"journal-article","created":{"date-parts":[[2005,7,2]],"date-time":"2005-07-02T05:39:17Z","timestamp":1120282757000},"page":"30949-30955","source":"Crossref","is-referenced-by-count":79,"title":["Multiple Elements Jointly Determine Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases 4 and 7"],"prefix":"10.1016","volume":"280","author":[{"given":"Huanchen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengming","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M504398200_bib1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1006\/frne.1999.0193","volume":"21","author":"Antoni","year":"2000","journal-title":"Front. Neuroendocrinol."},{"key":"10.1074\/jbc.M504398200_bib2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/1097-4652(200009)184:3<409::AID-JCP16>3.0.CO;2-K","volume":"184","author":"Carvajal","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"10.1074\/jbc.M504398200_bib3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1164\/ajrccm.157.2.9708012","volume":"157","author":"Torphy","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1074\/jbc.M504398200_bib4","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0955-0674(99)00073-3","volume":"12","author":"Soderling","year":"2000","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M504398200_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1043-2760(01)00523-9","volume":"13","author":"Mehats","year":"2002","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1074\/jbc.M504398200_bib6","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s003450100221","volume":"19","author":"Truss","year":"2001","journal-title":"World J. Urol."},{"key":"10.1074\/jbc.M504398200_bib7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1527-3466.2001.tb00076.x","volume":"19","author":"Liu","year":"2001","journal-title":"Cardiovas. Drug Rev."},{"key":"10.1074\/jbc.M504398200_bib8","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S1367-5931(00)00224-6","volume":"5","author":"Huang","year":"2001","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1074\/jbc.M504398200_bib9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1742-1241.2002.tb11296.x","volume":"56","author":"Corbin","year":"2002","journal-title":"Int. J. Clin. Pract."},{"key":"10.1074\/jbc.M504398200_bib10","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrd893","volume":"1","author":"Rotella","year":"2002","journal-title":"Nature Rev. Drug Discovery"},{"key":"10.1074\/jbc.M504398200_bib11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/med.20020","volume":"25","author":"Castro","year":"2005","journal-title":"Med. Res. Rev."},{"key":"10.1074\/jbc.M504398200_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0140-6736(05)17708-3","volume":"365","author":"Lipworth","year":"2005","journal-title":"Lancet"},{"key":"10.1074\/jbc.M504398200_bib13","first-page":"48","volume":"57","author":"Giembycz","year":"2002","journal-title":"Monaldi Arch. Chest Dis."},{"key":"10.1074\/jbc.M504398200_bib14","doi-asserted-by":"crossref","first-page":"14188","DOI":"10.1073\/pnas.93.24.14188","volume":"93","author":"Bloom","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M504398200_bib15","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1111\/j.1476-5381.1996.tb15629.x","volume":"118","author":"Giembycz","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1074\/jbc.M504398200_bib16","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.283.5403.848","volume":"283","author":"Li","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.M504398200_bib17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/syn.1043","volume":"40","author":"Miro","year":"2001","journal-title":"Synapse"},{"key":"10.1074\/jbc.M504398200_bib18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0898-6568(01)00250-9","volume":"14","author":"Lee","year":"2002","journal-title":"Cell Signal"},{"key":"10.1074\/jbc.M504398200_bib19","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.4049\/jimmunol.171.12.6414","volume":"171","author":"Yang","year":"2003","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M504398200_bib20","doi-asserted-by":"crossref","first-page":"12925","DOI":"10.1016\/S0021-9258(18)31474-1","volume":"268","author":"Michaeli","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M504398200_bib21","doi-asserted-by":"crossref","first-page":"16152","DOI":"10.1074\/jbc.272.26.16152","volume":"272","author":"Han","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M504398200_bib22","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1006\/bbrc.2000.2743","volume":"272","author":"Gardner","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M504398200_bib23","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1073\/pnas.97.1.472","volume":"97","author":"Hetman","year":"2000","journal-title":"Proc. Natl. Acad. Sci., U. S. A."},{"key":"10.1074\/jbc.M504398200_bib24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/prep.2002.1620","volume":"25","author":"Richter","year":"2002","journal-title":"Protein Expression Purif."},{"key":"10.1074\/jbc.M504398200_bib25","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0969-2126(03)00123-0","volume":"11","author":"Huai","year":"2003","journal-title":"Structure"},{"key":"10.1074\/jbc.M504398200_bib26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M504398200_bib27","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0076-6879(97)76079-8","volume":"276","author":"Navaza","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M504398200_bib28","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","volume":"50","author":"Collaborative Computational Project, Number 4","year":"1994","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M504398200_bib29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","volume":"47","author":"Jones","year":"1991","journal-title":"Acta Crystallogr. Sect. A"},{"key":"10.1074\/jbc.M504398200_bib30","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","volume":"54","author":"Br\u00fcnger","year":"1998","journal-title":"Acta Cryst. Sect. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M504398200_bib31","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1126\/science.288.5472.1822","volume":"288","author":"Xu","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M504398200_bib32","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jmb.2004.01.040","volume":"337","author":"Xu","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M504398200_bib33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0014-5793(02)03396-3","volume":"530","author":"Lee","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M504398200_bib34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nature01914","volume":"425","author":"Sung","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M504398200_bib35","doi-asserted-by":"crossref","first-page":"13220","DOI":"10.1021\/bi034653e","volume":"42","author":"Huai","year":"2003","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M504398200_bib36","doi-asserted-by":"crossref","first-page":"13095","DOI":"10.1074\/jbc.M311556200","volume":"279","author":"Huai","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M504398200_bib37","doi-asserted-by":"crossref","first-page":"9624","DOI":"10.1073\/pnas.0401120101","volume":"101","author":"Huai","year":"2004","journal-title":"Proc. Natl. Acad. Sci., U. S. A."},{"key":"10.1074\/jbc.M504398200_bib38","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.molcel.2004.07.005","volume":"15","author":"Zhang","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M504398200_bib39","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.str.2004.10.004","volume":"12","author":"Card","year":"2004","journal-title":"Structure"},{"key":"10.1074\/jbc.M504398200_bib40","doi-asserted-by":"crossref","first-page":"6091","DOI":"10.1021\/bi049868i","volume":"43","author":"Scapin","year":"2004","journal-title":"Biochemistry"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820793671?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820793671?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M504398200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T17:04:02Z","timestamp":1683133442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820793671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":40,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0021925820793671"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m504398200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}