{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:00:09Z","timestamp":1789207209496,"version":"build-2803163510"},"reference-count":64,"publisher":"Elsevier BV","issue":"51","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":5067,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1074\/jbc.m607128200","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T20:37:52Z","timestamp":1160167072000},"page":"39316-39329","source":"Crossref","is-referenced-by-count":199,"title":["A Multienzyme Network Functions in Intestinal Protein Digestion by a Platyhelminth Parasite"],"prefix":"10.1016","volume":"281","author":[{"given":"Melaine","family":"Delcroix","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Sajid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor R.","family":"Caffrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee-C.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Dvo\u0159\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Bahgat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colette","family":"Dissous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"McKerrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M607128200_bib1","series-title":"Handbook of Proteolytic Enzymes, 2nd Ed.","author":"Barrett","year":"2004"},{"key":"10.1074\/jbc.M607128200_bib2","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/BF00936455","volume":"78","author":"Yamasaki","year":"1992","journal-title":"Parasitol. Res."},{"key":"10.1074\/jbc.M607128200_bib3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1017\/S0031182000065276","volume":"110","author":"Brown","year":"1995","journal-title":"Parasitol."},{"key":"10.1074\/jbc.M607128200_bib4","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1096\/fj.02-0181fje","volume":"16","author":"Williamson","year":"2002","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M607128200_bib5","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/0022-1910(94)90023-X","volume":"40","author":"Orr","year":"1994","journal-title":"J. Insect Physiol."},{"key":"10.1074\/jbc.M607128200_bib6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ibmb.2005.10.003","volume":"36","author":"Boldbaatar","year":"2006","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1074\/jbc.M607128200_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(01)00438-8","volume":"120","author":"Sajid","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1471-4922(03)00189-2","volume":"19","author":"Williamson","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1074\/jbc.M607128200_bib9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.pt.2004.03.004","volume":"20","author":"Caffrey","year":"2004","journal-title":"Trends Parasitol."},{"key":"10.1074\/jbc.M607128200_bib10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0001-706X(00)00122-4","volume":"77","author":"Chitsulo","year":"2000","journal-title":"Acta Tropica"},{"key":"10.1074\/jbc.M607128200_bib11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2307\/3277456","volume":"56","author":"Zussman","year":"1970","journal-title":"J. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib12","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ijpara.2004.01.008","volume":"34","author":"McCarthy","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0065-308X(08)60243-2","volume":"43","author":"Tort","year":"1999","journal-title":"Adv. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib14","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1128\/IAI.67.1.368-374.1999","volume":"67","author":"Brady","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M607128200_bib15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0166-6851(00)00351-0","volume":"112","author":"Brindley","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0166-6851(96)02703-X","volume":"81","author":"Wasilewski","year":"1996","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib17","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1242\/jeb.01749","volume":"208","author":"Lara","year":"2005","journal-title":"J. Exp. Biol."},{"key":"10.1074\/jbc.M607128200_bib18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2307\/3283643","volume":"78","author":"Bogitsh","year":"1992","journal-title":"J. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0169-4758(96)80676-4","volume":"12","author":"Dalton","year":"1996","journal-title":"Parasitol. Today"},{"key":"10.1074\/jbc.M607128200_bib20","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1017\/S0031182000086248","volume":"55","author":"Smithers","year":"1965","journal-title":"Parasitology"},{"key":"10.1074\/jbc.M607128200_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2307\/3280632","volume":"67","author":"Basch","year":"1981","journal-title":"J. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1042\/bj3320499","volume":"332","author":"Xing","year":"1998","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M607128200_bib23","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0014-4894(86)90148-7","volume":"61","author":"Chappell","year":"1986","journal-title":"Exp. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib24","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M607128200_bib25","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0076-6879(81)80043-2","volume":"80","author":"Barrett","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M607128200_bib26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1042\/bj2010189","volume":"201","author":"Barrett","year":"1982","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M607128200_bib27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0014-5793(91)80318-W","volume":"25","author":"Murata","year":"1991","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M607128200_bib28","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/oxfordjournals.jbchem.a022396","volume":"125","author":"Yasuda","year":"1999","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1074\/jbc.M607128200_bib29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.7164\/antibiotics.23.259","volume":"23","author":"Umezawa","year":"1970","journal-title":"J. Antibiotics"},{"key":"10.1074\/jbc.M607128200_bib30","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1006\/abbi.1993.1274","volume":"303","author":"Kembhavi","year":"1993","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.M607128200_bib31","doi-asserted-by":"crossref","first-page":"4958","DOI":"10.1021\/jm025581c","volume":"45","author":"Asgian","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M607128200_bib32","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S1074-5521(00)00014-4","volume":"7","author":"Greenbaum","year":"2000","journal-title":"Chem. Biol."