{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:35:36Z","timestamp":1788212136999,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"49","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":5051,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1074\/jbc.m608858200","type":"journal-article","created":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T02:47:58Z","timestamp":1160534878000},"page":"38052-38060","source":"Crossref","is-referenced-by-count":6,"title":["Regulation of Catalysis by the Smallpox Virus Topoisomerase"],"prefix":"10.1016","volume":"281","author":[{"given":"Young","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Minkah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory D.","family":"Van Duyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic D.","family":"Bushman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M608858200_bib1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1099\/vir.0.19565-0","volume":"85","author":"Gubser","year":"2004","journal-title":"J. Gen. Virol."},{"key":"10.1074\/jbc.M608858200_bib2","doi-asserted-by":"crossref","first-page":"7590","DOI":"10.1128\/JVI.77.13.7590-7600.2003","volume":"77","author":"Upton","year":"2003","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M608858200_bib3","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1021\/bi962880t","volume":"36","author":"Stivers","year":"1997","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M608858200_bib4","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nature03395","volume":"434","author":"Koster","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M608858200_bib5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev.biochem.70.1.369","volume":"70","author":"Champoux","year":"2001","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M608858200_bib6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0167-4781(98)00144-4","volume":"1400","author":"Shuman","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M608858200_bib7","doi-asserted-by":"crossref","first-page":"11178","DOI":"10.1073\/pnas.0403600101","volume":"101","author":"Harrison","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M608858200_bib11","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1124\/mol.105.019067","volume":"69","author":"Bond","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M608858200_bib12","doi-asserted-by":"crossref","first-page":"17826","DOI":"10.1016\/S0021-9258(18)38238-3","volume":"265","author":"Shuman","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M608858200_bib14","doi-asserted-by":"crossref","first-page":"9160","DOI":"10.1074\/jbc.274.14.9160","volume":"274","author":"Hwang","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M608858200_bib15","doi-asserted-by":"crossref","first-page":"11476","DOI":"10.1021\/bi050796k","volume":"44","author":"Nagarajan","year":"2005","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M608858200_bib16","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/nar\/26.2.490","volume":"26","author":"Wittschieben","year":"1998","journal-title":"Nuc. Acids Res."},{"key":"10.1074\/jbc.M608858200_bib17","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S1097-2765(00)80268-3","volume":"5","author":"Krogh","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M608858200_bib18","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1093\/nar\/25.15.3001","volume":"25","author":"Wittschieben","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M608858200_bib20","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1074\/jbc.272.7.3891","volume":"272","author":"Petersen","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M608858200_bib21","doi-asserted-by":"crossref","first-page":"36091","DOI":"10.1074\/jbc.M102609200","volume":"276","author":"Krogh","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M608858200_bib22","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.molcel.2006.06.015","volume":"23","author":"Perry","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M608858200_bib23","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0092-8674(00)81411-7","volume":"92","author":"Cheng","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M608858200_bib25","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0969-2126(94)00077-8","volume":"2","author":"Sharma","year":"1994","journal-title":"Structure"},{"key":"10.1074\/jbc.M608858200_bib26","doi-asserted-by":"crossref","first-page":"31731","DOI":"10.1016\/S0021-9258(18)31757-5","volume":"269","author":"Sekiguchi","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M608858200_bib27","doi-asserted-by":"crossref","first-page":"5775","DOI":"10.1021\/bi060133i","volume":"45","author":"Nagarajan","year":"2006","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M608858200_bib28","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jmb.2006.01.022","volume":"357","author":"Davies","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M608858200_bib29","doi-asserted-by":"crossref","first-page":"9793","DOI":"10.1073\/pnas.86.24.9793","volume":"86","author":"Shuman","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M608858200_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1021\/bi00167a043","volume":"33","author":"Stivers","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M608858200_bib31","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1002\/j.1460-2075.1996.tb00711.x","volume":"15","author":"Sekiguchi","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M608858200_bib32","doi-asserted-by":"crossref","first-page":"29978","DOI":"10.1016\/S0021-9258(18)43977-4","volume":"269","author":"Wittschieben","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M608858200_bib33","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1074\/jbc.C100681200","volume":"277","author":"Krogh","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M608858200_bib8","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1124\/mol.55.6.1049","volume":"55","author":"Hwang","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M608858200_bib9","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1093\/nar\/28.24.4884","volume":"28","author":"Hwang","year":"2000","journal-title":"Nuc. Acids Res."},{"key":"10.1074\/jbc.M608858200_bib10","series-title":"DNA Replication","author":"Kornberg","year":"1991"},{"key":"10.1074\/jbc.M608858200_bib13","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1128\/JVI.72.4.3401-3406.1998","volume":"72","author":"Hwang","year":"1998","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M608858200_bib19","doi-asserted-by":"crossref","first-page":"8263","DOI":"10.1074\/jbc.272.13.8263","volume":"272","author":"Cheng","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M608858200_bib24","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1006\/viro.1999.9920","volume":"262","author":"Hwang","year":"1999","journal-title":"Virology"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820719800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820719800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M608858200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T06:22:47Z","timestamp":1625811767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820719800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":33,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0021925820719800"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m608858200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}