{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:17:42Z","timestamp":1791206262589,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":5361,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1074\/jbc.m510118200","type":"journal-article","created":{"date-parts":[[2005,12,27]],"date-time":"2005-12-27T01:13:11Z","timestamp":1135645991000},"page":"6334-6348","source":"Crossref","is-referenced-by-count":35,"title":["A Point Mutation in NEMO Associated with Anhidrotic Ectodermal Dysplasia with Immunodeficiency Pathology Results in Destabilization of the Oligomer and Reduces Lipopolysaccharide- and Tumor Necrosis Factor-mediated NF-\u03baB Activation"],"prefix":"10.1016","volume":"281","author":[{"given":"Emilie","family":"Vinolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Sebban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Chaffotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Isra\u00ebl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Courtois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"V\u00e9ron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Agou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M510118200_bib1","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1101\/gad.1228704","volume":"18","author":"Hayden","year":"2004","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M510118200_bib2","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1007\/s00018-005-5031-5","volume":"62","author":"Courtois","year":"2005","journal-title":"Cell Mol. Life Sci."},{"key":"10.1074\/jbc.M510118200_bib3","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/35013114","volume":"405","author":"Smahi","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M510118200_bib4","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/hmg\/10.19.2171","volume":"10","author":"Aradhya","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M510118200_bib5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/85837","volume":"27","author":"Doffinger","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M510118200_bib6","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1086\/316914","volume":"67","author":"Zonana","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1074\/jbc.M510118200_bib7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/85277","volume":"2","author":"Jain","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1074\/jbc.M510118200_bib8","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.jaci.2004.06.052","volume":"114","author":"Orange","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1074\/jbc.M510118200_bib9","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.jaci.2004.08.047","volume":"114","author":"Niehues","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1074\/jbc.M510118200_bib10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0092-8674(00)80406-7","volume":"91","author":"Zandi","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M510118200_bib11","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0092-8674(00)81466-X","volume":"93","author":"Yamaoka","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M510118200_bib12","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1101\/gad.14.7.854","volume":"14","author":"Rudolph","year":"2000","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M510118200_bib13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.it.2004.03.008","volume":"25","author":"Bonizzi","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1074\/jbc.M510118200_bib14","doi-asserted-by":"crossref","first-page":"27823","DOI":"10.1074\/jbc.M003415200","volume":"275","author":"Inohara","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510118200_bib15","doi-asserted-by":"crossref","first-page":"37966","DOI":"10.1074\/jbc.M006643200","volume":"275","author":"Poyet","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510118200_bib16","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1074\/jbc.C000792200","volume":"276","author":"Poyet","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510118200_bib17","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S0014-5793(02)03590-1","volume":"531","author":"Huang","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M510118200_bib18","doi-asserted-by":"crossref","first-page":"24445","DOI":"10.1074\/jbc.C000777200","volume":"276","author":"Carter","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510118200_bib19","doi-asserted-by":"crossref","first-page":"24331","DOI":"10.1074\/jbc.M201393200","volume":"277","author":"Prajapati","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510118200_bib20","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nature01802","volume":"424","author":"Kovalenko","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M510118200_bib21","doi-asserted-by":"crossref","first-page":"37297","DOI":"10.1074\/jbc.M303389200","volume":"278","author":"Tang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510118200_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nature02273","volume":"427","author":"Zhou","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M510118200_bib23","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.cub.2004.12.032","volume":"14","author":"Abbott","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M510118200_bib24","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/26261","volume":"395","author":"Rothwarf","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M510118200_bib25","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1126\/science.289.5484.1550","volume":"289","author":"May","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M510118200_bib26","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.1128\/MCB.22.18.6573-6581.2002","volume":"22","author":"Makris","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M510118200_bib27","doi-asserted-by":"crossref","first-page":"17464","DOI":"10.1074\/jbc.M201964200","volume":"277","author":"Agou","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510118200_bib28","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1128\/MCB.23.6.2029-2041.2003","volume":"23","author":"Tegethoff","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M510118200_bib29","doi-asserted-by":"crossref","first-page":"27861","DOI":"10.1074\/jbc.M314278200","volume":"279","author":"Agou","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510118200_bib30","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.4049\/jimmunol.172.4.2446","volume":"172","author":"Yang","year":"2004","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M510118200_bib31","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1128\/MCB.22.16.5813-5825.2002","volume":"22","author":"Huang","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M510118200_bib32","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nature01803","volume":"424","author":"Trompouki","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M510118200_bib33","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0003-2697(89)90602-7","volume":"182","author":"Gill","year":"1989","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M510118200_bib34","series-title":"Analytical