{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:41:30Z","timestamp":1790541690933,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"25","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":4953,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1074\/jbc.m701866200","type":"journal-article","created":{"date-parts":[[2007,4,24]],"date-time":"2007-04-24T12:56:15Z","timestamp":1177419375000},"page":"18028-18036","source":"Crossref","is-referenced-by-count":90,"title":["Nicotinic Acid Receptor Agonists Differentially Activate Downstream Effectors"],"prefix":"10.1016","volume":"282","author":[{"given":"Jeremy G.","family":"Richman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Kanemitsu-Parks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibragim","family":"Gaidarov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill S.","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuvia C.","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Cham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Maciejewski-Lenoir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic P.","family":"Behan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug","family":"Boatman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pricilla","family":"Ornelas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Gerard","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel D.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Semple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M701866200_bib1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1365-2796.2005.01528.x","volume":"258","author":"Carlson","year":"2005","journal-title":"J. Intern. Med."},{"key":"10.1074\/jbc.M701866200_bib2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.tips.2006.05.008","volume":"27","author":"Offermanns","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1074\/jbc.M701866200_bib3","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.0954-6820.1962.tb07203.x","volume":"172","author":"Carlson","year":"1962","journal-title":"Acta Med. Scand."},{"key":"10.1074\/jbc.M701866200_bib4","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.0954-6820.1963.tb17457.x","volume":"173","author":"Carlson","year":"1963","journal-title":"Acta Med. Scand."},{"key":"10.1074\/jbc.M701866200_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1749-6632.1965.tb34784.x","volume":"131","author":"Carlson","year":"1965","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1074\/jbc.M701866200_bib6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0368-1319(65)80080-1","volume":"20","author":"Carlson","year":"1965","journal-title":"J. Atheroscler. Res."},{"key":"10.1074\/jbc.M701866200_bib7","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1161\/01.ATV.17.10.2020","volume":"17","author":"Jin","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1074\/jbc.M701866200_bib8","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/hq1001.096624","volume":"21","author":"Sakai","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1074\/jbc.M701866200_bib9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1124\/mol.59.2.349","volume":"59","author":"Lorenzen","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M701866200_bib10","doi-asserted-by":"crossref","first-page":"9869","DOI":"10.1074\/jbc.M210695200","volume":"278","author":"Wise","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M701866200_bib11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nm824","volume":"9","author":"Tunaru","year":"2003","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M701866200_bib12","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0006-291X(03)00342-5","volume":"303","author":"Soga","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M701866200_bib13","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/jama.1975.03240160024021","volume":"231","author":"Coronary Drug Project","year":"1975","journal-title":"J. Am. Med. Assoc."},{"key":"10.1074\/jbc.M701866200_bib14","first-page":"437","volume":"5","author":"Hiatt","year":"1999","journal-title":"Am. J. Manag. Care"},{"key":"10.1074\/jbc.M701866200_bib15","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1001\/jama.1994.03510330050033","volume":"271","author":"McKenney","year":"1994","journal-title":"J. Am. Med. Assoc."},{"key":"10.1074\/jbc.M701866200_bib16","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1172\/JCI23626","volume":"115","author":"Beny\u00f3","year":"2005","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M701866200_bib17","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1124\/mol.106.030833","volume":"70","author":"Beny\u00f3","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M701866200_bib18","doi-asserted-by":"crossref","first-page":"6682","DOI":"10.1073\/pnas.0601574103","volume":"103","author":"Cheng","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M701866200_bib19","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1038\/sj.jid.5700586","volume":"126","author":"Maciejewski-Lenoir","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"10.1074\/jbc.M701866200_bib20","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1021\/jm030888c","volume":"46","author":"van Herk","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M701866200_bib21","doi-asserted-by":"crossref","first-page":"26649","DOI":"10.1074\/jbc.C500213200","volume":"280","author":"Taggart","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M701866200_bib22","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1074\/jbc.273.2.685","volume":"273","author":"Daaka","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M701866200_bib23","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0165-6147(00)89032-X","volume":"16","author":"Kenakin","year":"1995","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1074\/jbc.M701866200_bib24","doi-asserted-by":"crossref","first-page":"12471","DOI":"10.1073\/pnas.122368499","volume":"99","author":"Tan","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"suppl. 1","key":"10.1074\/jbc.M701866200_bib25","first-page":"S77","volume":"21","author":"Backstrom","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1074\/jbc.M701866200_bib26","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1124\/mol.54.1.94","volume":"54","author":"Berg","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M701866200_bib27","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1021\/jm950267m","volume":"39","author":"Roelen","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M701866200_bib28","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/sj.bjp.0701868","volume":"124","author":"van Schaick","year":"1998","journal-title":"Br. J. Pharmacol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820689050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820689050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M701866200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T06:42:46Z","timestamp":1641364966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820689050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":28,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0021925820689050"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m701866200","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1086047.539003","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}