{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:57:59Z","timestamp":1792677479131,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"40","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":5470,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1074\/jbc.m507928200","type":"journal-article","created":{"date-parts":[[2005,8,9]],"date-time":"2005-08-09T00:14:15Z","timestamp":1123546455000},"page":"34056-34062","source":"Crossref","is-referenced-by-count":83,"title":["Anthrax Biosensor, Protective Antigen Ion Channel Asymmetric Blockade"],"prefix":"10.1016","volume":"280","author":[{"given":"Kelly M.","family":"Halverson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha G.","family":"Panchal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam L.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Gussio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Misakian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Bavari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Kasianowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M507928200_bib2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/n35101999","volume":"414","author":"Bradley","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M507928200_bib3","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1073\/pnas.0431098100","volume":"100","author":"Scobie","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M507928200_bib4","doi-asserted-by":"crossref","first-page":"16396","DOI":"10.1016\/S0021-9258(18)42016-9","volume":"267","author":"Molloy","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M507928200_bib5","doi-asserted-by":"crossref","first-page":"10277","DOI":"10.1073\/pnas.89.21.10277","volume":"89","author":"Klimpel","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M507928200_bib6","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/385833a0","volume":"385","author":"Petosa","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M507928200_bib7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0966-842X(02)02369-7","volume":"10","author":"Mourez","year":"2002","journal-title":"Trends Microbiol."},{"key":"10.1074\/jbc.M507928200_bib8","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1365-2958.1993.tb00936.x","volume":"10","author":"Milne","year":"1993","journal-title":"Mol. Microbiol."},{"issue":"Pt. 3","key":"10.1074\/jbc.M507928200_bib9","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1099\/13500872-142-3-707","volume":"142","author":"Little","year":"1996","journal-title":"Microbiology"},{"key":"10.1074\/jbc.M507928200_bib10","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1128\/iai.56.7.1807-1813.1988","volume":"56","author":"Little","year":"1988","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M507928200_bib11","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1073\/pnas.69.12.3561","volume":"69","author":"Montal","year":"1972","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M507928200_bib12","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0006-3495(95)79879-4","volume":"69","author":"Kasianowicz","year":"1995","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.M507928200_bib13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nsmb711","volume":"11","author":"Panchal","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1074\/jbc.M507928200_bib14","doi-asserted-by":"crossref","first-page":"10834","DOI":"10.1074\/jbc.M412210200","volume":"280","author":"Panchal","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M507928200_bib15","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1085\/jgp.96.5.943","volume":"96","author":"Blaustein","year":"1990","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.M507928200_bib16","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1085\/jgp.96.5.921","volume":"96","author":"Blaustein","year":"1990","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.M507928200_bib17","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1085\/jgp.96.5.905","volume":"96","author":"Blaustein","year":"1990","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.M507928200_bib18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0300-483X(94)90153-8","volume":"87","author":"Finkelstein","year":"1994","journal-title":"Toxicology"},{"key":"10.1074\/jbc.M507928200_bib19","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1529\/biophysj.104.050864","volume":"87","author":"Zhang","year":"2004","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.M507928200_bib20","doi-asserted-by":"crossref","first-page":"18626","DOI":"10.1074\/jbc.270.31.18626","volume":"270","author":"Zhao","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M507928200_bib21","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1128\/IAI.67.4.1853-1859.1999","volume":"67","author":"Singh","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M507928200_bib22","series-title":"Sourcebook of Bacterial Protein Toxins","first-page":"277","author":"Leppla","year":"1991"},{"key":"10.1074\/jbc.M507928200_bib23","doi-asserted-by":"crossref","first-page":"20124","DOI":"10.1016\/S0021-9258(18)54899-7","volume":"266","author":"Quinn","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M507928200_bib24","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1021\/bi000310u","volume":"39","author":"Elliott","year":"2000","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M507928200_bib25","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1099\/00221287-138-3-543","volume":"138","author":"Ezzell","year":"1992","journal-title":"J. Gen. Microbiol."},{"key":"10.1074\/jbc.M507928200_bib26","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1021\/bi972657b","volume":"37","author":"Benson","year":"1998","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M507928200_bib27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/07391102.2004.10531226","volume":"22","author":"Nguyen","year":"2004","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1074\/jbc.M507928200_bib28","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1126\/science.274.5294.1859","volume":"274","author":"Song","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.M507928200_bib29","doi-asserted-by":"crossref","first-page":"13770","DOI":"10.1073\/pnas.93.24.13770","volume":"93","author":"Kasianowicz","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M507928200_bib30","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1021\/ac000958c","volume":"73","author":"Kasianowicz","year":"2001","journal-title":"Anal. Chem."},{"key":"10.1074\/jbc.M507928200_bib31","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0092-8674(91)90455-8","volume":"65","author":"Simon","year":"1991","journal-title":"Cell"},{"key":"10.1074\/jbc.M507928200_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev.physiol.66.032102.150822","volume":"66","author":"Lu","year":"2004","journal-title":"Annu. Rev. Physiol."},{"key":"10.1074\/jbc.M507928200_bib33","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1128\/IAI.70.8.4477-4484.2002","volume":"70","author":"Chauhan","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M507928200_bib34","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1073\/pnas.062160399","volume":"99","author":"Cunningham","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M507928200_bib35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/n35101998","volume":"414","author":"Pannifer","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M507928200_bib1","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1001\/jama.287.17.2236","volume":"287","author":"Inglesby","year":"2002","journal-title":"J. Am. Med. Assoc."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820789921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820789921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M507928200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T18:23:36Z","timestamp":1641407016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820789921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":35,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["S0021925820789921"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m507928200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}