{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:25:57Z","timestamp":1791120357582,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"36","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:00:00Z","timestamp":1601078400000},"content-version":"vor","delay-in-days":4774,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1074\/jbc.m703029200","type":"journal-article","created":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T05:42:45Z","timestamp":1183009365000},"page":"26517-26527","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":110,"title":["Loss of the Atp2c1 Secretory Pathway Ca2+-ATPase (SPCA1) in Mice Causes Golgi Stress, Apoptosis, and Midgestational Death in Homozygous Embryos and Squamous Cell Tumors in Adult Heterozygotes"],"prefix":"10.1016","volume":"282","author":[{"given":"Gbolahan W.","family":"Okunade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Azhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Andringa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Philip","family":"Sanford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Doetschman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary E.","family":"Shull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M703029200_bib1","doi-asserted-by":"crossref","first-page":"7600","DOI":"10.1021\/bi00148a023","volume":"31,","author":"Gunteski-Hamblin","year":"1992","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M703029200_bib2","doi-asserted-by":"crossref","first-page":"11608","DOI":"10.1074\/jbc.M413116200","volume":"280,","author":"Xiang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703029200_bib3","doi-asserted-by":"crossref","first-page":"22800","DOI":"10.1074\/jbc.M501026200","volume":"280,","author":"Vanoevelen","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703029200_bib4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0143416002001847","volume":"38,","author":"Wuytack","year":"2002","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M703029200_bib5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physrev.2001.81.1.21","volume":"81,","author":"Strehler","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M703029200_bib6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ceca.2005.06.032","volume":"38,","author":"Guerini","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M703029200_bib7","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.bbrc.2004.07.156","volume":"322,","author":"Prasad","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M703029200_bib8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbamcr.2004.08.018","volume":"1742,","author":"Van Baelen","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M703029200_bib9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1091\/mbc.3.6.633","volume":"3,","author":"Antebi","year":"1992","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M703029200_bib10","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1091\/mbc.9.5.1149","volume":"9,","author":"Durr","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M703029200_bib11","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0006-291X(03)00977-X","volume":"306,","author":"Van Baelen","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M703029200_bib12","doi-asserted-by":"crossref","first-page":"9467","DOI":"10.1074\/jbc.M413243200","volume":"280,","author":"Ramos-Casta\u00f1eda","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703029200_bib13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/71701","volume":"24,","author":"Hu","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M703029200_bib14","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/hmg\/9.7.1131","volume":"9,","author":"Sudbrak","year":"2000","journal-title":"Hum. Mol. Gen."},{"key":"10.1074\/jbc.M703029200_bib15","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1046\/j.1523-1747.2003.12528.x","volume":"121,","author":"Behne","year":"2003","journal-title":"J. Invest. Dermatol."},{"key":"10.1074\/jbc.M703029200_bib16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/6784","volume":"21,","author":"Sakuntabhai","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M703029200_bib17","doi-asserted-by":"crossref","first-page":"26737","DOI":"10.1074\/jbc.C100275200","volume":"276,","author":"Liu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703029200_bib18","doi-asserted-by":"crossref","first-page":"8655","DOI":"10.1158\/0008-5472.CAN-05-0026","volume":"65,","author":"Prasad","year":"2001","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M703029200_bib19","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0301-2115(01)00591-7","volume":"102,","author":"Vazquez","year":"2002","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1074\/jbc.M703029200_bib20","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1067\/mjd.2000.100542","volume":"43,","author":"Holst","year":"2000","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1074\/jbc.M703029200_bib21","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1046\/j.1365-2133.2000.03374.x","volume":"142,","author":"Cockayne","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"10.1074\/jbc.M703029200_bib22","doi-asserted-by":"crossref","first-page":"33742","DOI":"10.1074\/jbc.M404628200","volume":"279,","author":"Okunade","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703029200_bib23","doi-asserted-by":"crossref","first-page":"42369","DOI":"10.1074\/jbc.M407788200","volume":"279,","author":"Reinhardt","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703029200_bib24","author":"Kaufman","year":"1999","journal-title":"The Anatomical Basis of Mouse Development, Academic Press, Inc., San Diego"},{"key":"10.1074\/jbc.M703029200_bib25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0168-9525(00)89008-3","volume":"11,","author":"Copp","year":"1995","journal-title":"Trends Genet."},{"key":"10.1074\/jbc.M703029200_bib26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/371221a0","volume":"371,","author":"Tsai","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M703029200_bib27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/376062a0","volume":"376,","author":"Shalaby","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M703029200_bib28","doi-asserted-by":"crossref","first-page":"36991","DOI":"10.1074\/jbc.M004035200","volume":"275,","author":"Wakimoto","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703029200_bib29","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1096\/fj.00-0696fje","volume":"15,","author":"Koushik","year":"2001","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M703029200_bib30","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.1242\/dev.127.19.4179","volume":"127,","author":"Kruger","year":"2000","journal-title":"Development"},{"key":"10.1074\/jbc.M703029200_bib31","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.1242\/dev.00831","volume":"130,","author":"Huang","year":"2003","journal-title":"Development"},{"key":"10.1074\/jbc.M703029200_bib32","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1242\/dev.129.10.2507","volume":"129,","author":"Ybot-Gonzalez","year":"2002","journal-title":"Development"},{"key":"10.1074\/jbc.M703029200_bib33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/ajmg.c.30051","volume":"135,","author":"Greene","year":"2005","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1074\/jbc.M703029200_bib34","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1469-7580.2005.00476.x","volume":"207,","author":"Copp","year":"2005","journal-title":"J. Anat."