{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:06:23Z","timestamp":1791266783854,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"43","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":4734,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1074\/jbc.m704273200","type":"journal-article","created":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T20:13:26Z","timestamp":1187900006000},"page":"31504-31516","source":"Crossref","is-referenced-by-count":65,"title":["Presenilin 1 Regulates Epidermal Growth Factor Receptor Turnover and Signaling in the Endosomal-Lysosomal Pathway"],"prefix":"10.1016","volume":"282","author":[{"given":"Emanuela","family":"Repetto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Sang","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M704273200_bib1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/376775a0","volume":"376","author":"Rogaev","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M704273200_bib2","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M704273200_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/jnr.20203","volume":"77","author":"Periz","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.M704273200_bib4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/377351a0","volume":"377","author":"Levitan","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M704273200_bib5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/19096","volume":"398","author":"Ye","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M704273200_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/sj.embor.7400897","volume":"8","author":"De Strooper","year":"2007","journal-title":"EMBO Rep."},{"key":"10.1074\/jbc.M704273200_bib7","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1523\/JNEUROSCI.19-11-04229.1999","volume":"19","author":"Kang","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M704273200_bib8","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0092-8674(02)00970-4","volume":"110","author":"Kang","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M704273200_bib9","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.152.4.785","volume":"152","author":"Soriano","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M704273200_bib10","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1038\/sj.emboj.7600251","volume":"23","author":"Baki","year":"2004","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M704273200_bib11","doi-asserted-by":"crossref","first-page":"31537","DOI":"10.1074\/jbc.M500833200","volume":"280","author":"Kang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M704273200_bib12","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1523\/JNEUROSCI.23-11-04499.2003","volume":"23","author":"Pigino","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M704273200_bib13","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1523\/JNEUROSCI.19-13-05360.1999","volume":"19","author":"Weihl","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M704273200_bib14","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/S0896-6273(00)80637-6","volume":"21","author":"Naruse","year":"1998","journal-title":"Neuron"},{"key":"10.1074\/jbc.M704273200_bib15","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1083\/jcb.200406060","volume":"166","author":"Esselens","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M704273200_bib16","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1083\/jcb.200403061","volume":"165","author":"Wilson","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M704273200_bib17","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1074\/jbc.M209065200","volume":"278","author":"Cai","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M704273200_bib18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/jnr.21104","volume":"85","author":"Kuzuya","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.M704273200_bib19","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1096\/fj.05-5531fje","volume":"20","author":"Zhang","year":"2006","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M704273200_bib20","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1006\/nbdi.2002.0546","volume":"11","author":"Leem","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M704273200_bib21","doi-asserted-by":"crossref","first-page":"13818","DOI":"10.1074\/jbc.274.20.13818","volume":"274","author":"Saura","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M704273200_bib22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0014-4827(03)00002-8","volume":"284","author":"Wiley","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.M704273200_bib23","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/19077","volume":"398","author":"Wolfe","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M704273200_bib24","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S1097-2765(00)80231-2","volume":"4","author":"Levkowitz","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M704273200_bib25","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.molcel.2006.02.018","volume":"21","author":"Huang","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M704273200_bib26","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1042\/bst0311178","volume":"31","author":"Dikic","year":"2003","journal-title":"Biochem. Soc. Trans."},{"key":"10.1074\/jbc.M704273200_bib27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/1097-4652(200010)185:1<47::AID-JCP4>3.0.CO;2-O","volume":"185","author":"Kil","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"10.1074\/jbc.M704273200_bib28","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0014-5793(01)02117-2","volume":"490","author":"Waterman","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M704273200_bib29","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1101\/gad.13.21.2801","volume":"13","author":"Donoviel","year":"1999","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M704273200_bib30","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0896-6273(01)00523-2","volume":"32","author":"Feng","year":"2001","journal-title":"Neuron"},{"key":"10.1074\/jbc.M704273200_bib31","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/(SICI)1097-0029(19981201)43:5<444::AID-JEMT10>3.0.CO;2-C","volume":"43","author":"Hudson","year":"1998","journal-title":"Microsc. Res. Tech."