{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:28:33Z","timestamp":1791959313956,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":4995,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1074\/jbc.m610383200","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T02:52:48Z","timestamp":1164768768000},"page":"3165-3172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["The Crystal Structure and Mutational Binding Analysis of the Extracellular Domain of the Platelet-activating Receptor CLEC-2"],"prefix":"10.1016","volume":"282","author":[{"given":"Aleksandra A.","family":"Watson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Harlos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Eble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"O'Callaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M610383200_bib1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1182\/blood-2005-05-1994","volume":"107","author":"Suzuki-Inoue","year":"2006","journal-title":"Blood"},{"key":"10.1074\/jbc.M610383200_bib2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M","volume":"30","author":"Colonna","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1074\/jbc.M610383200_bib3","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1002\/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9","volume":"31","author":"Sobanov","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"10.1074\/jbc.M610383200_bib4","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1006\/bbrc.1998.8516","volume":"245","author":"Shin","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"Suppl. 1","key":"10.1074\/jbc.M610383200_bib5","first-page":"1","volume":"30","year":"1999","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"10.1074\/jbc.M610383200_bib6","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1128\/JVI.00136-06","volume":"80","author":"Chaipan","year":"2006","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610383200_bib7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1074-7613(01)00187-X","volume":"15","author":"O'Callaghan","year":"2001","journal-title":"Immunity"},{"key":"10.1074\/jbc.M610383200_bib8","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1107\/S1744309105037991","volume":"61","author":"Watson","year":"2005","journal-title":"Acta Crystallogr. Sect F Struct. Biol. Cryst. Commun."},{"key":"10.1074\/jbc.M610383200_bib9","doi-asserted-by":"crossref","first-page":"W606","DOI":"10.1093\/nar\/gkh400","volume":"32","author":"Claude","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M610383200_bib10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M610383200_bib11","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1110\/ps.0350503","volume":"12","author":"Kantardjieff","year":"2003","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M610383200_bib12","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","volume":"54","author":"Brunger","year":"1998","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M610383200_bib13","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","volume":"53","author":"Murshudov","year":"1997","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M610383200_bib14","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/8263","volume":"6","author":"Perrakis","year":"1999","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M610383200_bib15","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M610383200_bib16","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1107\/S0907444995010638","volume":"52","author":"Dodson","year":"1996","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M610383200_bib17","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0969-2126(96)00097-4","volume":"4","author":"Kleywegt","year":"1996","journal-title":"Structure"},{"key":"10.1074\/jbc.M610383200_bib18","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S1074-7613(01)00241-2","volume":"15","author":"Radaev","year":"2001","journal-title":"Immunity"},{"key":"10.1074\/jbc.M610383200_bib19","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.str.2005.03.016","volume":"13","author":"Ohki","year":"2005","journal-title":"Structure"},{"key":"10.1074\/jbc.M610383200_bib20","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/ni1006","volume":"4","author":"Dam","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1074\/jbc.M610383200_bib21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"10.1074\/jbc.M610383200_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0263-7855(90)80070-V","volume":"8","author":"Vriend","year":"1990","journal-title":"J. Mol. Graph."},{"key":"10.1074\/jbc.M610383200_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/prot.340110407","volume":"11","author":"Nicholls","year":"1991","journal-title":"Proteins: Struct. Funct. Genet."},{"key":"10.1074\/jbc.M610383200_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph"},{"key":"10.1074\/jbc.M610383200_bib25","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1107\/S0021889891004399","volume":"24","author":"Kraulis","year":"1991","journal-title":"J. Appl. Crystallogr."},{"key":"10.1074\/jbc.M610383200_bib26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S1093-3263(97)00021-1","volume":"15","author":"Esnouf","year":"1997","journal-title":"J. Mol. Graph. Model"},{"key":"10.1074\/jbc.M610383200_bib27","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1107\/S0907444994006396","volume":"50","author":"Merritt","year":"1994","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M610383200_bib28","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1107\/S0907444904019171","volume":"60","author":"Barrett","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M610383200_bib29","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1093\/nar\/gkg520","volume":"31","author":"Schwede","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M610383200_bib30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/bioinformatics\/btg371","volume":"20","author":"Comeau","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M610383200_bib31","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/prot.10626","volume":"52","author":"Zelensky","year":"2003","journal-title":"Proteins"},{"key":"10.1074\/jbc.M610383200_bib32","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/(SICI)1096-987X(199802)19:3<319::AID-JCC6>3.0.CO;2-W","volume":"19","author":"Fraczkiewicz","year":"1998","journal-title":"J. Computat. Chem."},{"key":"10.1074\/jbc.M610383200_bib33","doi-asserted-by":"crossref","first-page":"25121","DOI":"10.1074\/jbc.M103892200","volume":"276","author":"Bergmeier","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M610383200_bib34","doi-asserted-by":"crossref","first-page":"12274","DOI":"10.1074\/jbc.M009338200","volume":"276","author":"Eble","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M610383200_bib35","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1126\/science.1721241","volume":"254","author":"Weis","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.M610383200_bib36","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0969-2126(03)00055-8","volume":"11","author":"O'Callaghan","year":"2003","journal-title":"Structure"},{"key":"10.1074\/jbc.M610383200_bib37","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0969-2126(03)00047-9","volume":"11","author":"McFarland","year":"2003","journal-title":"Structure"},{"key":"10.1074\/jbc.M610383200_bib38","doi-asserted-by":"crossref","first-page":"15458","DOI":"10.1074\/jbc.273.25.15458","volume":"273","author":"McGaughey","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M610383200_bib39","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1097-2765(04)00080-2","volume":"13","author":"Teriete","year":"2004","journal-title":"Mol Cell"},{"key":"10.1074\/jbc.M610383200_bib40","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S1074-7613(03)00320-0","volume":"19","author":"McFarland","year":"2003","journal-title":"Immunity"},{"key":"10.1074\/jbc.M610383200_bib41","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.4049\/jimmunol.169.11.6279","volume":"169","author":"Radaev","year":"2002","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M610383200_bib42","doi-asserted-by":"crossref","first-page":"17299","DOI":"10.1074\/jbc.273.28.17299","volume":"273","author":"Ji","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M610383200_bib43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0014-4827(02)00098-8","volume":"284","author":"Jorissen","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.M610383200_bib44","doi-asserted-by":"crossref","first-page":"14779","DOI":"10.1021\/bi0018180","volume":"39","author":"Natarajan","year":"2000","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M610383200_bib45","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1074\/jbc.M006191200","volume":"276","author":"Suzuki-Inoue","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M610383200_bib46","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1128\/IAI.72.7.4159-4171.2004","volume":"72","author":"Adachi","year":"2004","journal-title":"Infect. Immun."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818384011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818384011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M610383200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T23:07:16Z","timestamp":1640992036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818384011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0021925818384011"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m610383200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Crystal Structure and Mutational Binding Analysis of the Extracellular Domain of the Platelet-activating Receptor CLEC-2","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M610383200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}