{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:35:39Z","timestamp":1777437339795,"version":"3.51.4"},"reference-count":60,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"vor","delay-in-days":5352,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1074\/jbc.m512932200","type":"journal-article","created":{"date-parts":[[2005,12,23]],"date-time":"2005-12-23T01:13:03Z","timestamp":1135300383000},"page":"6924-6930","source":"Crossref","is-referenced-by-count":43,"title":["Inhibition or Activation of Apert Syndrome FGFR2 (S252W) Signaling by Specific Glycosaminoglycans"],"prefix":"10.1016","volume":"281","author":[{"given":"Lynda M.","family":"McDowell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth A.","family":"Frazier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R.","family":"Studelska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Giljum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Ornitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M512932200_bib1","first-page":"321","volume":"57","author":"Park","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1074\/jbc.M512932200_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/ng0295-165","volume":"9","author":"Wilkie","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M512932200_bib3","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1086\/302245","volume":"64","author":"Oldridge","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1074\/jbc.M512932200_bib4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1034\/j.1399-0004.2000.570208.x","volume":"57","author":"von Gernet","year":"2000","journal-title":"Clin. Genet."},{"key":"10.1074\/jbc.M512932200_bib5","first-page":"923","volume":"58","author":"Slaney","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"10.1074\/jbc.M512932200_bib6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/01.PRS.0000146703.08958.95","volume":"115","author":"Ibrahimi","year":"2005","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1074\/jbc.M512932200_bib7","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1073\/pnas.121183798","volume":"98","author":"Ibrahimi","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M512932200_bib8","doi-asserted-by":"crossref","first-page":"14536","DOI":"10.1073\/pnas.97.26.14536","volume":"97","author":"Yu","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M512932200_bib9","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1073\/pnas.081082498","volume":"98","author":"Yu","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M512932200_bib10","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1242\/dev.01914","volume":"132","author":"Wang","year":"2005","journal-title":"Development (Camb.)"},{"key":"10.1074\/jbc.M512932200_bib11","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1242\/dev.126.17.3715","volume":"126","author":"Lin","year":"1999","journal-title":"Development (Camb.)"},{"key":"10.1074\/jbc.M512932200_bib12","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(91)90512-W","volume":"64","author":"Yayon","year":"1991","journal-title":"Cell"},{"key":"10.1074\/jbc.M512932200_bib13","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1126\/science.1646484","volume":"252","author":"Rapraeger","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.M512932200_bib14","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1242\/dev.01935","volume":"132","author":"Grobe","year":"2005","journal-title":"Development (Camb.)"},{"key":"10.1074\/jbc.M512932200_bib15","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0092-8674(03)00715-3","volume":"114","author":"Garcia-Garcia","year":"2003","journal-title":"Cell"},{"key":"10.1074\/jbc.M512932200_bib16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/(SICI)1521-1878(200002)22:2<108::AID-BIES2>3.0.CO;2-M","volume":"22","author":"Ornitz","year":"2000","journal-title":"BioEssays"},{"key":"10.1074\/jbc.M512932200_bib17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/dbio.2000.9798","volume":"224","author":"Lin","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1074\/jbc.M512932200_bib18","doi-asserted-by":"crossref","first-page":"5055","DOI":"10.1242\/dev.02088","volume":"132","author":"Stickens","year":"2005","journal-title":"Development (Camb.)"},{"key":"10.1074\/jbc.M512932200_bib19","doi-asserted-by":"crossref","first-page":"23906","DOI":"10.1016\/S0021-9258(20)80471-2","volume":"268","author":"Guimond","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib20","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0960-9822(00)80060-3","volume":"9","author":"Guimond","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M512932200_bib21","doi-asserted-by":"crossref","first-page":"22936","DOI":"10.1074\/jbc.273.36.22936","volume":"273","author":"Pye","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib22","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1074\/jbc.M410412200","volume":"280","author":"Taylor","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib23","doi-asserted-by":"crossref","first-page":"42815","DOI":"10.1074\/jbc.M204959200","volume":"277","author":"Trowbridge","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib24","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/hmg\/ddh235","volume":"13","author":"Ibrahimi","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M512932200_bib25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI200113530","volume":"108","author":"Esko","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M512932200_bib26","doi-asserted-by":"crossref","first-page":"9451","DOI":"10.1016\/S0021-9258(19)50108-9","volume":"267","author":"Yanagishita","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib27","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/23488","volume":"400","author":"Forsberg","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M512932200_bib28","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/23481","volume":"400","author":"Humphries","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M512932200_bib29","doi-asserted-by":"crossref","first-page":"28116","DOI":"10.1074\/jbc.273.43.28116","volume":"273","author":"Penc","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib30","doi-asserted-by":"crossref","first-page":"15874","DOI":"10.1016\/S0021-9258(18)55480-6","volume":"265","author":"Edge","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib31","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.sbi.2003.09.011","volume":"13","author":"Sugahara","year":"2003","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1074\/jbc.M512932200_bib32","doi-asserted-by":"crossref","first-page":"32193","DOI":"10.1074\/jbc.M503645200","volume":"280","author":"Bergefall","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib33","first-page":"79","volume":"171","author":"Shworak","year":"2001","journal-title":"Methods Mol. Biol."