{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:37:35Z","timestamp":1790498255601,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"29","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":5213,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1074\/jbc.m600565200","type":"journal-article","created":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T00:42:44Z","timestamp":1147740164000},"page":"20326-20337","source":"Crossref","is-referenced-by-count":92,"title":["Resurgent Current and Voltage Sensor Trapping Enhanced Activation by a \u03b2-Scorpion Toxin Solely in Nav1.6 Channel"],"prefix":"10.1016","volume":"281","author":[{"given":"Emanuele","family":"Schiavon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Sacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita Restano","family":"Cassulini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Gurrola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Tempia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourival D.","family":"Possani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Wanke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M600565200_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)81133-2","volume":"26","author":"Catterall","year":"2000","journal-title":"Neuron"},{"key":"10.1074\/jbc.M600565200_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0896-6273(00)80680-7","volume":"22","author":"Cha","year":"1999","journal-title":"Neuron"},{"key":"10.1074\/jbc.M600565200_bib3","doi-asserted-by":"crossref","first-page":"15950","DOI":"10.1074\/jbc.271.27.15950","volume":"271","author":"Rogers","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M600565200_bib4","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0896-6273(00)80606-6","volume":"21","author":"Cest\u00e8le","year":"1998","journal-title":"Neuron"},{"key":"10.1074\/jbc.M600565200_bib5","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0300-9084(00)01174-3","volume":"82","author":"Cest\u00e8le","year":"2000","journal-title":"Biochimie (Paris)"},{"key":"10.1074\/jbc.M600565200_bib6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1085\/jgp.118.3.291","volume":"118","author":"Cest\u00e8le","year":"2001","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.M600565200_bib7","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1113\/jphysiol.1975.sp010810","volume":"244","author":"Cahalan","year":"1975","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M600565200_bib8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF00582392","volume":"393","author":"Meves","year":"1982","journal-title":"Pfluegers. Arch."},{"key":"10.1074\/jbc.M600565200_bib9","first-page":"519","volume":"23","author":"Wang","year":"1983","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M600565200_bib10","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1523\/JNEUROSCI.17-12-04517.1997","volume":"17","author":"Raman","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M600565200_bib11","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0896-6273(00)80969-1","volume":"19","author":"Raman","year":"1997","journal-title":"Neuron"},{"key":"10.1074\/jbc.M600565200_bib12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuron.2004.12.035","volume":"25","author":"Grieco","year":"2005","journal-title":"Neuron"},{"key":"10.1074\/jbc.M600565200_bib13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/jmbi.1999.2611","volume":"287","author":"Pintar","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M600565200_bib14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1432-1033.1992.tb16635.x","volume":"204","author":"Zamudio","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M600565200_bib15","first-page":"334","volume":"79","author":"Rochat","year":"1984","journal-title":"J. Physiol. (Paris)"},{"key":"10.1074\/jbc.M600565200_bib16","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1016\/S0021-9258(18)61214-1","volume":"262","author":"Martin","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M600565200_bib17","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1093\/nar\/gkg520","volume":"31","author":"Schwede","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M600565200_bib18","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/381272a0","volume":"381","author":"Hooft","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M600565200_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0263-7855(96)00009-4","volume":"14","author":"Koradi","year":"1996","journal-title":"J. Mol. Graphics"},{"key":"10.1074\/jbc.M600565200_bib20","doi-asserted-by":"crossref","first-page":"33323","DOI":"10.1074\/jbc.M404344200","volume":"279","author":"Oliveira","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M600565200_bib21","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1096\/fj.02-0200fje","volume":"17","author":"Gullo","year":"2003","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M600565200_bib22","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1002\/j.1460-2075.1995.tb07091.x","volume":"14","author":"Klugbauer","year":"1995","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M600565200_bib23","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1146\/annurev.physiol.63.1.871","volume":"63","author":"Goldin","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"10.1074\/jbc.M600565200_bib24","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0169-328X(02)00188-2","volume":"103","author":"Burbidge","year":"2002","journal-title":"Mol. Brain Res."},{"key":"10.1074\/jbc.M600565200_bib25","series-title":"Ionic channels of Excitable Membranes","first-page":"635","author":"Hille","year":"2001"},{"key":"10.1074\/jbc.M600565200_bib26","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1113\/jphysiol.1980.sp013357","volume":"305","author":"Llinas","year":"1980","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1074\/jbc.M600565200_bib27","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1113\/jphysiol.2002.022525","volume":"543","author":"Sacco","year":"2002","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1074\/jbc.M600565200_bib28","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.1523\/JNEUROSCI.18-16-06093.1998","volume":"18","author":"Smith","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M600565200_bib29","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1113\/jphysiol.2003.047357","volume":"551","author":"Herzog","year":"2003","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M600565200_bib30","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0006-3495(01)76052-3","volume":"80","author":"Raman","year":"2001","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.M600565200_bib31","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1073\/pnas.090034797","volume":"97","author":"Caldwell","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M600565200_bib32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/(SICI)1096-9861(20000424)420:1<84::AID-CNE6>3.0.CO;2-9","volume":"420","author":"Schaller","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1074\/jbc.M600565200_bib33","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0896-6273(94)90335-2","volume":"12","author":"Kuo","year":"1994","journal-title":"Neuron"},{"key":"10.1074\/jbc.M600565200_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0896-6273(01)00265-3","volume":"30","author":"Boiko","year":"2001","journal-title":"Neuron"},{"key":"10.1074\/jbc.M600565200_bib35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/(SICI)1096-9861(20000424)420:1<70::AID-CNE5>3.0.CO;2-P","volume":"420","author":"Krzemien","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1074\/jbc.M600565200_bib36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1113\/jphysiol.2005.093484","volume":"568","author":"Mantegazza","year":"2005","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M600565200_bib37","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0014-5793(00)01518-0","volume":"473","author":"Moran","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M600565200_bib38","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1074\/jbc.M408427200","volume":"280","author":"Cohen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M600565200_bib39","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1046\/j.1432-1327.1999.00620.x","volume":"264","author":"Calder\u00f3n-Aranda","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M600565200_bib40","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0041-0101(96)00043-8","volume":"34","author":"Licea","year":"1996","journal-title":"Toxicon"},{"key":"10.1074\/jbc.M600565200_bib41","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/(SICI)1097-0134(19991001)37:1<130::AID-PROT13>3.0.CO;2-S","volume":"37","author":"Selisko","year":"1999","journal-title":"Proteins"},{"key":"10.1074\/jbc.M600565200_bib42","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0166-2236(90)90110-V","volume":"13","author":"DeLong","year":"1990","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M600565200_bib43","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/brain\/121.3.451","volume":"121","author":"Krack","year":"1998","journal-title":"Brain"},{"key":"10.1074\/jbc.M600565200_bib44","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.neuron.2004.11.023","volume":"44","author":"Drouot","year":"2004","journal-title":"Neuron"},{"key":"10.1074\/jbc.M600565200_bib45","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1152\/jn.2001.85.4.1351","volume":"85","author":"Beurrier","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1074\/jbc.M600565200_bib46","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0896-6273(03)00360-X","volume":"39","author":"Do","year":"2003","journal-title":"Neuron"},{"key":"10.1074\/jbc.M600565200_bib47","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1152\/jn.00186.2004","volume":"92","author":"Do","year":"2004","journal-title":"J. Neurophysiol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819763479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819763479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M600565200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T05:39:51Z","timestamp":1625809191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819763479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":47,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S0021925819763479"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m600565200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}