},{"key":"10.1074\/jbc.M704273200_bib32","doi-asserted-by":"crossref","first-page":"10863","DOI":"10.1073\/pnas.191284198","volume":"98","author":"Xia","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M704273200_bib33","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.2174\/092986706779026174","volume":"13","author":"Johnston","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"10.1074\/jbc.M704273200_bib34","doi-asserted-by":"crossref","first-page":"7222","DOI":"10.1158\/1078-0432.CCR-06-0627","volume":"12","author":"Rosell","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1074\/jbc.M704273200_bib35","doi-asserted-by":"crossref","first-page":"10613","DOI":"10.1073\/pnas.0703903104","volume":"104","author":"Zhang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M704273200_bib36","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1523\/JNEUROSCI.5078-05.2006","volume":"26","author":"Almeida","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M704273200_bib37","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/(SICI)1097-4652(199909)180:3<448::AID-JCP16>3.0.CO;2-8","volume":"180","author":"Burke","year":"1999","journal-title":"J. Cell. Physiol."},{"key":"10.1074\/jbc.M704273200_bib38","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1074\/jbc.274.5.3141","volume":"274","author":"Kil","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M704273200_bib39","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1385\/JMN:25:1:079","volume":"25","author":"Ghanevati","year":"2005","journal-title":"J. Mol. Neurosci."},{"key":"10.1074\/jbc.M704273200_bib40","doi-asserted-by":"crossref","first-page":"26687","DOI":"10.1074\/jbc.M304009200","volume":"278","author":"Pasternak","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M704273200_bib41","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1073\/pnas.0509822102","volume":"103","author":"Wang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M704273200_bib42","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1093\/jnen\/63.8.821","volume":"63","author":"Cataldo","year":"2004","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1074\/jbc.M704273200_bib43","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/jnr.10753","volume":"74","author":"Uemura","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.M704273200_bib44","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cell.2006.07.037","volume":"127","author":"Sardi","year":"2006","journal-title":"Cell"},{"key":"10.1074\/jbc.M704273200_bib45","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1083\/jcb.127.5.1375","volume":"127","author":"Hoschuetzky","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M704273200_bib46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/sj.onc.1201160","volume":"15","author":"Takahashi","year":"1997","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M704273200_bib47","doi-asserted-by":"crossref","first-page":"11221","DOI":"10.1074\/jbc.M611871200","volume":"282","author":"Fang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M704273200_bib48","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1053\/j.gastro.2005.04.013","volume":"129","author":"Tan","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M704273200_bib49","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/(SICI)1097-4547(19980915)53:6<697::AID-JNR8>3.0.CO;2-0","volume":"53","author":"Kornblum","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.M704273200_bib50","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0002-9440(10)62962-8","volume":"167","author":"Chevallier","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.M704273200_bib51","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1126\/science.1115462","volume":"310","author":"Koprivica","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M704273200_bib52","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1046\/j.1471-4159.1995.65031016.x","volume":"65","author":"Casper","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M704273200_bib53","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/jcbfm.1995.55","volume":"15","author":"Maiese","year":"1995","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1074\/jbc.M704273200_bib54","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1046\/j.1471-4159.2000.0750298.x","volume":"75","author":"Cha","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M704273200_bib55","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/00005072-198809000-00006","volume":"47","author":"Birecree","year":"1988","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1074\/jbc.M704273200_bib56","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1474-4422(04)00707-0","volume":"3","author":"Zhu","year":"2004","journal-title":"Lancet Neurol."},{"key":"10.1074\/jbc.M704273200_bib57","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.bbadis.2006.10.002","volume":"1772","author":"Yang","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M704273200_bib58","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1523\/JNEUROSCI.3707-05.2006","volume":"26","author":"Yang","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M704273200_bib59","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/0896-6273(92)90247-B","volume":"9","author":"Feddersen","year":"1992","journal-title":"Neuron"},{"key":"10.1074\/jbc.M704273200_bib60","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1523\/JNEUROSCI.0186-07.2007","volume":"27","author":"Park","year":"2007","journal-title":"J. Neurosci."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820686768?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820686768?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M704273200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T06:54:08Z","timestamp":1620543248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820686768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":60,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0021925820686768"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m704273200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}