{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:01:29Z","timestamp":1791406889546,"version":"4.3.3"},"reference-count":55,"publisher":"Elsevier BV","issue":"26","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":5226,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1074\/jbc.m601679200","type":"journal-article","created":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T00:18:11Z","timestamp":1146183491000},"page":"17890-17899","source":"Crossref","is-referenced-by-count":106,"title":["Cholesterol Accumulation Sequesters Rab9 and Disrupts Late Endosome Function in NPC1-deficient Cells"],"prefix":"10.1016","volume":"281","author":[{"given":"Ian G.","family":"Ganley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne R.","family":"Pfeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M601679200_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbalip.2004.08.009","volume":"1685","author":"Mukherjee","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M601679200_bib2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbalip.2004.08.014","volume":"1685","author":"Sturley","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M601679200_bib3","doi-asserted-by":"crossref","first-page":"20917","DOI":"10.1074\/jbc.R400040200","volume":"280","author":"Chang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M601679200_bib4","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1074\/jbc.273.7.4266","volume":"273","author":"Underwood","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M601679200_bib5","doi-asserted-by":"crossref","first-page":"14850","DOI":"10.1074\/jbc.M300488200","volume":"278","author":"Wojtanik","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M601679200_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/mgme.1999.2882","volume":"68","author":"Higgins","year":"1999","journal-title":"Mol. Genet. Metab."},{"key":"10.1074\/jbc.M601679200_bib7","doi-asserted-by":"crossref","first-page":"9627","DOI":"10.1074\/jbc.274.14.9627","volume":"274","author":"Neufeld","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M601679200_bib8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.277.5323.228","volume":"277","author":"Carstea","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M601679200_bib9","doi-asserted-by":"crossref","first-page":"12473","DOI":"10.1073\/pnas.0405255101","volume":"101","author":"Ohgami","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M601679200_bib10","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.tibs.2005.07.007","volume":"30","author":"Ioannou","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M601679200_bib11","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1126\/science.290.5500.2298","volume":"290","author":"Naureckiene","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M601679200_bib12","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1073\/pnas.0530027100","volume":"100","author":"Ko","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M601679200_bib13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.bi.61.070192.001515","volume":"61","author":"Kornfeld","year":"1992","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M601679200_bib14","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nrm1050","volume":"4","author":"Ghosh","year":"2003","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1074\/jbc.M601679200_bib15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/j.1460-2075.1993.tb05701.x","volume":"12","author":"Lombardi","year":"1993","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M601679200_bib16","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1083\/jcb.125.3.573","volume":"125","author":"Riederer","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M601679200_bib17","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0092-8674(00)81171-X","volume":"93","author":"Diaz","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M601679200_bib18","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1126\/science.1056791","volume":"292","author":"Carroll","year":"2001","journal-title":"Science"},{"key":"10.1074\/jbc.M601679200_bib19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1083\/jcb.138.2.283","volume":"138","author":"Diaz","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M601679200_bib20","doi-asserted-by":"crossref","first-page":"27737","DOI":"10.1074\/jbc.272.44.27737","volume":"272","author":"Itin","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M601679200_bib21","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1091\/mbc.10.7.2191","volume":"10","author":"Itin","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M601679200_bib22","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/emboj\/21.6.1289","volume":"21","author":"Lebrand","year":"2002","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M601679200_bib23","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1091\/mbc.12.3.601","volume":"12","author":"Ko","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M601679200_bib24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/10084","volume":"1","author":"Kobayashi","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M601679200_bib25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1194\/jlr.M200230-JLR200","volume":"44","author":"Walter","year":"2003","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M601679200_bib26","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1172\/JCI0215420","volume":"109","author":"Choudhury","year":"2002","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M601679200_bib27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0076-6879(95)57030-6","volume":"257","author":"Soldati","year":"1995","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M601679200_bib28","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/S0021-9258(19)39980-6","volume":"265","author":"Sasaki","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M601679200_bib29","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1091\/mbc.e04-08-0747","volume":"15","author":"Ganley","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M601679200_bib30","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1083\/jcb.200109030","volume":"156","author":"Barbero","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M601679200_bib31","doi-asserted-by":"crossref","first-page":"6343","DOI":"10.1073\/pnas.1037853100","volume":"100","author":"Chi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M601679200_bib32","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1194\/jlr.D200036-JLR200","volume":"44","author":"Sugii","year":"2003","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M601679200_bib33","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1016\/S0021-9258(18)69086-6","volume":"263","author":"Sokol","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M601679200_bib34","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.1073\/pnas.85.21.8022","volume":"85","author":"Blanchette-Mackie","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M601679200_bib35","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1083\/jcb.108.5.1625","volume":"108","author":"Liscum","year":"1989","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M601679200_bib36","doi-asserted-by":"crossref","first-page":"11041","DOI":"10.1073\/pnas.96.20.11041","volume":"96","author":"Brown","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Suppl. B","key":"10.1074\/jbc.M601679200_bib37","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/eurheartj\/13.suppl_B.34","volume":"13","author":"Goldstein","year":"1992","journal-title":"Eur. Heart J."},{"key":"10.1074\/jbc.M601679200_bib38","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1034\/j.1600-0854.2003.00072.x","volume":"4","author":"Mobius","year":"2003","journal-title":"Traffic"},{"key":"10.1074\/jbc.M601679200_bib39","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0962-8924(01)02147-X","volume":"11","author":"Pfeffer","year":"2001","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.M601679200_bib40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/35052055","volume":"2","author":"Zerial","year":"2001","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1074\/jbc.M601679200_bib41","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1091\/mbc.e04-05-0432","volume":"15","author":"Choudhury","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M601679200_bib42","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1083\/jcb.130.6.1297","volume":"130","author":"Rohrer","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M601679200_bib43","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1242\/jcs.106.3.823","volume":"106","author":"Schimmoller","year":"1993","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M601679200_bib44","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1083\/jcb.140.5.1075","volume":"140","author":"Press","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M601679200_bib45","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1083\/jcb.131.6.1435","volume":"131","author":"Feng","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M601679200_bib46","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0076-6879(01)29078-8","volume":"329","author":"Feng","year":"2001","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M601679200_bib47","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nature04399","volume":"438","author":"Maxfield","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M601679200_bib48","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbamem.2004.05.012","volume":"1666","author":"Lee","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M601679200_bib49","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s002329900397","volume":"164","author":"Brown","year":"1998","journal-title":"J. Membr. Biol."},{"key":"10.1074\/jbc.M601679200_bib50","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1083\/jcb.121.5.997","volume":"121","author":"Klumperman","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M601679200_bib51","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1242\/jcs.114.9.1765","volume":"114","author":"Miwako","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M601679200_bib52","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1074\/jbc.274.6.3910","volume":"274","author":"Melkonian","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M601679200_bib53","doi-asserted-by":"crossref","first-page":"13031","DOI":"10.1021\/bi0112311","volume":"40","author":"Wang","year":"2001","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M601679200_bib54","doi-asserted-by":"crossref","first-page":"27180","DOI":"10.1074\/jbc.M300542200","volume":"278","author":"Sugii","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M601679200_bib55","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1091\/mbc.e02-01-0025","volume":"13","author":"Holtta-Vuori","year":"2002","journal-title":"Mol. Biol. Cell"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820556615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820556615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M601679200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T14:39:09Z","timestamp":1639838349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820556615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":55,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0021925820556615"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m601679200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}