Ultracentrifugation in Biochemistry and Polymer Science","year":"1992"},{"key":"10.1074\/jbc.M510118200_bib35","series-title":"Modern Analytical Ultracentrifugation","first-page":"37","author":"Johnson","year":"1994"},{"key":"10.1074\/jbc.M510118200_bib36","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0003-2697(82)90400-6","volume":"125","author":"Hennessey","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M510118200_bib37","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1006\/abio.1993.1079","volume":"209","author":"Sreerama","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M510118200_bib38","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/(SICI)1097-0134(20000201)38:2<226::AID-PROT10>3.0.CO;2-H","volume":"38","author":"Receveur","year":"2000","journal-title":"Proteins"},{"key":"10.1074\/jbc.M510118200_bib39","doi-asserted-by":"crossref","first-page":"47285","DOI":"10.1074\/jbc.M106550200","volume":"276","author":"Ferri-Fioni","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510118200_bib40","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1093\/hmg\/ddh192","volume":"13","author":"Fusco","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M510118200_bib41","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1038\/sj.onc.1203445","volume":"19","author":"Harhaj","year":"2000","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M510118200_bib42","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/bip.360310111","volume":"31","author":"Semisotnov","year":"1991","journal-title":"Biopolymers"},{"key":"10.1074\/jbc.M510118200_bib43","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1016\/S0021-9258(18)45932-7","volume":"267","author":"Zhou","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510118200_bib44","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/nar\/gkg161","volume":"31","author":"Krishna","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M510118200_bib45","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1006\/jmbi.1994.1250","volume":"237","author":"Zhou","year":"1994","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M510118200_bib46","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0014-5793(78)80948-X","volume":"94","author":"Szabo","year":"1978","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M510118200_bib47","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1046\/j.1432-1327.2000.01095.x","volume":"267","author":"Matthews","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M510118200_bib48","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1021\/bi00302a032","volume":"23","author":"Pundak","year":"1984","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M510118200_bib49","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1021\/bi00303a047","volume":"23","author":"Corbett","year":"1984","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M510118200_bib50","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0076-6879(00)28402-4","volume":"328","author":"Muller","year":"2000","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M510118200_bib51","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/356453a0","volume":"356","author":"Serrano","year":"1992","journal-title":"Nature"},{"key":"10.1074\/jbc.M510118200_bib52","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0022-2836(02)00699-X","volume":"321","author":"Dragan","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M510118200_bib53","doi-asserted-by":"crossref","first-page":"14480","DOI":"10.1021\/bi961831d","volume":"35","author":"Boice","year":"1996","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M510118200_bib54","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0969-2126(00)00527-X","volume":"8","author":"Liew","year":"2000","journal-title":"Structure"},{"key":"10.1074\/jbc.M510118200_bib55","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0022-2836(92)90103-Q","volume":"225","author":"Jasanoff","year":"1992","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M510118200_bib56","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1006\/jmbi.2001.5335","volume":"316","author":"Lachenmann","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M510118200_bib57","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/(SICI)1098-1004(199912)14:6<466::AID-HUMU4>3.0.CO;2-6","volume":"14","author":"Kohsaka","year":"1999","journal-title":"Hum. Mutat."},{"key":"10.1074\/jbc.M510118200_bib58","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nature02263","volume":"426","author":"Goldberg","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M510118200_bib59","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0092-8674(00)00126-4","volume":"103","author":"Deng","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.M510118200_bib60","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0092-8674(03)00895-X","volume":"115","author":"Huang","year":"2003","journal-title":"Cell"},{"key":"10.1074\/jbc.M510118200_bib61","doi-asserted-by":"crossref","first-page":"9882","DOI":"10.1074\/jbc.275.13.9882","volume":"275","author":"Ye","year":"2000","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819579893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819579893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M510118200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T22:58:58Z","timestamp":1641164338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819579893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0021925819579893"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m510118200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}