{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:57:41Z","timestamp":1790866661728,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":5361,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1074\/jbc.m507336200","type":"journal-article","created":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T01:17:56Z","timestamp":1134091076000},"page":"6559-6572","source":"Crossref","is-referenced-by-count":37,"title":["Determination of the Substrate Specificity of Tripeptidyl-peptidase I Using Combinatorial Peptide Libraries and Development of Improved Fluorogenic Substrates"],"prefix":"10.1016","volume":"281","author":[{"given":"Yu","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Sohar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lobel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M507336200_bib1","series-title":"The Neuronal Ceroid Lipofuscinoses (Batten Disease): Biomedical and Health Research","year":"1999"},{"key":"10.1074\/jbc.M507336200_bib2","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0021-9258(17)36006-4","volume":"261","author":"Palmer","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M507336200_bib3","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1126\/science.277.5333.1802","volume":"277","author":"Sleat","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M507336200_bib4","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1046\/j.1471-4159.1999.0730700.x","volume":"73","author":"Sohar","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M507336200_bib5","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0167-4838(98)00238-6","volume":"1429","author":"Rawlings","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M507336200_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0014-5793(98)01683-4","volume":"443","author":"Vines","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M507336200_bib7","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1074\/jbc.M008562200","volume":"276","author":"Lin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M507336200_bib8","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0969-2126(02)00772-4","volume":"10","author":"Comellas-Bigler","year":"2002","journal-title":"Structure (Camb.)"},{"key":"10.1074\/jbc.M507336200_bib9","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/87610","volume":"8","author":"Wlodawer","year":"2001","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M507336200_bib10","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1006\/bbrc.2000.2207","volume":"268","author":"Ezaki","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M507336200_bib11","doi-asserted-by":"crossref","first-page":"31058","DOI":"10.1074\/jbc.M400700200","volume":"279","author":"Golabek","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M507336200_bib12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/1531-8249(200002)47:2<254::AID-ANA19>3.0.CO;2-7","volume":"47","author":"Berry-Kravis","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M507336200_bib13","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/clinchem\/46.7.1005","volume":"46","author":"Sohar","year":"2000","journal-title":"Clin. Chem."},{"issue":"Suppl. A","key":"10.1074\/jbc.M507336200_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1053\/ejpn.2000.0437","volume":"5","author":"Junaid","year":"2001","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"10.1074\/jbc.M507336200_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/1097-0223(200102)21:2<99::AID-PD988>3.0.CO;2-F","volume":"21","author":"Kleijer","year":"2001","journal-title":"Prenatal. Diagn."},{"key":"10.1074\/jbc.M507336200_bib16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1373\/49.3.509","volume":"49","author":"Lukacs","year":"2003","journal-title":"Clin. Chem."},{"key":"10.1074\/jbc.M507336200_bib17","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/ajmg.1320420428","volume":"42","author":"Palmer","year":"1992","journal-title":"Am. J. Med. Genet."},{"key":"10.1074\/jbc.M507336200_bib18","doi-asserted-by":"crossref","first-page":"5736","DOI":"10.1016\/S0021-9258(18)83610-9","volume":"264","author":"Palmer","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M507336200_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1055\/s-2007-973666","volume":"28","author":"Palmer","year":"1997","journal-title":"Neuropediatrics"},{"key":"10.1074\/jbc.M507336200_bib20","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1042\/bj2680751","volume":"268","author":"Fearnley","year":"1990","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M507336200_bib21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199704000-00005","volume":"56","author":"Tyynela","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1074\/jbc.M507336200_bib22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1750-3639.2000.tb00255.x","volume":"10","author":"Herva","year":"2000","journal-title":"Brain Pathol."},{"key":"10.1074\/jbc.M507336200_bib23","series-title":"Handbook of Proteolytic Enzymes","first-page":"1893","author":"Sohar","year":"2003"},{"key":"10.1074\/jbc.M507336200_bib24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0006-291X(85)90571-6","volume":"126","author":"McDonald","year":"1985","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M507336200_bib25","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1210\/endo-103-5-1794","volume":"103","author":"Doebber","year":"1978","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M507336200_bib26","first-page":"869","volume":"27","author":"Watanabe","year":"1992","journal-title":"Biochem. Int."},{"key":"10.1074\/jbc.M507336200_bib27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0014-5793(01)02608-4","volume":"500","author":"Warburton","year":"2001","journal-title":"FEBS Lett."},{"issue":"Suppl. A","key":"10.1074\/jbc.M507336200_bib28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1053\/ejpn.2000.0436","volume":"5","author":"Sleat","year":"2001","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"10.1074\/jbc.M507336200_bib29","doi-asserted-by":"crossref","first-page":"7754","DOI":"10.1073\/pnas.140132697","volume":"97","author":"Harris","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M507336200_bib30","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1021\/jo016140o","volume":"67","author":"Maly","year":"2002","journal-title":"J. Org. Chem."},{"key":"10.1074\/jbc.M507336200_bib31","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1002\/bip.360341212","volume":"34","author":"Ostresh","year":"1994","journal-title":"Biopolymers"},{"key":"10.1074\/jbc.M507336200_bib32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0076-6879(95)48005-6","volume":"248","author":"McGeehan","year":"1995","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M507336200_bib33","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0003-2697(70)90146-6","volume":"34","author":"Kaiser","year":"1970","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M507336200_bib34","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1034\/j.1399-3011.2002.02988.x","volume":"59","author":"Tian","year":"2002","journal-title":"J. Pept. Res."},{"key":"10.1074\/jbc.M507336200_bib35","doi-asserted-by":"crossref","first-page":"9117","DOI":"10.1523\/JNEUROSCI.2729-04.2004","volume":"24","author":"Sleat","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M507336200_bib36","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/jb\/mvi110","volume":"138","author":"Oyama","year":"2005","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1074\/jbc.M507336200_bib37","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1472-6807-3-8","volume":"3","author":"Wlodawer","year":"2003","journal-title":"BMC Struct. Biol."},{"key":"10.1074\/jbc.M507336200_bib38","series-title":"Lysosomes","first-page":"73","author":"Holtzman","year":"1989"},{"key":"10.1074\/jbc.M507336200_bib39","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/oxfordjournals.jbchem.a022781","volume":"128","author":"Ezaki","year":"2000","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1074\/jbc.M507336200_bib40","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/nbdi.1999.0267","volume":"6","author":"Mitchison","year":"1999","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M507336200_bib41","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1042\/bj3340547","volume":"334","author":"Sleat","year":"1998","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M507336200_bib42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bbrc.2004.04.142","volume":"319","author":"Kopan","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M507336200_bib43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0304-3940(02)00841-8","volume":"331","author":"Warburton","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1074\/jbc.M507336200_bib44","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1042\/bj20020467","volume":"366","author":"Bernardini","year":"2002","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M507336200_bib45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0301-2115(98)00333-9","volume":"281","author":"Junaid","year":"1999","journal-title":"Clin. Chim. Acta"},{"key":"10.1074\/jbc.M507336200_bib46","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/humu.1170","volume":"18","author":"Lin","year":"2001","journal-title":"Hum. Mutat."},{"key":"10.1074\/jbc.M507336200_bib47","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1086\/302427","volume":"64","author":"Sleat","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1074\/jbc.M507336200_bib48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0006-291X(67)80055-X","volume":"27","author":"Schechter","year":"1967","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819580140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819580140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M507336200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T22:59:40Z","timestamp":1641164380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819580140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0021925819580140"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m507336200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}