{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:01:28Z","timestamp":1790899288835,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"46","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":5449,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1074\/jbc.m505223200","type":"journal-article","created":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T20:12:43Z","timestamp":1122927163000},"page":"38505-38512","source":"Crossref","is-referenced-by-count":58,"title":["Ca2+ Dysregulation Induces Mitochondrial Depolarization and Apoptosis"],"prefix":"10.1016","volume":"280","author":[{"given":"Shigeki","family":"Miyamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Howes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Gerald W.","family":"Dorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Heller","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M505223200_bib1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0092-8674(00)80729-1","volume":"97","author":"Hirota","year":"1999","journal-title":"Cell."},{"key":"10.1074\/jbc.M505223200_bib2","doi-asserted-by":"crossref","first-page":"10140","DOI":"10.1073\/pnas.95.17.10140","volume":"95","author":"Adams","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M505223200_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1471-4914(03)00025-X","volume":"9","author":"Kang","year":"2003","journal-title":"Trends Mol. Med."},{"key":"10.1074\/jbc.M505223200_bib4","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nm719","volume":"8","author":"Yussman","year":"2002","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M505223200_bib5","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1161\/01.CIR.0000101920.72665.58","volume":"108","author":"Hayakawa","year":"2003","journal-title":"Circulation."},{"key":"10.1074\/jbc.M505223200_bib6","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1172\/JCI17664","volume":"111","author":"Wencker","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M505223200_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(03)00278-3","volume":"541","author":"Borutaite","year":"2003","journal-title":"FEBS. Lett."},{"key":"10.1074\/jbc.M505223200_bib8","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1161\/01.CIR.97.15.1488","volume":"97","author":"Sakata","year":"1998","journal-title":"Circulation."},{"key":"10.1074\/jbc.M505223200_bib9","doi-asserted-by":"crossref","first-page":"13893","DOI":"10.1073\/pnas.95.23.13893","volume":"95","author":"Mende","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M505223200_bib10","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1038\/sj.onc.1204275","volume":"20","author":"Adams","year":"2001","journal-title":"Oncogene."},{"key":"10.1074\/jbc.M505223200_bib11","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0002-9149(84)80208-8","volume":"54","author":"Swedberg","year":"1984","journal-title":"Am. J. Cardiol."},{"key":"10.1074\/jbc.M505223200_bib12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0008-6363(99)00370-3","volume":"45","author":"Singh","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1074\/jbc.M505223200_bib13","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1161\/01.CIR.97.9.892","volume":"97","author":"Ju","year":"1998","journal-title":"Circulation."},{"key":"10.1074\/jbc.M505223200_bib14","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1161\/01.RES.87.12.1180","volume":"87","author":"Adams","year":"2000","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M505223200_bib15","doi-asserted-by":"crossref","first-page":"40343","DOI":"10.1074\/jbc.M305964200","volume":"278","author":"Howes","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M505223200_bib16","doi-asserted-by":"crossref","first-page":"H139","DOI":"10.1152\/ajpcell.2000.279.3.C603","volume":"279","author":"Mitarai","year":"2000","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M505223200_bib17","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1074\/jbc.M006825200","volume":"276","author":"Di Lisa","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M505223200_bib18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1126\/science.1081208","volume":"300","author":"Scorrano","year":"2003","journal-title":"Science."},{"key":"10.1074\/jbc.M505223200_bib19","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1073\/pnas.052713199","volume":"99","author":"Korge","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M505223200_bib20","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/hh2201.100205","volume":"89","author":"Murata","year":"2001","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M505223200_bib21","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/01.RES.0000051861.21316.E9","volume":"92","author":"Akao","year":"2003","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M505223200_bib22","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S1471-4914(03)00046-7","volume":"9","author":"Mattson","year":"2003","journal-title":"Trends Mol. Med."},{"key":"10.1074\/jbc.M505223200_bib23","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1161\/01.RES.0000087542.26971.D4","volume":"93","author":"Weiss","year":"2003","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M505223200_bib24","doi-asserted-by":"crossref","first-page":"12030","DOI":"10.1074\/jbc.M010604200","volume":"276","author":"Petronilli","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M505223200_bib25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0165-2478(98)00013-3","volume":"61","author":"Metivier","year":"1998","journal-title":"Immunol. Lett."},{"key":"10.1074\/jbc.M505223200_bib26","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/415198a","volume":"415","author":"Bers","year":"2002","journal-title":"Nature."},{"key":"10.1074\/jbc.M505223200_bib27","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1023\/A:1006810523586","volume":"184","author":"Di Lisa","year":"1998","journal-title":"Mol. Cell. Biochem."},{"key":"10.1074\/jbc.M505223200_bib28","doi-asserted-by":"crossref","first-page":"15305","DOI":"10.1074\/jbc.275.20.15305","volume":"275","author":"Szalai","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M505223200_bib29","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1091\/mbc.11.5.1845","volume":"11","author":"Jaconi","year":"2000","journal-title":"Mol. Biol. Cell."},{"key":"10.1074\/jbc.M505223200_bib30","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1050-1738(01)00123-2","volume":"11","author":"Csord\u00e1s","year":"2001","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1074\/jbc.M505223200_bib31","doi-asserted-by":"crossref","first-page":"C817","DOI":"10.1152\/ajpcell.00139.2004","volume":"287","author":"Brookes","year":"2004","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M505223200_bib32","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1161\/01.CIR.0000130647.29030.90","volume":"109","author":"Uchiyama","year":"2004","journal-title":"Circulation."},{"key":"10.1074\/jbc.M505223200_bib33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0303-7207(03)00200-4","volume":"205","author":"Lai","year":"2003","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1074\/jbc.M505223200_bib34","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/01.RES.0000124394.01180.BE","volume":"94","author":"Shiraishi","year":"2004","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M505223200_bib35","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1093\/emboj\/20.15.4107","volume":"20","author":"Pacher","year":"2001","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M505223200_bib36","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2004.11.049","volume":"120","author":"Bano","year":"2005","journal-title":"Cell."},{"key":"10.1074\/jbc.M505223200_bib37","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1172\/JCI200316738","volume":"111","author":"Song","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M505223200_bib38","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/01.RES.85.11.1009","volume":"85","author":"Pogwizd","year":"1999","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M505223200_bib39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/A:1006824623496","volume":"188","author":"Golfman","year":"1998","journal-title":"Mol. Cell. Biochem."},{"key":"10.1074\/jbc.M505223200_bib40","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1469-7793.2000.00085.x","volume":"527","author":"Hattori","year":"2000","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M505223200_bib41","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0008-6363(01)00470-9","volume":"53","author":"Sipido","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1074\/jbc.M505223200_bib42","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/01.RES.0000142316.08250.68","volume":"95","author":"Henderson","year":"2004","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M505223200_bib43","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/01.CIR.101.6.660","volume":"101","author":"Fujio","year":"2000","journal-title":"Circulation."},{"key":"10.1074\/jbc.M505223200_bib44","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1161\/01.CIR.100.23.2373","volume":"100","author":"Matsui","year":"1999","journal-title":"Circulation."},{"key":"10.1074\/jbc.M505223200_bib45","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1161\/01.CIR.104.3.330","volume":"104","author":"Matsui","year":"2001","journal-title":"Circulation."},{"key":"10.1074\/jbc.M505223200_bib46","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1085\/jgp.78.5.457","volume":"78","author":"Fabiato","year":"1981","journal-title":"J. Gen. Physiol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819377130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819377130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M505223200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T10:13:54Z","timestamp":1641118434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819377130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":46,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0021925819377130"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m505223200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}