{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:32:27Z","timestamp":1790627547183,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"49","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":5051,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1074\/jbc.m606888200","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T00:36:10Z","timestamp":1160094970000},"page":"37904-37912","source":"Crossref","is-referenced-by-count":36,"title":["A Small Molecule Agonist of an Integrin, \u03b1L\u03b22"],"prefix":"10.1016","volume":"281","author":[{"given":"Wei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher V.","family":"Carman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minsoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azucena","family":"Salas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motomu","family":"Shimaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Springer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M606888200_bib1","first-page":"2751","author":"Anderson","year":"1989"},{"key":"10.1074\/jbc.M606888200_bib3","first-page":"117","author":"Harlan","year":"1992"},{"key":"10.1074\/jbc.M606888200_bib4","first-page":"181","volume":"36","author":"Giblin","year":"2001","journal-title":"Annu. Rep. Med. Chem."},{"key":"10.1074\/jbc.M606888200_bib8","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1001\/archderm.138.5.591","volume":"138","author":"Gottlieb","year":"2002","journal-title":"Arch. Dermatol."},{"key":"10.1074\/jbc.M606888200_bib9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1517\/14712598.3.2.361","volume":"3","author":"Cather","year":"2003","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1074\/jbc.M606888200_bib10","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1056\/NEJMoa030002","volume":"349","author":"Lebwohl","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M606888200_bib11","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/89058","volume":"7","author":"Weitz-Schmidt","year":"2001","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M606888200_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/jmbi.1999.3047","volume":"292","author":"Kallen","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M606888200_bib14","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1021\/jm000503f","volume":"44","author":"Liu","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M606888200_bib17","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1126\/science.295.5557.1086","volume":"295","author":"Gadek","year":"2002","journal-title":"Science"},{"key":"10.1074\/jbc.M606888200_bib18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/bst0280311","volume":"28","author":"Humphries","year":"2000","journal-title":"Biochem. Soc. Trans."},{"key":"10.1074\/jbc.M606888200_bib20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.biophys.31.101101.140922","volume":"31","author":"Shimaoka","year":"2002","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1074\/jbc.M606888200_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1126\/science.1064535","volume":"294","author":"Xiong","year":"2001","journal-title":"Science"},{"key":"10.1074\/jbc.M606888200_bib24","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1073\/pnas.0500200102","volume":"102","author":"Song","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M606888200_bib25","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/77978","volume":"7","author":"Shimaoka","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M606888200_bib26","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.1073\/pnas.101130498","volume":"98","author":"Shimaoka","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M606888200_bib27","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0092-8674(02)00935-2","volume":"110","author":"Takagi","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M606888200_bib30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature02976","volume":"432","author":"Xiao","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M606888200_bib31","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1084\/jem.20041850","volume":"201","author":"Semmrich","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M606888200_bib32","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0960-9822(02)00852-7","volume":"12","author":"Alonso","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M606888200_bib33","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1073\/pnas.0307340101","volume":"101","author":"Yang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M606888200_bib34","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1073\/pnas.041618598","volume":"98","author":"Lu","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M606888200_bib35","unstructured":"Fotouhi, N., Gillespie, P., Guthrie, R., Pietranico-Cole, S., and Yun, W. (October 12, 1999) International Patent WO0021920"},{"key":"10.1074\/jbc.M606888200_bib37","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1074-7613(03)00238-3","volume":"19","author":"Shimaoka","year":"2003","journal-title":"Immunity"},{"key":"10.1074\/jbc.M606888200_bib38","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1002\/j.1460-2075.1989.tb08552.x","volume":"8","author":"Dransfield","year":"1989","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M606888200_bib39","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.4049\/jimmunol.148.4.1080","volume":"148","author":"Robinson","year":"1992","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M606888200_bib40","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4049\/jimmunol.159.1.268","volume":"159","author":"Lu","year":"1997","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M606888200_bib41","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1083\/jcb.200404129","volume":"167","author":"Carman","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M606888200_bib42","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1074-7613(04)00082-2","volume":"20","author":"Salas","year":"2004","journal-title":"Immunity"},{"key":"10.1074\/jbc.M606888200_bib43","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1126\/science.1084174","volume":"301","author":"Kim","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M606888200_bib44","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1073\/pnas.97.10.5231","volume":"97","author":"Huth","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M606888200_bib45","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1073\/pnas.041606398","volume":"98","author":"Lu","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M606888200_bib46","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.4049\/jimmunol.173.6.3972","volume":"173","author":"Lu","year":"2004","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M606888200_bib47","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1110\/ps.051583406","volume":"15","author":"Keating","year":"2006","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M606888200_bib48","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/nsb1011","volume":"10","author":"Chen","year":"2003","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M606888200_bib49","series-title":"Biochemistry of Macro-phages (Ciba Symposium 118)","first-page":"102","author":"Springer","year":"1986"},{"key":"10.1074\/jbc.M606888200_bib50","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1242\/jcs.00606","volume":"116","author":"Smith","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M606888200_bib51","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/emboj\/18.3.501","volume":"18","author":"del Sanchez-Madrid","year":"1999","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M606888200_bib52","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1084\/jem.178.1.279","volume":"178","author":"Kuijpers","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M606888200_bib53","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.4049\/jimmunol.159.8.3968","volume":"159","author":"Weber","year":"1997","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M606888200_bib54","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1083\/jcb.200103048","volume":"154","author":"Worthylake","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M606888200_bib2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/346425a0","volume":"346","author":"Springer","year":"1990","journal-title":"Nature"},{"key":"10.1074\/jbc.M606888200_bib5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10001","volume":"22","author":"Yusuf-Makagiansar","year":"2002","journal-title":"Med. Res. Rev."},{"key":"10.1074\/jbc.M606888200_bib6","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0190-9622(00)90214-7","volume":"42","author":"Gottlieb","year":"2000","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1074\/jbc.M606888200_bib7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/clim.2002.5289","volume":"105","author":"Gottlieb","year":"2002","journal-title":"Clin. Immunol."},{"key":"10.1074\/jbc.M606888200_bib13","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.1021\/ja0104249","volume":"123","author":"Last-Barney","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M606888200_bib15","unstructured":"Burdick, D. J. (March 24, 1999) International Patent WO9949856"},{"key":"10.1074\/jbc.M606888200_bib16","unstructured":"Burdick, D. J., Gadek, T. R., Marsters, J., Oare, D. A., Reynolds, M. E., and Stanley, M. S. (November 26, 2001) International Patent WO02059114"},{"key":"10.1074\/jbc.M606888200_bib19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1432-1033.1997.00215.x","volume":"245","author":"Gahmberg","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M606888200_bib21","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0092-8674(95)90517-0","volume":"80","author":"Lee","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M606888200_bib22","doi-asserted-by":"crossref","first-page":"21514","DOI":"10.1074\/jbc.M002286200","volume":"275","author":"Huang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M606888200_bib28","doi-asserted-by":"crossref","first-page":"10215","DOI":"10.1074\/jbc.M312732200","volume":"279","author":"Luo","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M606888200_bib29","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1073\/pnas.0307291101","volume":"101","author":"Yang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M606888200_bib36","doi-asserted-by":"crossref","first-page":"10590","DOI":"10.1074\/jbc.M110521200","volume":"277","author":"Welzenbach","year":"2002","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820719666?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820719666?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M606888200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T06:53:24Z","timestamp":1683615204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820719666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":54,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0021925820719666"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m606888200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}