{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:56:34Z","timestamp":1790312194271,"version":"4.1.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"47","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":4708,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1074\/jbc.m705283200","type":"journal-article","created":{"date-parts":[[2007,9,25]],"date-time":"2007-09-25T00:34:41Z","timestamp":1190680481000},"page":"34555-34567","source":"Crossref","is-referenced-by-count":70,"title":["Conformation-specific Binding of \u03b1-Synuclein to Novel Protein Partners Detected by Phage Display and NMR Spectroscopy"],"prefix":"10.1016","volume":"282","author":[{"given":"Wendy S.","family":"Woods","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Boettcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghua H.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn D.","family":"Kloepper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L.","family":"Hartman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Ladror","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad M.","family":"Rienstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia M.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M705283200_bib1","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M705283200_bib2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng0298-106","volume":"18","author":"Kruger","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M705283200_bib3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/ana.10795","volume":"55","author":"Zarranz","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M705283200_bib4","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0140-6736(04)17104-3","volume":"364","author":"Ibanez","year":"2004","journal-title":"Lancet"},{"key":"10.1074\/jbc.M705283200_bib5","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0140-6736(04)17103-1","volume":"364","author":"Chartier-Harlin","year":"2004","journal-title":"Lancet"},{"key":"10.1074\/jbc.M705283200_bib6","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M705283200_bib7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1001\/archneur.58.2.186","volume":"58","author":"Galvin","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1074\/jbc.M705283200_bib8","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1523\/JNEUROSCI.08-08-02804.1988","volume":"8","author":"Maroteaux","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M705283200_bib9","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1073\/pnas.90.23.11282","volume":"90","author":"Ueda","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M705283200_bib10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0896-6273(95)90040-3","volume":"15","author":"George","year":"1995","journal-title":"Neuron"},{"key":"10.1074\/jbc.M705283200_bib11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0896-6273(00)80886-7","volume":"25","author":"Abeliovich","year":"2000","journal-title":"Neuron"},{"key":"10.1074\/jbc.M705283200_bib12","doi-asserted-by":"crossref","first-page":"8797","DOI":"10.1523\/JNEUROSCI.22-20-08797.2002","volume":"22","author":"Cabin","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M705283200_bib13","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1074\/jbc.273.16.9443","volume":"273","author":"Davidson","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M705283200_bib14","doi-asserted-by":"crossref","first-page":"34393","DOI":"10.1074\/jbc.M004851200","volume":"275","author":"Perrin","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M705283200_bib15","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1006\/jmbi.2001.4538","volume":"307","author":"Eliezer","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M705283200_bib16","doi-asserted-by":"crossref","first-page":"8331","DOI":"10.1073\/pnas.0400553101","volume":"101","author":"Jao","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M705283200_bib17","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1021\/bi00631a035","volume":"16","author":"Barenholz","year":"1977","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M705283200_bib18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pep.2006.02.009","volume":"48","author":"Kloepper","year":"2006","journal-title":"Protein Expression Purif."},{"key":"10.1074\/jbc.M705283200_bib19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00197809","volume":"6","author":"Delaglio","year":"1995","journal-title":"J. Biomol. NMR"},{"key":"10.1074\/jbc.M705283200_bib20","series-title":"SPARKY3 Version 3.112","author":"Goddard","year":"2005"},{"key":"10.1074\/jbc.M705283200_bib21","doi-asserted-by":"crossref","first-page":"45996","DOI":"10.1074\/jbc.M106777200","volume":"276","author":"Bussell","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M705283200_bib22","doi-asserted-by":"crossref","first-page":"15313","DOI":"10.1074\/jbc.M213128200","volume":"278","author":"Chandra","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M705283200_bib23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0169-328X(01)00257-1","volume":"95","author":"Payton","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1074\/jbc.M705283200_bib24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3233\/JAD-2004-6412","volume":"6","author":"Alim","year":"2004","journal-title":"J. Alzheimers Dis."},{"key":"10.1074\/jbc.M705283200_bib25","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1242\/jcs.02746","volume":"119","author":"Spiliotis","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M705283200_bib26","doi-asserted-by":"crossref","first-page":"24095","DOI":"10.1074\/jbc.M301352200","volume":"278","author":"Ihara","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M705283200_bib27","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1242\/jcs.02558","volume":"118","author":"Utton","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M705283200_bib28","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1385\/JMN:18:3:229","volume":"18","author":"Elkon","year":"2002","journal-title":"J. Mol. Neurosci."},{"key":"10.1074\/jbc.M705283200_bib29","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1096\/fj.05-5126fje","volume":"20","author":"Gerard","year":"2006","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M705283200_bib30","doi-asserted-by":"crossref","first-page":"5544","DOI":"10.1523\/JNEUROSCI.0482-05.2005","volume":"25","author":"Smith","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M705283200_bib31","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nn1443","volume":"8","author":"Chen","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M705283200_bib32","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.1073\/pnas.89.14.6629","volume":"89","author":"Virsolvy-Vergine","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M705283200_bib33","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0304-3940(01)02025-0","volume":"310","author":"Kim","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1074\/jbc.M705283200_bib34","first-page":"1","volume":"61","author":"Kim","year":"2001","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1074\/jbc.M705283200_bib35","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0022-2836(03)00520-5","volume":"329","author":"Bussell","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M705283200_bib36","doi-asserted-by":"crossref","first-page":"9595","DOI":"10.1074\/jbc.M411805200","volume":"280","author":"Ulmer","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M705283200_bib37","author":"Boettcher","year":"2007","journal-title":"Biomol. NMR Assign."