{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:01:00Z","timestamp":1789992060578,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":5388,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1074\/jbc.m510472200","type":"journal-article","created":{"date-parts":[[2005,11,11]],"date-time":"2005-11-11T01:12:56Z","timestamp":1131671576000},"page":"714-722","source":"Crossref","is-referenced-by-count":53,"title":["Trypsin Cleaves Acid-sensing Ion Channel 1a in a Domain That Is Critical for Channel Gating"],"prefix":"10.1016","volume":"281","author":[{"given":"Marija","family":"Vukicevic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Weder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Boillat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Boesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kellenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M510472200_bib1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0959-4388(98)80070-6","volume":"8","author":"Waldmann","year":"1998","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1074\/jbc.M510472200_bib2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0166-2236(03)00210-8","volume":"26","author":"Krishtal","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M510472200_bib3","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1152\/physrev.00007.2002","volume":"82","author":"Kellenberger","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M510472200_bib4","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1073\/pnas.98.2.711","volume":"98","author":"Sutherland","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M510472200_bib5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0304-3959(03)00269-0","volume":"106","author":"Sluka","year":"2003","journal-title":"Pain"},{"key":"10.1074\/jbc.M510472200_bib6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0896-6273(02)00661-X","volume":"34","author":"Wemmie","year":"2002","journal-title":"Neuron"},{"key":"10.1074\/jbc.M510472200_bib7","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1523\/JNEUROSCI.23-13-05496.2003","volume":"23","author":"Wemmie","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M510472200_bib8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2004.08.026","volume":"118","author":"Xiong","year":"2004","journal-title":"Cell"},{"key":"10.1074\/jbc.M510472200_bib9","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1113\/jphysiol.2001.014837","volume":"539","author":"Baron","year":"2002","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M510472200_bib10","doi-asserted-by":"crossref","first-page":"C682","DOI":"10.1152\/ajpcell.00127.2004","volume":"287","author":"Vukicevic","year":"2004","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M510472200_bib11","doi-asserted-by":"crossref","first-page":"38448","DOI":"10.1074\/jbc.M407381200","volume":"279","author":"Poirot","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510472200_bib12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jneumeth.2004.11.012","volume":"144","author":"Neaga","year":"2005","journal-title":"J. Neurosci. Meth."},{"key":"10.1074\/jbc.M510472200_bib13","doi-asserted-by":"crossref","first-page":"33782","DOI":"10.1074\/jbc.M104030200","volume":"276","author":"Bassler","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510472200_bib14","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1073\/pnas.96.7.4170","volume":"96","author":"Kellenberger","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M510472200_bib15","doi-asserted-by":"crossref","first-page":"25116","DOI":"10.1074\/jbc.M003643200","volume":"275","author":"Escoubas","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510472200_bib16","doi-asserted-by":"crossref","first-page":"10240","DOI":"10.1073\/pnas.95.17.10240","volume":"95","author":"Chen","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M510472200_bib17","series-title":"Handbook of Proteolytic Enzymes","author":"Barrett","year":"1998"},{"key":"10.1074\/jbc.M510472200_bib18","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1021\/cr000033x","volume":"102","author":"Hedstrom","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1074\/jbc.M510472200_bib19","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1021\/cr010182v","volume":"102","author":"Powers","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1074\/jbc.M510472200_bib20","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1681\/ASN.V133588","volume":"13","author":"Vallet","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1074\/jbc.M510472200_bib21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/386173a0","volume":"386","author":"Waldmann","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M510472200_bib22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1085\/jgp.200509303","volume":"126","author":"Chen","year":"2005","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.M510472200_bib23","doi-asserted-by":"crossref","first-page":"45240","DOI":"10.1074\/jbc.M304441200","volume":"278","author":"Coric","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510472200_bib24","doi-asserted-by":"crossref","first-page":"20975","DOI":"10.1074\/jbc.272.34.20975","volume":"272","author":"Waldmann","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510472200_bib25","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/00004647-200005000-00001","volume":"20","author":"Vivien","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1074\/jbc.M510472200_bib26","doi-asserted-by":"crossref","first-page":"23004","DOI":"10.1074\/jbc.273.36.23004","volume":"273","author":"Davies","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510472200_bib27","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0002-9440(10)65635-0","volume":"153","author":"Koshikawa","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.M510472200_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0009-8981(03)00004-4","volume":"329","author":"Yousef","year":"2003","journal-title":"Clin. Chim. Acta"},{"key":"10.1074\/jbc.M510472200_bib29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1006\/mcne.1997.0616","volume":"9","author":"Gschwend","year":"1997","journal-title":"Mol. Cell Neurosci."},{"key":"10.1074\/jbc.M510472200_bib30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0166-2236(00)01617-9","volume":"23","author":"Gingrich","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M510472200_bib31","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1152\/physrev.1999.79.4.1431","volume":"79","author":"Lipton","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M510472200_bib32","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1152\/physrev.00010.2003","volume":"83","author":"Chesler","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M510472200_bib33","doi-asserted-by":"crossref","first-page":"30204","DOI":"10.1074\/jbc.273.46.30204","volume":"273","author":"Adams","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510472200_bib34","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1085\/jgp.116.6.781","volume":"116","author":"Snyder","year":"2000","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.M510472200_bib35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1113\/jphysiol.2002.022020","volume":"543","author":"Kellenberger","year":"2002","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M510472200_bib36","doi-asserted-by":"crossref","first-page":"41597","DOI":"10.1074\/jbc.M205877200","volume":"277","author":"Babini","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M510472200_bib37","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1113\/jphysiol.2005.087734","volume":"568","author":"Coric","year":"2005","journal-title":"J. Physiol. (Lond)"},{"key":"10.1074\/jbc.M510472200_bib38","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1074\/jbc.274.5.2743","volume":"274","author":"Firsov","year":"1999","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819475091?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819475091?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M510472200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T18:50:03Z","timestamp":1641149403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819475091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0021925819475091"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m510472200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}