{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:02:56Z","timestamp":1791180176853,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"41","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":4745,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1074\/jbc.m704817200","type":"journal-article","created":{"date-parts":[[2007,8,16]],"date-time":"2007-08-16T20:13:21Z","timestamp":1187295201000},"page":"30014-30021","source":"Crossref","is-referenced-by-count":575,"title":["Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1\u03b1 Muscle-specific Knock-out Animals"],"prefix":"10.1016","volume":"282","author":[{"given":"Christoph","family":"Handschin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenfen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Maratos-Flier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan K.","family":"LeBrasseur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"Spiegelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M704817200_bib1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0092-8674(00)80880-6","volume":"101","author":"Olson","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.M704817200_bib2","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1152\/jappl.2001.90.3.1137","volume":"90","author":"Hood","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1074\/jbc.M704817200_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.biochem.75.103004.142622","volume":"75","author":"Bassel-Duby","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M704817200_bib4","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1210\/er.2006-0037","volume":"27","author":"Handschin","year":"2006","journal-title":"Endocr. Rev."},{"key":"10.1074\/jbc.M704817200_bib5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2005.05.004","volume":"1","author":"Lin","year":"2005","journal-title":"Cell Metab."},{"key":"10.1074\/jbc.M704817200_bib6","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nature00904","volume":"418","author":"Lin","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M704817200_bib7","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1073\/pnas.0337639100","volume":"100","author":"Czubryt","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M704817200_bib8","doi-asserted-by":"crossref","first-page":"7111","DOI":"10.1073\/pnas.1232352100","volume":"100","author":"Handschin","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M704817200_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","volume":"98","author":"Wu","year":"1999","journal-title":"Cell"},{"key":"10.1074\/jbc.M704817200_bib10","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.1073\/pnas.0401401101","volume":"101","author":"Mootha","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M704817200_bib11","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.1073\/pnas.0308686101","volume":"101","author":"Schreiber","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M704817200_bib12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ddstr.2005.05.001","volume":"2","author":"Handschin","year":"2005","journal-title":"Drug Discov. Today Ther. Strateg."},{"key":"10.1074\/jbc.M704817200_bib13","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1128\/MCB.25.4.1354-1366.2005","volume":"25","author":"Gleyzer","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M704817200_bib14","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1101\/gad.1525107","volume":"21","author":"Handschin","year":"2007","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M704817200_bib15","doi-asserted-by":"crossref","first-page":"16260","DOI":"10.1073\/pnas.0607795103","volume":"103","author":"Sandri","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M704817200_bib16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2004.09.013","volume":"119","author":"Lin","year":"2004","journal-title":"Cell"},{"key":"10.1074\/jbc.M704817200_bib17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cmet.2005.03.002","volume":"1","author":"Arany","year":"2005","journal-title":"Cell Metab."},{"key":"10.1074\/jbc.M704817200_bib18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature05767","volume":"447","author":"Liu","year":"2007","journal-title":"Nature"},{"key":"10.1074\/jbc.M704817200_bib19","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cell.2005.06.040","volume":"122","author":"Handschin","year":"2005","journal-title":"Cell"},{"key":"10.1074\/jbc.M704817200_bib20","doi-asserted-by":"crossref","first-page":"C1342","DOI":"10.1152\/ajpcell.00247.2004","volume":"287","author":"Waters","year":"2004","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M704817200_bib21","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1371\/journal.pbio.0030101","volume":"3","author":"Leone","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1074\/jbc.M704817200_bib22","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.2337\/diabetes.52.12.2874","volume":"52","author":"Russell","year":"2003","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M704817200_bib23","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0092-8674(00)00066-0","volume":"102","author":"Seale","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.M704817200_bib24","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1083\/jcb.200608122","volume":"177","author":"Olguin","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M704817200_bib25","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/ncprheum0140","volume":"2","author":"Dalakas","year":"2006","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"10.1074\/jbc.M704817200_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1023\/A:1006868130002","volume":"183","author":"Kuznetsov","year":"1998","journal-title":"Mol. Cell. Biochem."},{"key":"10.1074\/jbc.M704817200_bib27","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1096\/fj.04-1980com","volume":"19","author":"Timmons","year":"2005","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M704817200_bib28","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2006.09.024","volume":"127","author":"St.-Pierre","year":"2006","journal-title":"Cell"},{"key":"10.1074\/jbc.M704817200_bib29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-510X(98)00258-5","volume":"161","author":"Disatnik","year":"1998","journal-title":"J. Neurol. Sci."},{"key":"10.1074\/jbc.M704817200_bib30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/08916930600622256","volume":"39","author":"Salomonsson","year":"2006","journal-title":"Autoimmunity"},{"key":"10.1074\/jbc.M704817200_bib31","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s11926-996-0024-4","volume":"8","author":"Grundtman","year":"2006","journal-title":"Curr. Rheumatol. Rep."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820717606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820717606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M704817200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T22:24:06Z","timestamp":1639693446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820717606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":31,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0021925820717606"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m704817200","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1089519.544772","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}