},{"key":"10.1074\/jbc.M705283200_bib38","doi-asserted-by":"crossref","first-page":"13293","DOI":"10.1021\/jp9606117","volume":"100","author":"Palmer","year":"1996","journal-title":"J. Phys. Chem."},{"key":"10.1074\/jbc.M705283200_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/bi011870b","volume":"41","author":"Zuiderweg","year":"2002","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M705283200_bib40","series-title":"The NCBI Hand-book","first-page":"21.1","author":"Pontius","year":"2003"},{"key":"10.1074\/jbc.M705283200_bib41","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ymgme.2003.09.013","volume":"81","author":"Thameem","year":"2004","journal-title":"Mol. Genet. Metab."},{"key":"10.1074\/jbc.M705283200_bib42","doi-asserted-by":"crossref","first-page":"11670","DOI":"10.1523\/JNEUROSCI.3321-06.2006","volume":"26","author":"Menegon","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M705283200_bib43","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1523\/JNEUROSCI.4278-04.2005","volume":"25","author":"Hilfiker","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M705283200_bib44","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/229","volume":"1","author":"Hilfiker","year":"1998","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M705283200_bib45","doi-asserted-by":"crossref","first-page":"8465","DOI":"10.1021\/bi0341152","volume":"42","author":"Goers","year":"2003","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M705283200_bib46","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1093\/hmg\/ddl243","volume":"15","author":"Kontopoulos","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M705283200_bib47","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1158\/0008-5472.CAN-03-3650","volume":"64","author":"Jiang","year":"2004","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M705283200_bib48","doi-asserted-by":"crossref","first-page":"51783","DOI":"10.1074\/jbc.M407336200","volume":"279","author":"Kweon","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M705283200_bib49","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1172\/JCI200318797","volume":"112","author":"Tieu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M705283200_bib50","doi-asserted-by":"crossref","first-page":"42655","DOI":"10.1074\/jbc.M505910200","volume":"280","author":"Ved","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M705283200_bib51","doi-asserted-by":"crossref","first-page":"18930","DOI":"10.1074\/jbc.273.30.18930","volume":"273","author":"Meyers","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M705283200_bib52","doi-asserted-by":"crossref","first-page":"C2004","DOI":"10.1152\/ajpcell.1996.271.6.C2004","volume":"271","author":"Naciff","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M705283200_bib53","doi-asserted-by":"crossref","first-page":"8387","DOI":"10.1073\/pnas.95.14.8387","volume":"95","author":"Heron","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M705283200_bib54","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1038\/sj.bjp.0704635","volume":"135","author":"Virsolvy","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1074\/jbc.M705283200_bib55","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00125-002-0794-9","volume":"45","author":"Gros","year":"2002","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.M705283200_bib56","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1046\/j.1471-4159.2003.02094.x","volume":"87","author":"Dou","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M705283200_bib57","doi-asserted-by":"crossref","first-page":"43179","DOI":"10.1074\/jbc.M507624200","volume":"280","author":"Ulmer","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M705283200_bib58","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature04711","volume":"440","author":"Nichols","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.M705283200_bib59","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/nn1570","volume":"8","author":"Liss","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M705283200_bib60","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1523\/JNEUROSCI.03-02-00302.1983","volume":"3","author":"Walaas","year":"1983","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M705283200_bib61","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1046\/j.1471-4159.2001.t01-1-00191.x","volume":"77","author":"Dulubova","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M705283200_bib62","first-page":"263","volume":"61","author":"Kim","year":"2001","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1074\/jbc.M705283200_bib63","doi-asserted-by":"crossref","first-page":"13895","DOI":"10.1021\/bi961186a","volume":"35","author":"Johnson","year":"1996","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M705283200_bib64","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.jmb.2007.01.049","volume":"367","author":"Labeikovsky","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M705283200_bib65","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1046\/j.1471-4159.2002.01024.x","volume":"82","author":"Lee","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M705283200_bib66","first-page":"916","volume":"15","author":"Lee","year":"2001","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M705283200_bib67","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/8820","volume":"22","author":"Engelender","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M705283200_bib68","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1042\/bj3230539","volume":"323","author":"Jensen","year":"1997","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M705283200_bib69","doi-asserted-by":"crossref","first-page":"12334","DOI":"10.1074\/jbc.M110414200","volume":"277","author":"Ahn","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M705283200_bib70","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1023\/A:1011214512601","volume":"19","author":"Huang","year":"2001","journal-title":"J. Biomol. NMR"},{"key":"10.1074\/jbc.M705283200_bib71","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1126\/science.281.5381.1357","volume":"281","author":"de Beer","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M705283200_bib72","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/sj.embor.7400276","volume":"5","author":"Dafforn","year":"2004","journal-title":"EMBO Rep."},{"key":"10.1074\/jbc.M705283200_bib73","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nsmb736","volume":"11","author":"Miele","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1074\/jbc.M705283200_bib74","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0166-2236(97)01213-7","volume":"21","author":"Clayton","year":"1998","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M705283200_bib75","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0022-2275(20)41536-6","volume":"33","author":"Segrest","year":"1992","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M705283200_bib76","doi-asserted-by":"crossref","first-page":"26515","DOI":"10.1074\/jbc.M003542200","volume":"275","author":"Pronin","year":"2000","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820545080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820545080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M705283200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T18:49:53Z","timestamp":1617216593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820545080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":76,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0021925820545080"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m705283200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}