},{"key":"10.1074\/jbc.M512932200_bib34","doi-asserted-by":"crossref","first-page":"16305","DOI":"10.1016\/S0021-9258(18)42001-7","volume":"267","author":"Ornitz","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/glycob\/cwj037","volume":"16","author":"Studelska","year":"2006","journal-title":"Glycobiology"},{"key":"10.1074\/jbc.M512932200_bib36","doi-asserted-by":"crossref","first-page":"42817","DOI":"10.1074\/jbc.M504338200","volume":"280","author":"Chen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib37","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1073\/pnas.072651899","volume":"99","author":"Rusnati","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M512932200_bib38","doi-asserted-by":"crossref","first-page":"24653","DOI":"10.1074\/jbc.M908930199","volume":"275","author":"Lundin","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib39","doi-asserted-by":"crossref","first-page":"25949","DOI":"10.1074\/jbc.M004140200","volume":"275","author":"Kariya","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib40","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1002\/j.1460-2075.1995.tb07212.x","volume":"14","author":"Gao","year":"1995","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M512932200_bib41","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1126\/science.7536345","volume":"268","author":"Ornitz","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.M512932200_bib42","doi-asserted-by":"crossref","first-page":"7184","DOI":"10.1128\/MCB.22.20.7184-7192.2002","volume":"22","author":"Yeh","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M512932200_bib43","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1126\/science.8456318","volume":"259","author":"Kan","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M512932200_bib44","doi-asserted-by":"crossref","first-page":"17121","DOI":"10.1074\/jbc.M212590200","volume":"278","author":"Wu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib45","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S1097-2765(00)00073-3","volume":"6","author":"Schlessinger","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M512932200_bib46","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/35039551","volume":"407","author":"Pellegrini","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M512932200_bib47","doi-asserted-by":"crossref","first-page":"42274","DOI":"10.1074\/jbc.M505720200","volume":"280","author":"Robinson","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib48","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.sbi.2005.09.002","volume":"15","author":"Mohammadi","year":"2005","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1074\/jbc.M512932200_bib49","doi-asserted-by":"crossref","first-page":"15292","DOI":"10.1074\/jbc.271.25.15292","volume":"271","author":"Ornitz","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib50","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1055\/s-2007-1001928","volume":"20","author":"Olson","year":"1994","journal-title":"Semin. Thromb. Hemostasis"},{"key":"10.1074\/jbc.M512932200_bib51","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.1021\/bi0352320","volume":"43","author":"Ibrahimi","year":"2004","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M512932200_bib52","doi-asserted-by":"crossref","first-page":"15947","DOI":"10.1074\/jbc.274.22.15947","volume":"274","author":"Kan","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib53","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1083\/jcb.200307053","volume":"163","author":"Allen","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M512932200_bib54","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1126\/science.293.5535.1663","volume":"293","author":"Dhoot","year":"2001","journal-title":"Science"},{"key":"10.1074\/jbc.M512932200_bib55","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1172\/JCI13662","volume":"108","author":"Vlodavsky","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M512932200_bib56","doi-asserted-by":"crossref","first-page":"49175","DOI":"10.1074\/jbc.M205131200","volume":"277","author":"Morimoto-Tomita","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib57","doi-asserted-by":"crossref","first-page":"5604","DOI":"10.1074\/jbc.M310691200","volume":"279","author":"Viviano","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib58","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1073\/pnas.0401028101","volume":"101","author":"Wang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M512932200_bib59","doi-asserted-by":"crossref","first-page":"40066","DOI":"10.1074\/jbc.M508136200","volume":"280","author":"Dai","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M512932200_bib60","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1074\/jbc.M108540200","volume":"277","author":"Ostrovsky","year":"2002","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819353074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819353074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M512932200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:23:55Z","timestamp":1683332635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819353074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":60,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0021925819353074"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m512932200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}