{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:25:15Z","timestamp":1791653115314,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":5258,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1074\/jbc.m600364200","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T02:17:37Z","timestamp":1141784257000},"page":"14474-14485","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":407,"title":["Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1"],"prefix":"10.1016","volume":"281","author":[{"given":"Mamoru","family":"Shibata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Furuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Degterev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Mizushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamotsu","family":"Yoshimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcy","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Yankner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junying","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M600364200_bib1","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1093\/brain\/awh278","volume":"127","author":"Everett","year":"2004","journal-title":"Brain"},{"key":"10.1074\/jbc.M600364200_bib2","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1172\/JCI20039","volume":"112","author":"Qu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M600364200_bib3","doi-asserted-by":"crossref","first-page":"15077","DOI":"10.1073\/pnas.2436255100","volume":"100","author":"Yue","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M600364200_bib4","first-page":"Pe48","author":"MacDonald","year":"2003","journal-title":"Sci. STKE 2003"},{"key":"10.1074\/jbc.M600364200_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1006\/nbdi.1998.0168","volume":"4","author":"Becher","year":"1998","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M600364200_bib6","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M600364200_bib7","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1523\/JNEUROSCI.19-07-02522.1999","volume":"19","author":"Gutekunst","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M600364200_bib8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature01301","volume":"421","author":"Sanchez","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M600364200_bib9","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nm985","volume":"10","author":"Tanaka","year":"2004","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M600364200_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1097-2765(04)00151-0","volume":"14","author":"Venkatraman","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M600364200_bib11","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1093\/hmg\/ddg346","volume":"12","author":"Qin","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M600364200_bib12","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/hmg\/11.9.1107","volume":"11","author":"Ravikumar","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M600364200_bib13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/ng1362","volume":"36","author":"Ravikumar","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M600364200_bib14","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1534-5807(04)00099-1","volume":"6","author":"Levine","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1074\/jbc.M600364200_bib15","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1091\/mbc.e03-09-0704","volume":"15","author":"Mizushima","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M600364200_bib16","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.1099993","volume":"306","author":"Shintani","year":"2004","journal-title":"Science"},{"key":"10.1074\/jbc.M600364200_bib17","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","volume":"290","author":"Klionsly","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M600364200_bib18","doi-asserted-by":"crossref","first-page":"22284","DOI":"10.1074\/jbc.273.35.22284","volume":"273","author":"Kametaka","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M600364200_bib19","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/45257","volume":"402","author":"Liang","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M600364200_bib20","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1093\/hmg\/9.19.2799","volume":"9","author":"Trettel","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M600364200_bib21","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/ng0696-196","volume":"13","author":"Ikeda","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M600364200_bib22","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1074\/jbc.C000752200","volume":"276","author":"Tanida","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M600364200_bib23","first-page":"8586","volume":"72","author":"Liang","year":"1998","journal-title":"J. Viol."},{"key":"10.1074\/jbc.M600364200_bib24","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0092-8674(00)80514-0","volume":"90","author":"Scherzinger","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M600364200_bib25","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1146\/annurev.nu.07.070187.002543","volume":"7","author":"Mortimore","year":"1987","journal-title":"Annu. Rev. Nutr."},{"key":"10.1074\/jbc.M600364200_bib26","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1074\/jbc.270.5.2320","volume":"270","author":"Blommaart","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M600364200_bib27","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1074\/jbc.275.2.992","volume":"275","author":"Petiot","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M600364200_bib28","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","volume":"19","author":"Kabeya","year":"2000","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M600364200_bib29","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1242\/jcs.01131","volume":"117","author":"Kabeya","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M600364200_bib30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tig.2004.01.008","volume":"20","author":"Li","year":"2004","journal-title":"Trends Genet."},{"key":"10.1074\/jbc.M600364200_bib31","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.1093\/emboj\/20.21.5971","volume":"20","author":"Suzuki","year":"2001","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M600364200_bib32","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1083\/jcb.152.3.519","volume":"152","author":"Kihara","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M600364200_bib33","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","volume":"87","author":"Mangiriani","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.M600364200_bib34","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","volume":"90","author":"Davies","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M600364200_bib35","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1083\/jcb.200412022","volume":"169","author":"Komatsu","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M600364200_bib36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1006\/geno.1999.5851","volume":"59","author":"Aita","year":"1999","journal-title":"Genomics"},{"key":"10.1074\/jbc.M600364200_bib37","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2005.07.002","volume":"122","author":"Pattingre","year":"2005","journal-title":"Cell"},{"key":"10.1074\/jbc.M600364200_bib38","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nature02661","volume":"429","author":"Lu","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M600364200_bib39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1023\/B:MCBI.0000041848.57020.57","volume":"263","author":"Cuervo","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1074\/jbc.M600364200_bib40","doi-asserted-by":"crossref","first-page":"B375","DOI":"10.1093\/gerona\/56.9.B375","volume":"56","author":"Donati","year":"2001","journal-title":"J. Gerontol. A. Biol. Sci. Med. Sci."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820780956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820780956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M600364200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T17:46:30Z","timestamp":1641404790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820780956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":40,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0021925820780956"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m600364200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M600364200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2006 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}