{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:11:58Z","timestamp":1791277918893,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"37","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:00:00Z","timestamp":1601078400000},"content-version":"vor","delay-in-days":5504,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1074\/jbc.m504553200","type":"journal-article","created":{"date-parts":[[2005,7,20]],"date-time":"2005-07-20T20:12:39Z","timestamp":1121890359000},"page":"32230-32237","source":"Crossref","is-referenced-by-count":72,"title":["TRPC4 Knockdown Suppresses Epidermal Growth Factor-induced Store-operated Channel Activation and Growth in Human Corneal Epithelial Cells"],"prefix":"10.1016","volume":"280","author":[{"given":"Hua","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Mergler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingcai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Bonanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Pleyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Reinach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M504553200_bib1","first-page":"968","volume":"16","author":"Klyce","year":"1977","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1074\/jbc.M504553200_bib2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1177\/153537020222600711","volume":"226","author":"Lu","year":"2001","journal-title":"Exp. Biol. Med."},{"key":"10.1074\/jbc.M504553200_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00232-003-2025-9","volume":"194","author":"Yang","year":"2003","journal-title":"J. Membr. Biol."},{"key":"10.1074\/jbc.M504553200_bib4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0092-8674(93)80061-I","volume":"75","author":"Putney","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M504553200_bib5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0092-8674(95)90408-5","volume":"80","author":"Clapham","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M504553200_bib6","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev.cb.06.110190.003435","volume":"6","author":"Tsien","year":"1990","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1074\/jbc.M504553200_bib7","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1210\/edrv-14-5-610","volume":"14","author":"Putney","year":"1993","journal-title":"Endocr. Rev."},{"key":"10.1074\/jbc.M504553200_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0143-4160(86)90026-6","volume":"7","author":"Putney","year":"1986","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M504553200_bib9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0014-5793(90)80692-C","volume":"263","author":"Irvine","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M504553200_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3120001","volume":"312","author":"Berridge","year":"1995","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M504553200_bib11","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/364809a0","volume":"364","author":"Randriamampita","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.M504553200_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1073\/pnas.96.1.121","volume":"96","author":"Csutora","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M504553200_bib13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0143-4160(03)00043-5","volume":"33","author":"Harteneck","year":"2003","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M504553200_bib14","first-page":"RE1","author":"Montell","year":"2001","journal-title":"Sci. STKE 2001"},{"key":"10.1074\/jbc.M504553200_bib15","first-page":"44","volume":"19","author":"Landsberg","year":"2004","journal-title":"News Physiol. Sci."},{"key":"10.1074\/jbc.M504553200_bib16","doi-asserted-by":"crossref","first-page":"C1192","DOI":"10.1152\/ajpcell.00158.2004","volume":"287","author":"Zhang","year":"2004","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M504553200_bib17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1042\/bj3540285","volume":"354","author":"Gregory","year":"2001","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M504553200_bib18","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1126\/science.287.5458.1647","volume":"287","author":"Ma","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M504553200_bib19","doi-asserted-by":"crossref","first-page":"28562","DOI":"10.1074\/jbc.M003147200","volume":"275","author":"van Rossum","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M504553200_bib20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ceca.2004.09.001","volume":"37","author":"Rychkov","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M504553200_bib21","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1096\/fj.02-0786fje","volume":"17","author":"Harks","year":"2003","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M504553200_bib22","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1523\/JNEUROSCI.0934-04.2004","volume":"24","author":"Chung","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M504553200_bib23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0896-6273(02)00641-4","volume":"34","author":"Delmas","year":"2002","journal-title":"Neuron"},{"key":"10.1074\/jbc.M504553200_bib24","doi-asserted-by":"crossref","first-page":"21617","DOI":"10.1074\/jbc.M202549200","volume":"277","author":"Trebak","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M504553200_bib25","doi-asserted-by":"crossref","first-page":"G604","DOI":"10.1152\/ajpcell.00429.2002","volume":"284","author":"Lee","year":"2003","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M504553200_bib26","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/sj.bjp.0706197","volume":"145","author":"Xu","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1074\/jbc.M504553200_bib27","doi-asserted-by":"crossref","first-page":"47767","DOI":"10.1074\/jbc.C100607200","volume":"276","author":"Voets","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M504553200_bib28","doi-asserted-by":"crossref","first-page":"26950","DOI":"10.1074\/jbc.M203700200","volume":"277","author":"Schindl","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M504553200_bib29","doi-asserted-by":"crossref","first-page":"35741","DOI":"10.1074\/jbc.M404164200","volume":"279","author":"Hu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M504553200_bib30","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.1074\/jbc.M304334200","volume":"279","author":"Li","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M504553200_bib31","doi-asserted-by":"crossref","first-page":"C357","DOI":"10.1152\/ajpcell.00068.2004","volume":"287","author":"Wang","year":"2004","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M504553200_bib32","first-page":"614","volume":"36","author":"Araki-Sasaki","year":"1995","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1074\/jbc.M504553200_bib33","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00232-001-0057-6","volume":"183","author":"Yang","year":"2001","journal-title":"J. Membr. Biol."