{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:17:17Z","timestamp":1789755437149,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":5356,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1074\/jbc.m509052200","type":"journal-article","created":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T01:12:57Z","timestamp":1134004377000},"page":"4199-4206","source":"Crossref","is-referenced-by-count":38,"title":["Chronic Wasting Disease of Elk and Deer and Creutzfeldt-Jakob Disease"],"prefix":"10.1016","volume":"281","author":[{"given":"Zhiliang","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine I.","family":"O'Rourke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqian","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen L.","family":"Jenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Langenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermias D.","family":"Belay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence B.","family":"Schonberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenquan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingzhong","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Gambetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu G.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M509052200_bib1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.7589\/0090-3558-16.1.89","volume":"16","author":"Williams","year":"1980","journal-title":"J. Wildl. Dis."},{"key":"10.1074\/jbc.M509052200_bib2","series-title":"Prion Biology and Diseases","first-page":"545","author":"Prusiner","year":"2004"},{"key":"10.1074\/jbc.M509052200_bib3","first-page":"193","volume":"284","author":"Miller","year":"2004","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1074\/jbc.M509052200_bib4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0272-2712(02)00040-9","volume":"23","author":"Williams","year":"2003","journal-title":"Clin. Lab. Med."},{"key":"10.1074\/jbc.M509052200_bib5","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1354\/vp.39-1-110","volume":"39","author":"Spraker","year":"2002","journal-title":"Vet. Pathol."},{"key":"10.1074\/jbc.M509052200_bib6","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1354\/vp.39-5-546","volume":"39","author":"Spraker","year":"2002","journal-title":"Vet. Pathol."},{"key":"10.1074\/jbc.M509052200_bib7","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s004010100417","volume":"102","author":"Liberski","year":"2001","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1074\/jbc.M509052200_bib8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/030098589303000105","volume":"30","author":"Williams","year":"1993","journal-title":"Vet. Pathol."},{"key":"10.1074\/jbc.M509052200_bib9","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1177\/104063870001200618","volume":"12","author":"Peters","year":"2000","journal-title":"J. Vet. Diagn. Investig."},{"issue":"Pt. 10","key":"10.1074\/jbc.M509052200_bib10","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1099\/0022-1317-82-10-2327","volume":"82","author":"Sigurdson","year":"2001","journal-title":"J. Gen. Virol."},{"key":"10.1074\/jbc.M509052200_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/425035a","volume":"425","author":"Miller","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M509052200_bib12","doi-asserted-by":"crossref","first-page":"E121","DOI":"10.1371\/journal.pbio.0020121","volume":"2","author":"Bunk","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1074\/jbc.M509052200_bib13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.20506\/rst.21.2.1340","volume":"21","author":"Williams","year":"2002","journal-title":"Rev. Sci. Tech."},{"key":"10.1074\/jbc.M509052200_bib14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/viro.1998.9427","volume":"251","author":"Bartz","year":"1998","journal-title":"Virology"},{"key":"10.1074\/jbc.M509052200_bib15","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3201\/eid1006.031082","volume":"10","author":"Belay","year":"2004","journal-title":"Emerg. Infect. Dis."},{"key":"10.1074\/jbc.M509052200_bib16","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W","volume":"46","author":"Parchi","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M509052200_bib17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/bmb\/66.1.255","volume":"66","author":"Will","year":"2003","journal-title":"Br. Med. Bull."},{"key":"10.1074\/jbc.M509052200_bib18","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/ana.20127","volume":"55","author":"Head","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M509052200_bib19","doi-asserted-by":"crossref","first-page":"15137","DOI":"10.1073\/pnas.96.26.15137","volume":"96","author":"Scott","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"448\u2013450","key":"10.1074\/jbc.M509052200_bib20","first-page":"526","volume":"389","author":"Hill","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M509052200_bib21","doi-asserted-by":"crossref","first-page":"8812","DOI":"10.1073\/pnas.95.15.8812","volume":"95","author":"Zanusso","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M509052200_bib22","doi-asserted-by":"crossref","first-page":"10168","DOI":"10.1073\/pnas.97.18.10168","volume":"97","author":"Parchi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M509052200_bib23","doi-asserted-by":"crossref","first-page":"40429","DOI":"10.1074\/jbc.M308550200","volume":"278","author":"Zou","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M509052200_bib24","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1110\/ps.39201","volume":"10","author":"Peretz","year":"2001","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M509052200_bib25","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1073\/pnas.0307825100","volume":"101","author":"Zou","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M509052200_bib26","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0003-9861(87)90380-8","volume":"258","author":"Bolton","year":"1987","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.M509052200_bib27","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nm0997-1009","volume":"3","author":"Chen","year":"1997","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M509052200_bib28","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/ana.410390613","volume":"39","author":"Parchi","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M509052200_bib29","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/2654","volume":"4","author":"Safar","year":"1998","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M509052200_bib30","series-title":"Prion Biology and Diseases","first-page":"434","author":"Scott","year":"2004"},{"key":"10.1074\/jbc.M509052200_bib31","series-title":"Prion Biology and Diseases","first-page":"629","author":"Will","year":"2004"},{"key":"10.1074\/jbc.M509052200_bib32","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1750-3639.1996.tb00869.x","volume":"6","author":"Ironside","year":"1996","journal-title":"Brain Pathol."},{"key":"10.1074\/jbc.M509052200_bib33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1750-3639.1995.tb00580.x","volume":"5","author":"Wells","year":"1995","journal-title":"Brain Pathol."},{"key":"10.1074\/jbc.M509052200_bib34","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/383685a0","volume":"383","author":"Collinge","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M509052200_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/bmb\/66.1.213","volume":"66","author":"Gambetti","year":"2003","journal-title":"Br. Med. Bull."},{"key":"10.1074\/jbc.M509052200_bib36","doi-asserted-by":"crossref","first-page":"12365","DOI":"10.1128\/JVI.76.23.12365-12368.2002","volume":"76","author":"Race","year":"2002","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M509052200_bib37","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1073\/pnas.0305777101","volume":"101","author":"Casalone","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M509052200_bib38","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/386232a0","volume":"386","author":"Parchi","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M509052200_bib39","doi-asserted-by":"crossref","first-page":"7944","DOI":"10.1523\/JNEUROSCI.2467-05.2005","volume":"25","author":"Kong","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M509052200_bib40","doi-asserted-by":"crossref","first-page":"13794","DOI":"10.1128\/JVI.79.21.13794-13796.2005","volume":"79","author":"Marsh","year":"2005","journal-title":"J. Virol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819484032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819484032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M509052200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T19:12:15Z","timestamp":1641150735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819484032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0021925819484032"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m509052200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}