{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:07:13Z","timestamp":1791295633292,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"46","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":4724,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1074\/jbc.m703694200","type":"journal-article","created":{"date-parts":[[2007,9,12]],"date-time":"2007-09-12T03:39:50Z","timestamp":1189568390000},"page":"33295-33304","source":"Crossref","is-referenced-by-count":76,"title":["Pharmacologic Inhibition of Tpl2 Blocks Inflammatory Responses in Primary Human Monocytes, Synoviocytes, and Blood"],"prefix":"10.1016","volume":"282","author":[{"given":"J. Perry","family":"Hall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahya","family":"Kurdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Cuozzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Telliez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J.","family":"Seidl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Roger","family":"Askew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lih-Ling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M703694200_bib1","doi-asserted-by":"crossref","first-page":"23748","DOI":"10.1074\/jbc.M412837200","volume":"280","author":"Das","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703694200_bib2","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0092-8674(00)00210-5","volume":"103","author":"Dumitru","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.M703694200_bib3","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1093\/emboj\/cdf478","volume":"21","author":"Eliopoulos","year":"2002","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M703694200_bib4","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1093\/emboj\/cdg386","volume":"22","author":"Eliopoulos","year":"2003","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M703694200_bib5","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1084\/jem.20020281","volume":"196","author":"Kontoyiannis","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M703694200_bib6","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.cellsig.2005.10.016","volume":"18","author":"Rodriguez","year":"2006","journal-title":"Cell Signal."},{"key":"10.1074\/jbc.M703694200_bib7","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1016\/j.febslet.2006.06.004","volume":"580","author":"Stafford","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M703694200_bib8","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1172\/JCI20014","volume":"114","author":"Sugimoto","year":"2004","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M703694200_bib9","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM200103223441207","volume":"344","author":"Choy","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M703694200_bib10","series-title":"Cytokine Reference: A Compendium of Cytokines and Other Mediators of Host Defense","first-page":"413","author":"Aggarwal","year":"2001"},{"key":"10.1074\/jbc.M703694200_bib11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev.immunol.19.1.163","volume":"19","author":"Feldmann","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1074\/jbc.M703694200_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.0906-6705.2004.00205.x","volume":"13","author":"Schottelius","year":"2004","journal-title":"Exp. Dermatol."},{"key":"10.1074\/jbc.M703694200_bib13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S1359-6446(05)03721-9","volume":"11","author":"Simmons","year":"2006","journal-title":"Drug Discov. Today"},{"key":"10.1074\/jbc.M703694200_bib14","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/art.509","volume":"46","author":"Doran","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1074\/jbc.M703694200_bib15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ab.2005.11.010","volume":"350","author":"Jia","year":"2006","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M703694200_bib16","doi-asserted-by":"crossref","first-page":"9755","DOI":"10.1073\/pnas.91.21.9755","volume":"91","author":"Patriotis","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Suppl. 2","key":"10.1074\/jbc.M703694200_bib17","first-page":"191","volume":"92","author":"Helm","year":"2000","journal-title":"J. Neurosurg."},{"key":"10.1074\/jbc.M703694200_bib18","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1016\/j.bmcl.2005.08.029","volume":"15","author":"Gavrin","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1074\/jbc.M703694200_bib19","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1016\/j.bmcl.2006.08.102","volume":"16","author":"Hu","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1074\/jbc.M703694200_bib20","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1021\/jm070436q","volume":"50","author":"Green","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M703694200_bib21","doi-asserted-by":"crossref","first-page":"47089","DOI":"10.1074\/jbc.M306002200","volume":"278","author":"Channavajhala","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703694200_bib22","doi-asserted-by":"crossref","first-page":"52124","DOI":"10.1074\/jbc.M306583200","volume":"278","author":"Caivano","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703694200_bib23","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1073\/pnas.90.6.2251","volume":"90","author":"Patriotis","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M703694200_bib24","doi-asserted-by":"crossref","first-page":"52117","DOI":"10.1074\/jbc.M403716200","volume":"279","author":"Luciano","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M703694200_bib25","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/art.1780391103","volume":"39","author":"Firestein","year":"1996","journal-title":"Arthritis Rheum."},{"key":"10.1074\/jbc.M703694200_bib26","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/art.1780400207","volume":"40","author":"Crofford","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1074\/jbc.M703694200_bib27","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1172\/JCI117060","volume":"93","author":"Crofford","year":"1994","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M703694200_bib28","doi-asserted-by":"crossref","first-page":"7199","DOI":"10.4049\/jimmunol.165.12.7199","volume":"165","author":"Georganas","year":"2000","journal-title":"J. Immunol."},{"issue":"Suppl. 3","key":"10.1074\/jbc.M703694200_bib29","first-page":"iii","volume":"60","author":"Close","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"10.1074\/jbc.M703694200_bib30","first-page":"2761","volume":"27","author":"Posthumus","year":"2000","journal-title":"J. Rheumatol."},{"key":"10.1074\/jbc.M703694200_bib31","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/rheumatology\/40.5.544","volume":"40","author":"Roux-Lombard","year":"2001","journal-title":"Rheumatology (Oxf.)"},{"key":"10.1074\/jbc.M703694200_bib32","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/art.1780200612","volume":"20","author":"Woolley","year":"1977","journal-title":"Arthritis Rheum."},{"key":"10.1074\/jbc.M703694200_bib33","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/ni1334","volume":"7","author":"Papoutsopoulou","year":"2006","journal-title":"Nat. Immunol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820716637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820716637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M703694200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T13:36:47Z","timestamp":1641389807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820716637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":33,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0021925820716637"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m703694200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}