{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:01:50Z","timestamp":1792047710622,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"35","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":5158,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1074\/jbc.m605273200","type":"journal-article","created":{"date-parts":[[2006,6,28]],"date-time":"2006-06-28T01:27:47Z","timestamp":1151458067000},"page":"25447-25456","source":"Crossref","is-referenced-by-count":75,"title":["Rheb Inhibits C-Raf Activity and B-Raf\/C-Raf Heterodimerization"],"prefix":"10.1016","volume":"281","author":[{"given":"Magdalena","family":"Karbowniczek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin P.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Petri","family":"Henske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M605273200_bib1","first-page":"3595","volume":"61","author":"Weber","year":"2001","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M605273200_bib2","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.molcel.2005.10.022","volume":"20","author":"Garnett","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M605273200_bib3","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nrm1498","volume":"5","author":"Wellbrock","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M605273200_bib4","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nature00766","volume":"417","author":"Davies","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M605273200_bib5","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1158\/0008-5472.CAN-05-0115","volume":"66","author":"Zebisch","year":"2006","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M605273200_bib6","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1126\/science.1124642","volume":"311","author":"Rodriguez-Viciana","year":"2006","journal-title":"Science"},{"key":"10.1074\/jbc.M605273200_bib7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/ng1748","volume":"38","author":"Schubbert","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M605273200_bib8","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/ng1749","volume":"38","author":"Niihori","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M605273200_bib9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00120-005-0982-6","volume":"45","author":"Staehler","year":"2006","journal-title":"Urologe. A."},{"key":"10.1074\/jbc.M605273200_bib10","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.1200\/JCO.2005.08.036","volume":"23","author":"Beeram","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1074\/jbc.M605273200_bib11","doi-asserted-by":"crossref","first-page":"6356","DOI":"10.1038\/sj.onc.1205792","volume":"21","author":"Im","year":"2002","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M605273200_bib12","doi-asserted-by":"crossref","first-page":"29930","DOI":"10.1074\/jbc.M402591200","volume":"279","author":"Karbowniczek","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M605273200_bib13","doi-asserted-by":"crossref","first-page":"16333","DOI":"10.1016\/S0021-9258(17)34012-7","volume":"269","author":"Yamagata","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M605273200_bib14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/ncb995","volume":"5","author":"Stocker","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M605273200_bib15","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/ncb996","volume":"5","author":"Saucedo","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M605273200_bib16","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ncb999","volume":"5","author":"Zhang","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M605273200_bib17","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0960-9822(03)00506-2","volume":"13","author":"Tee","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M605273200_bib18","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1101\/gad.1110003","volume":"17","author":"Inoki","year":"2003","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M605273200_bib19","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S1097-2765(03)00220-X","volume":"11","author":"Garami","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M605273200_bib20","doi-asserted-by":"crossref","first-page":"32493","DOI":"10.1074\/jbc.C300226200","volume":"278","author":"Castro","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M605273200_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0092-8674(94)90570-3","volume":"78","author":"Sabatini","year":"1994","journal-title":"Cell"},{"key":"10.1074\/jbc.M605273200_bib22","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/369756a0","volume":"369","author":"Brown","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M605273200_bib23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0092-8674(00)00117-3","volume":"103","author":"Schmelzle","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.M605273200_bib24","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1093\/emboj\/18.8.2137","volume":"18","author":"Mason","year":"1999","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M605273200_bib25","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/24184","volume":"396","author":"King","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M605273200_bib26","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1002\/j.1460-2075.1995.tb07316.x","volume":"14","author":"Marais","year":"1995","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M605273200_bib27","first-page":"7170","volume":"13","author":"Fabian","year":"1993","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M605273200_bib28","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1093\/emboj\/20.14.3716","volume":"20","author":"Chong","year":"2001","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M605273200_bib29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0925-4773(99)00276-2","volume":"91","author":"Wojnowski","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1074\/jbc.M605273200_bib30","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0092-8674(04)00215-6","volume":"116","author":"Wan","year":"2004","journal-title":"Cell"},{"key":"10.1074\/jbc.M605273200_bib31","first-page":"6997","volume":"62","author":"Brose","year":"2002","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M605273200_bib32","doi-asserted-by":"crossref","first-page":"16244","DOI":"10.1074\/jbc.M501185200","volume":"280","author":"Tran","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M605273200_bib33","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1093\/emboj\/19.20.5429","volume":"19","author":"Zhang","year":"2000","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M605273200_bib34","doi-asserted-by":"crossref","first-page":"22917","DOI":"10.1016\/S0021-9258(17)31594-6","volume":"269","author":"Shimizu","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M605273200_bib35","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0014-5793(01)02992-1","volume":"507","author":"Mizutani","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M605273200_bib36","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0002-9440(10)63843-6","volume":"162","author":"Karbowniczek","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.M605273200_bib37","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1177\/08830738040190091201","volume":"19","author":"Astrinidis","year":"2004","journal-title":"J. Child Neurol."},{"key":"10.1074\/jbc.M605273200_bib38","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1023\/B:BIRY.0000040206.71415.6f","volume":"69","author":"Yoon","year":"2004","journal-title":"Biochemistry (Mosc.)"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819352585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819352585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M605273200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T19:41:25Z","timestamp":1639683685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819352585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":38,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0021925819352585"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m605273200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}