{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:52:25Z","timestamp":1791042745632,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":4958,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1074\/jbc.m611318200","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T20:52:04Z","timestamp":1172868724000},"page":"12883-12892","source":"Crossref","is-referenced-by-count":104,"title":["Functional Characterization of cis and trans Activity of the Flavivirus NS2B-NS3 Protease"],"prefix":"10.1016","volume":"282","author":[{"given":"Aloke K.","family":"Bera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M611318200_bib1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev.micro.56.012302.160654","volume":"56","author":"Brinton","year":"2002","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.M611318200_bib2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0065-3233(03)01010-6","volume":"64","author":"Kuhn","year":"2003","journal-title":"Adv. Protein Chem."},{"key":"10.1074\/jbc.M611318200_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrmicro1067","volume":"3","author":"Mukhopadhyay","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1074\/jbc.M611318200_bib4","doi-asserted-by":"crossref","first-page":"8898","DOI":"10.1073\/pnas.87.22.8898","volume":"87","author":"Chambers","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M611318200_bib5","doi-asserted-by":"crossref","first-page":"4364","DOI":"10.1128\/JVI.64.9.4364-4374.1990","volume":"64","author":"Preugschat","year":"1990","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M611318200_bib6","doi-asserted-by":"crossref","first-page":"6042","DOI":"10.1128\/JVI.65.11.6042-6050.1991","volume":"65","author":"Chambers","year":"1991","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M611318200_bib7","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1128\/JVI.65.5.2467-2475.1991","volume":"65","author":"Falgout","year":"1991","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M611318200_bib8","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1128\/JVI.67.4.2034-2042.1993","volume":"67","author":"Falgout","year":"1993","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M611318200_bib9","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1128\/JVI.67.4.2327-2335.1993","volume":"67","author":"Lin","year":"1993","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M611318200_bib10","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1006\/viro.1993.1198","volume":"193","author":"Arias","year":"1993","journal-title":"Virology"},{"key":"10.1074\/jbc.M611318200_bib11","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1006\/viro.1994.1103","volume":"199","author":"Nestorowicz","year":"1994","journal-title":"Virology"},{"key":"10.1074\/jbc.M611318200_bib12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1099\/0022-1317-78-2-337","volume":"78","author":"Teo","year":"1997","journal-title":"J. Gen. Virol."},{"key":"10.1074\/jbc.M611318200_bib13","doi-asserted-by":"crossref","first-page":"9963","DOI":"10.1074\/jbc.275.14.9963","volume":"275","author":"Yusof","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M611318200_bib14","first-page":"206","volume":"35","author":"Khumthong","year":"2002","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1074\/jbc.M611318200_bib15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bmc.2004.09.036","volume":"13","author":"Ganesh","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1074\/jbc.M611318200_bib16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/BJ20051767","volume":"397","author":"Niyomrattanakit","year":"2006","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M611318200_bib17","doi-asserted-by":"crossref","first-page":"45762","DOI":"10.1074\/jbc.M107360200","volume":"276","author":"Leung","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M611318200_bib18","doi-asserted-by":"crossref","first-page":"48535","DOI":"10.1074\/jbc.M406810200","volume":"279","author":"Nall","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M611318200_bib19","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1074\/jbc.M409931200","volume":"280","author":"Chappell","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M611318200_bib20","doi-asserted-by":"crossref","first-page":"28766","DOI":"10.1074\/jbc.M500588200","volume":"280","author":"Li","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M611318200_bib21","doi-asserted-by":"crossref","first-page":"38448","DOI":"10.1074\/jbc.M607641200","volume":"281","author":"Chappell","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M611318200_bib22","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1042\/BJ20051374","volume":"393","author":"Shiryaev","year":"2006","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M611318200_bib23","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1074\/jbc.274.9.5573","volume":"274","author":"Murthy","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M611318200_bib24","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nsmb1073","volume":"13","author":"Erbel","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1074\/jbc.M611318200_bib25","doi-asserted-by":"crossref","first-page":"10268","DOI":"10.1128\/JVI.79.16.10268-10277.2005","volume":"79","author":"Wu","year":"2005","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M611318200_bib26","doi-asserted-by":"crossref","first-page":"10278","DOI":"10.1128\/JVI.79.16.10278-10288.2005","volume":"79","author":"Xu","year":"2005","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M611318200_bib27","doi-asserted-by":"crossref","first-page":"8339","DOI":"10.1128\/JVI.79.13.8339-8347.2005","volume":"79","author":"Beasley","year":"2005","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M611318200_bib28","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1099\/vir.0.18860-0","volume":"84","author":"Bredenbeek","year":"2003","journal-title":"J. Gen. Virol."},{"key":"10.1074\/jbc.M611318200_bib29","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1128\/JVI.69.3.1600-1605.1995","volume":"69","author":"Chambers","year":"1995","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M611318200_bib30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0014-5793(93)80977-3","volume":"328","author":"Pugachev","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M611318200_bib31","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1006\/viro.1993.1076","volume":"192","author":"Lin","year":"1993","journal-title":"Virology"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818950647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818950647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M611318200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T21:17:53Z","timestamp":1616015873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818950647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":31,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0021925818950647"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m611318200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}