},{"key":"10.1074\/jbc.M607128200_bib33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nchembio707","volume":"1","author":"Kato","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"10.1074\/jbc.M607128200_bib34","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1046\/j.1471-4159.2000.0741469.x","volume":"74","author":"Bi","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M607128200_bib35","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1177\/25.12.200672","volume":"25","author":"Doty","year":"1977","journal-title":"J. Histochem. Cytochem."},{"key":"10.1074\/jbc.M607128200_bib36","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0014-5793(99)01798-6","volume":"466","author":"Caffrey","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M607128200_bib37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0166-6851(03)00194-4","volume":"131","author":"Sajid","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib38","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/S0021-9258(19)69895-9","volume":"256","author":"Green","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M607128200_bib39","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1128\/iai.64.4.1328-1334.1996","volume":"64","author":"Dalton","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M607128200_bib40","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0014-4894(78)90066-8","volume":"45","author":"Bogitsh","year":"1978","journal-title":"Exp. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib41","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s004360050310","volume":"83","author":"Caffrey","year":"1997","journal-title":"Parasitol. Res."},{"key":"10.1074\/jbc.M607128200_bib42","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2307\/3278572","volume":"59","author":"Lawrence","year":"1973","journal-title":"J. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib43","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.ijpara.2004.04.013","volume":"34","author":"Don","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib44","first-page":"291","volume":"69","author":"Ruppel","year":"1987","journal-title":"Clin. Exp. Immunol."},{"key":"10.1074\/jbc.M607128200_bib45","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0166-6851(89)90025-X","volume":"33","author":"Klinkert","year":"1989","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib46","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0014-4894(86)90025-1","volume":"62","author":"Bogitsh","year":"1986","journal-title":"Exp. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib47","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1046\/j.1432-1327.1998.2550527.x","volume":"255","author":"Hola-Jamriska","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M607128200_bib48","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0020-7519(03)00171-1","volume":"33","author":"Dalton","year":"2003","journal-title":"Int. J. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib49","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1074\/jbc.M308831200","volume":"279","author":"Collins","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M607128200_bib50","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2174\/092986650201220524115843","volume":"2","author":"Butler","year":"1995","journal-title":"Protein Pept. Lett."},{"key":"10.1074\/jbc.M607128200_bib51","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1073\/pnas.87.8.2931","volume":"87","author":"Goldberg","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M607128200_bib52","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1383-5769(97)00044-5","volume":"47","author":"Caffrey","year":"1998","journal-title":"Parasitol. Int."},{"key":"10.1074\/jbc.M607128200_bib53","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.ijpara.2005.02.002","volume":"35","author":"Wippersteg","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib54","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.molbiopara.2005.06.007","volume":"143","author":"Correnti","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib55","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1128\/AAC.42.9.2254","volume":"42","author":"Semenov","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M607128200_bib56","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1172\/JCI116262","volume":"91","author":"Rosenthal","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M607128200_bib57","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/expr.1998.4234","volume":"88","author":"Wilson","year":"1998","journal-title":"Exp. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib58","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3347\/kjp.1994.32.4.231","volume":"32","author":"Song","year":"1994","journal-title":"Korean J. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib59","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1432-1033.1995.490_2.x","volume":"233","author":"Yamakami","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M607128200_bib60","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1017\/S0031182000051738","volume":"84","author":"Maki","year":"1982","journal-title":"Parasitology"},{"key":"10.1074\/jbc.M607128200_bib61","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1017\/S0022149X00008191","volume":"60","author":"Maki","year":"1986","journal-title":"J. Helminthol."},{"key":"10.1074\/jbc.M607128200_bib62","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0166-6851(97)00074-1","volume":"88","author":"Longbottom","year":"1997","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib63","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0166-6851(90)90143-A","volume":"43","author":"Pratt","year":"1990","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M607128200_bib64","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1128\/IAI.74.3.1989-1993.2006","volume":"74","author":"Yatsuda","year":"2006","journal-title":"Infect. Immun."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819337986?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819337986?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M607128200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T03:16:49Z","timestamp":1683602209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819337986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":64,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0021925819337986"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m607128200","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1053787.505718","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}