},{"key":"10.1074\/jbc.M703029200_bib35","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1128\/MCB.15.3.1382","volume":"15,","author":"Lapinskas","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M703029200_bib36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.brainres.2004.06.064","volume":"1021,","author":"Hirata","year":"2004","journal-title":"Brain Res."},{"key":"10.1074\/jbc.M703029200_bib37","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0962-8924(97)01198-7","volume":"8,","author":"Varki","year":"1998","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.M703029200_bib38","doi-asserted-by":"crossref","first-page":"23601","DOI":"10.1016\/S0021-9258(19)49505-7","volume":"268,","author":"Renard-Rooney","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703029200_bib39","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ceca.2006.08.012","volume":"40,","author":"Dolman","year":"2006","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M703029200_bib40","doi-asserted-by":"crossref","first-page":"E255","DOI":"10.1038\/ncb1101-e255","volume":"3,","author":"Ferri","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M703029200_bib41","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1146\/annurev.biochem.73.011303.074134","volume":"74,","author":"Schroder","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M703029200_bib42","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0143-4160(03)00139-8","volume":"34,","author":"Paschen","year":"2003","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M703029200_bib43","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0092-8674(00)80835-1","volume":"101,","author":"Travers","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.M703029200_bib44","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bbamcr.2005.03.002","volume":"1744,","author":"Hicks","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M703029200_bib45","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/01.ATV.11.4.1007","volume":"11,","author":"Robenek","year":"1991","journal-title":"Arterioscler. Thromb."},{"key":"10.1074\/jbc.M703029200_bib46","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/72869","volume":"24,","author":"Orso","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M703029200_bib47","doi-asserted-by":"crossref","first-page":"10002","DOI":"10.1074\/jbc.C300024200","volume":"278,","author":"Zha","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703029200_bib48","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0167-4889(98)00049-4","volume":"1404,","author":"Fang","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M703029200_bib49","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1242\/jcs.01514","volume":"117,","author":"Marutani","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M703029200_bib50","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ceb.2005.06.010","volume":"17,","author":"Federovitch","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M703029200_bib51","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/35085509","volume":"412,","author":"Reimold","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M703029200_bib52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1083\/jcb.200406136","volume":"167,","author":"Sriburi","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M703029200_bib53","doi-asserted-by":"crossref","first-page":"7024","DOI":"10.1074\/jbc.M609490200","volume":"282,","author":"Sriburi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703029200_bib54","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ymben.2006.01.006","volume":"8,","author":"Tigges","year":"2006","journal-title":"Metab. Eng."},{"key":"10.1074\/jbc.M703029200_bib55","first-page":"679","author":"Haseman","year":"1999"},{"key":"10.1074\/jbc.M703029200_bib56","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1172\/JCI21791","volume":"114,","author":"Poblete-Gutierrez","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M703029200_bib57","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0968-0004(01)01908-9","volume":"26,","author":"Lee","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M703029200_bib58","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1371\/journal.pbio.0040374","volume":"4,","author":"Rutkowski","year":"2006","journal-title":"PLoS Biol."},{"key":"10.1074\/jbc.M703029200_bib59","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/sj.cdd.4401840","volume":"13,","author":"Wu","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.M703029200_bib60","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/nrc1505","volume":"4,","author":"Ma","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M703029200_bib61","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1158\/1541-7786.MCR-05-0221","volume":"3,","author":"Feldman","year":"2005","journal-title":"Mol. Cancer Res."},{"key":"10.1074\/jbc.M703029200_bib62","doi-asserted-by":"crossref","first-page":"723","DOI":"10.4161\/cbt.5.7.2967","volume":"5,","author":"Fels","year":"2006","journal-title":"Cancer Biol. Ther."},{"key":"10.1074\/jbc.M703029200_bib63","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ajmg.c.30031","volume":"131C,","author":"Foggia","year":"2004","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1074\/jbc.M703029200_bib64","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0960-9822(99)80162-6","volume":"9,","author":"Weil","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M703029200_bib65","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0006-2952(03)00497-0","volume":"66,","author":"Schwerk","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M703029200_bib66","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/sj.jid.5700008","volume":"126,","author":"Raj","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"10.1074\/jbc.M703029200_bib67","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.0906-6705.2005.00383.x","volume":"15,","author":"Chaturvedi","year":"2006","journal-title":"Exp. Dermatol."},{"key":"10.1074\/jbc.M703029200_bib68","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1001\/archderm.1973.01620170037011","volume":"107,","author":"Gottlieb","year":"1973","journal-title":"Arch. Dermatol."},{"key":"10.1074\/jbc.M703029200_bib69","doi-asserted-by":"crossref","first-page":"41175","DOI":"10.1074\/jbc.M105769200","volume":"276,","author":"Weiske","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703029200_bib70","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.0906-6705.2004.00217.x","volume":"13,","author":"Aho","year":"2004","journal-title":"Exp. Dermatol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820745758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820745758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M703029200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T22:50:18Z","timestamp":1679525418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820745758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":70,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0021925820745758"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m703029200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of the Atp2c1 Secretory Pathway Ca2+-ATPase (SPCA1) in Mice Causes Golgi Stress, Apoptosis, and Midgestational Death in Homozygous Embryos and Squamous Cell Tumors in Adult Heterozygotes","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M703029200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}