{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:39:15Z","timestamp":1790937555707,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T00:00:00Z","timestamp":1605312000000},"content-version":"vor","delay-in-days":5400,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1074\/jbc.m509145200","type":"journal-article","created":{"date-parts":[[2005,12,23]],"date-time":"2005-12-23T20:13:33Z","timestamp":1135368813000},"page":"5037-5041","source":"Crossref","is-referenced-by-count":46,"title":["Formation of Tau Inclusions in Knock-in Mice with Familial Alzheimer Disease (FAD) Mutation of Presenilin 1 (PS1)"],"prefix":"10.1016","volume":"281","author":[{"given":"Kentaro","family":"Tanemura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du-Hua","family":"Chui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Mi","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Tatebayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Miyasaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Hashikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M509145200_bib1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M509145200_bib2","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1093\/hmg\/4.12.2363","volume":"4","author":"Cruts","year":"1995","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M509145200_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.crvi.2004.10.013","volume":"328","author":"St George-Hyslop","year":"2005","journal-title":"C. R. Biol."},{"key":"10.1074\/jbc.M509145200_bib4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0006-3223(99)00301-7","volume":"47","author":"St George-Hyslop","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1074\/jbc.M509145200_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0304-3940(97)00417-5","volume":"229","author":"Murayama","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1074\/jbc.M509145200_bib6","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nm0896-864","volume":"2","author":"Scheuner","year":"1996","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M509145200_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nm0198-097","volume":"4","author":"Holcomb","year":"1998","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M509145200_bib8","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S1385-299X(00)00031-3","volume":"6","author":"Chang","year":"2000","journal-title":"Brain Res. Brain Res. Protoc."},{"key":"10.1074\/jbc.M509145200_bib9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1749-6632.1999.tb07845.x","volume":"893","author":"Klein","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1074\/jbc.M509145200_bib10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s004419900109","volume":"298","author":"Morelli","year":"1999","journal-title":"Cell Tissue Res."},{"key":"10.1074\/jbc.M509145200_bib11","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1080\/1071576021000049890","volume":"36","author":"Butterfield","year":"2002","journal-title":"Free Radic. Res."},{"key":"10.1074\/jbc.M509145200_bib12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0896-6273(01)00417-2","volume":"31","author":"Yu","year":"2001","journal-title":"Neuron"},{"key":"10.1074\/jbc.M509145200_bib13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/nbdi.2001.0473","volume":"9","author":"Amtul","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M509145200_bib14","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/ana.20083","volume":"55","author":"Dermaut","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M509145200_bib15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000058328","volume":"14","author":"Tang-Wai","year":"2002","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1074\/jbc.M509145200_bib16","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/00001756-200204160-00036","volume":"13","author":"Evin","year":"2002","journal-title":"Neuroreport"},{"key":"10.1074\/jbc.M509145200_bib17","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s11910-001-0100-0","volume":"1","author":"Yoshiyama","year":"2001","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1074\/jbc.M509145200_bib18","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1093\/brain\/122.9.1709","volume":"122","author":"Gomez-Isla","year":"1999","journal-title":"Brain"},{"key":"10.1074\/jbc.M509145200_bib19","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1046\/j.1460-9568.1999.00698.x","volume":"11","author":"Nakano","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1074\/jbc.M509145200_bib20","doi-asserted-by":"crossref","first-page":"9637","DOI":"10.1073\/pnas.95.16.9637","volume":"95","author":"Takashima","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M509145200_bib21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1006\/abio.1993.1018","volume":"208","author":"Van Lint","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M509145200_bib22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0197-4580(91)90022-C","volume":"12","author":"Iqbal","year":"1991","journal-title":"Neurobiol. Aging"},{"key":"10.1074\/jbc.M509145200_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0197-4580(01)00265-2","volume":"23","author":"Sun","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"10.1074\/jbc.M509145200_bib24","doi-asserted-by":"crossref","first-page":"13896","DOI":"10.1073\/pnas.202205599","volume":"99","author":"Tatebayashi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M509145200_bib25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1523\/JNEUROSCI.22-01-00133.2002","volume":"22","author":"Tanemura","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M509145200_bib26","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature01832","volume":"424","author":"Liou","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M509145200_bib27","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1126\/science.1899488","volume":"251","author":"Lee","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.M509145200_bib28","doi-asserted-by":"crossref","first-page":"42060","DOI":"10.1074\/jbc.M202241200","volume":"277","author":"Sato","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M509145200_bib29","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0896-6273(03)00627-5","volume":"40","author":"Cruz","year":"2003","journal-title":"Neuron"},{"key":"10.1074\/jbc.M509145200_bib30","doi-asserted-by":"crossref","first-page":"8717","DOI":"10.1523\/JNEUROSCI.20-23-08717.2000","volume":"20","author":"Siman","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M509145200_bib31","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1046\/j.1471-4159.1999.0721019.x","volume":"72","author":"Guo","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M509145200_bib32","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1038\/sj.emboj.7600251","volume":"23","author":"Baki","year":"2004","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M509145200_bib33","doi-asserted-by":"crossref","first-page":"31537","DOI":"10.1074\/jbc.M500833200","volume":"280","author":"Kang","year":"2005","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819768021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819768021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M509145200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T16:38:16Z","timestamp":1641227896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819768021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0021925819768021"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m509145200","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.8137.465625","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}