},{"key":"10.1074\/jbc.M504553200_bib34","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M504553200_bib35","author":"Sun","year":"2004","journal-title":"BMC Physiology"},{"key":"10.1074\/jbc.M504553200_bib36","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0014-4835(03)00150-7","volume":"77","author":"Sun","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1074\/jbc.M504553200_bib37","doi-asserted-by":"crossref","first-page":"37559","DOI":"10.1074\/jbc.M006635200","volume":"275","author":"Tang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M504553200_bib38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0165-0270(94)90031-0","volume":"51","author":"Barry","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"10.1074\/jbc.M504553200_bib39","first-page":"H746","volume":"280","author":"Golovina","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M504553200_bib40","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1469-7793.2000.00071.x","volume":"527","author":"Skryma","year":"2000","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1074\/jbc.M504553200_bib41","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1085\/jgp.107.5.597","volume":"107","author":"Zweifach","year":"1996","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.M504553200_bib42","first-page":"L144","volume":"283","author":"Sweeney","year":"2002","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M504553200_bib43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbamcr.2004.09.001","volume":"1742","author":"Spassova","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M504553200_bib44","first-page":"RE3","author":"Montell","year":"2005","journal-title":"Sci. STKE 2005"},{"key":"10.1074\/jbc.M504553200_bib45","doi-asserted-by":"crossref","first-page":"C316","DOI":"10.1152\/ajpcell.00125.2002","volume":"284","author":"Yu","year":"2003","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M504553200_bib46","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.bcp.2005.01.011","volume":"69","author":"Padar","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M504553200_bib47","first-page":"L870","volume":"280","author":"McDaniel","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M504553200_bib48","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1161\/hh2201.100315","volume":"89","author":"Ng","year":"2001","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M504553200_bib49","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/00005392-200102000-00084","volume":"165","author":"Sui","year":"2001","journal-title":"J. Urol."},{"key":"10.1074\/jbc.M504553200_bib50","doi-asserted-by":"crossref","first-page":"C1078","DOI":"10.1152\/ajpcell.00463.2003","volume":"286","author":"Bradley","year":"2004","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M504553200_bib51","first-page":"H692","volume":"279","author":"Hobai","year":"2000","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M504553200_bib52","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1365-201X.2001.00907.x","volume":"173","author":"Petkov","year":"2001","journal-title":"Acta Physiol. Scand."},{"key":"10.1074\/jbc.M504553200_bib53","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF00232803","volume":"144","author":"Rich","year":"1995","journal-title":"J. Membr. Biol."},{"key":"10.1074\/jbc.M504553200_bib54","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/exer.1999.0783","volume":"70","author":"Islam","year":"2000","journal-title":"Exp. Eye Res."},{"key":"10.1074\/jbc.M504553200_bib55","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1074\/jbc.M406073200","volume":"280","author":"Larsson","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M504553200_bib56","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/0470862580.ch13","volume":"258","author":"Venkatachalam","year":"2004","journal-title":"Novartis Found. Symp."},{"key":"10.1074\/jbc.M504553200_bib57","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1083\/jcb.138.6.1333","volume":"138","author":"Zitt","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M504553200_bib58","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","volume":"391","author":"Hamill","year":"1981","journal-title":"Pfluegers Arch."},{"key":"10.1074\/jbc.M504553200_bib59","first-page":"PE36","author":"Nilius","year":"2004","journal-title":"Sci. STKE 2004"},{"key":"10.1074\/jbc.M504553200_bib60","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1681\/ASN.V12147","volume":"12","author":"Ma","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1074\/jbc.M504553200_bib61","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.exer.2004.09.012","volume":"80","author":"Mergler","year":"2005","journal-title":"Exp. Eye Res."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820791969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820791969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M504553200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T18:54:54Z","timestamp":1706381694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820791969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":61,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0021925820791969"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m504553200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}