{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:28:11Z","timestamp":1791120491454,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":4613,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1074\/jbc.m705774200","type":"journal-article","created":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T01:14:11Z","timestamp":1196471651000},"page":"2675-2683","source":"Crossref","is-referenced-by-count":129,"title":["c-Met Inhibitors with Novel Binding Mode Show Activity against Several Hereditary Papillary Renal Cell Carcinoma-related Mutations"],"prefix":"10.1016","volume":"283","author":[{"given":"Steven F.","family":"Bellon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Kaplan-Lefko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi","family":"Moriguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Rex","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol W.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B.","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Coxon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Seong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Tasker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa L.","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Dussault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M705774200_bib1","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nrm1261","volume":"4","author":"Birchmeier","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M705774200_bib2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.molmed.2005.04.005","volume":"11","author":"Corso","year":"2005","journal-title":"Trends Mol. Med."},{"key":"10.1074\/jbc.M705774200_bib3","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2174\/1566524043359674","volume":"4","author":"Dharmawardana","year":"2004","journal-title":"Curr. Mol. Med."},{"key":"10.1074\/jbc.M705774200_bib4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1096\/fasebj.14.2.399","volume":"14","author":"Giordano","year":"2000","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M705774200_bib5","doi-asserted-by":"crossref","first-page":"14417","DOI":"10.1073\/pnas.95.24.14417","volume":"95","author":"Jeffers","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M705774200_bib6","doi-asserted-by":"crossref","first-page":"11445","DOI":"10.1073\/pnas.94.21.11445","volume":"94","author":"Jeffers","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M705774200_bib7","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/(SICI)1097-0215(19990827)82:5<640::AID-IJC4>3.0.CO;2-6","volume":"82","author":"Olivero","year":"1999","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M705774200_bib8","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1038\/sj.onc.1202547","volume":"18","author":"Schmidt","year":"1999","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M705774200_bib9","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1158\/0008-5472.CAN-05-3329","volume":"66","author":"Burgess","year":"2006","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib10","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1073\/pnas.131200498","volume":"98","author":"Cao","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M705774200_bib11","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1158\/1078-0432.CCR-05-1793","volume":"12","author":"Kim","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib12","doi-asserted-by":"crossref","first-page":"6144","DOI":"10.1158\/1078-0432.CCR-05-1418","volume":"12","author":"Martens","year":"2006","journal-title":"Clin Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(97)01475-0","volume":"420","author":"Date","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M705774200_bib14","first-page":"4578","volume":"9","author":"Brockmann","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib15","first-page":"7518","volume":"61","author":"Tomioka","year":"2001","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ccr.2004.05.032","volume":"6","author":"Michieli","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M705774200_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ccr.2004.06.013","volume":"6","author":"Kong-Beltran","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M705774200_bib18","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1093\/jnci\/91.18.1548","volume":"91","author":"Abounader","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1074\/jbc.M705774200_bib19","first-page":"5161","volume":"9","author":"Kim","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib20","first-page":"5462","volume":"63","author":"Sattler","year":"2003","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib21","first-page":"1085","volume":"2","author":"Wang","year":"2003","journal-title":"Mol. Cancer Ther."},{"key":"10.1074\/jbc.M705774200_bib22","first-page":"7345","volume":"63","author":"Christensen","year":"2003","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1535-6108(02)00096-X","volume":"2","author":"Shah","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M705774200_bib24","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1053\/j.gastro.2004.11.020","volume":"128","author":"Debiec-Rychter","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M705774200_bib25","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1158\/1078-0432.CCR-03-0059","volume":"10","author":"Tamborini","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib26","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.1038\/sj.onc.1209639","volume":"25","author":"Tamborini","year":"2006","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M705774200_bib27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1126\/science.1099480","volume":"305","author":"Shah","year":"2004","journal-title":"Science"},{"key":"10.1074\/jbc.M705774200_bib28","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1158\/0008-5472.CAN-05-2788","volume":"66","author":"Young","year":"2006","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib29","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1158\/0008-5472.CAN-05-4187","volume":"66","author":"Tokarski","year":"2006","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib30","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1158\/1078-0432.CCR-04-2245","volume":"11","author":"Antonescu","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib31","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.ejca.2003.11.025","volume":"40","author":"Debiec-Rychter","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"10.1074\/jbc.M705774200_bib32","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1200\/JCO.2003.04.190","volume":"21","author":"Heinrich","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1074\/jbc.M705774200_bib33","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1158\/0008-5472.CAN-04-0085","volume":"64","author":"Chen","year":"2004","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib34","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.1038\/sj.onc.1207691","volume":"23","author":"Berthou","year":"2004","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M705774200_bib35","doi-asserted-by":"crossref","first-page":"8715","DOI":"10.1158\/0008-5472.CAN-05-4665","volume":"66","author":"Polverino","year":"2006","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib36","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/nsmb859","volume":"11","author":"Ohren","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1074\/jbc.M705774200_bib37","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M705774200_bib38","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0165-4608(92)90350-H","volume":"64","author":"Rege-Cambrin","year":"1992","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1074\/jbc.M705774200_bib39","doi-asserted-by":"crossref","first-page":"20811","DOI":"10.1074\/jbc.272.33.20811","volume":"272","author":"Nguyen","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M705774200_bib40","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1126\/science.275.5308.1943","volume":"275","author":"Li","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M705774200_bib41","doi-asserted-by":"crossref","first-page":"29943","DOI":"10.1016\/S0021-9258(18)43972-5","volume":"269","author":"Zhu","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M705774200_bib42","first-page":"2019","volume":"9","author":"Rodrigues","year":"1994","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M705774200_bib43","doi-asserted-by":"crossref","first-page":"16131","DOI":"10.1016\/S0021-9258(17)33982-0","volume":"269","author":"Komada","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M705774200_bib44","doi-asserted-by":"crossref","first-page":"12654","DOI":"10.1073\/pnas.1734128100","volume":"100","author":"Schiering","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M705774200_bib45","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1073\/pnas.0600048103","volume":"103","author":"Wang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M705774200_bib46","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/384484a0","volume":"384","author":"Yamaguchi","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M705774200_bib47","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ccr.2006.12.017","volume":"11","author":"Yun","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M705774200_bib48","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1158\/0008-5472.CAN-06-4443","volume":"67","author":"Zou","year":"2007","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib49","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1126\/science.289.5486.1938","volume":"289","author":"Schindler","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M705774200_bib50","first-page":"4236","volume":"62","author":"Nagar","year":"2002","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M705774200_bib51","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1021\/jm061107l","volume":"50","author":"Hodous","year":"2007","journal-title":"J. Med. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820555166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820555166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M705774200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T01:56:34Z","timestamp":1641347794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820555166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0021925820555166"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m705774200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}