{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:51:58Z","timestamp":1791593518078,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"vor","delay-in-days":4613,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1074\/jbc.m706620200","type":"journal-article","created":{"date-parts":[[2008,1,18]],"date-time":"2008-01-18T01:13:26Z","timestamp":1200618806000},"page":"7648-7656","source":"Crossref","is-referenced-by-count":85,"title":["E6-AP Promotes Misfolded Polyglutamine Proteins for Proteasomal Degradation and Suppresses Polyglutamine Protein Aggregation and Toxicity"],"prefix":"10.1016","volume":"283","author":[{"given":"Amit","family":"Mishra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Dikshit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudarshana","family":"Purkayastha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaiprakash","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Nukina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihar Ranjan","family":"Jana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M706620200_bib1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.neuro.23.1.217","volume":"23","author":"Zoghbi","year":"2000","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1074\/jbc.M706620200_bib2","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nrg1686","volume":"6","author":"Bates","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"10.1074\/jbc.M706620200_bib3","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nrg1690","volume":"6","author":"Di Prospero","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"10.1074\/jbc.M706620200_bib4","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nrg1691","volume":"6","author":"Gatchel","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"10.1074\/jbc.M706620200_bib5","first-page":"34","volume":"18","author":"Cattaneo","year":"2003","journal-title":"News Physiol. Sci."},{"key":"10.1074\/jbc.M706620200_bib6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1385\/MN:28:3:259","volume":"28","author":"Reiner","year":"2003","journal-title":"Mol. Neurobiol."},{"key":"10.1074\/jbc.M706620200_bib7","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0962-8924(00)01853-5","volume":"10","author":"Tobin","year":"2000","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.M706620200_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1073\/pnas.0237018100","volume":"100","author":"Ross","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M706620200_bib9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0891-0618(03)00029-2","volume":"26","author":"Jana","year":"2003","journal-title":"J. Chem. Neuroanat."},{"key":"10.1074\/jbc.M706620200_bib10","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0166-2236(00)01609-X","volume":"23","author":"Cha","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M706620200_bib11","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature05291","volume":"443","author":"Rubinsztein","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.M706620200_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1097-2765(04)00151-0","volume":"14","author":"Venkatraman","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M706620200_bib13","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1126\/science.292.5521.1552","volume":"292","author":"Bence","year":"2001","journal-title":"Science"},{"key":"10.1074\/jbc.M706620200_bib14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.molcel.2004.12.021","volume":"17","author":"Bennett","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M706620200_bib15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/502","volume":"19","author":"Cummings","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M706620200_bib16","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/hmg\/8.4.673","volume":"8","author":"Chai","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M706620200_bib17","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1093\/hmg\/9.13.2009","volume":"9","author":"Jana","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M706620200_bib18","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/hmg\/10.10.1049","volume":"10","author":"Jana","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M706620200_bib19","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1523\/JNEUROSCI.23-06-02203.2003","volume":"23","author":"Adachi","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M706620200_bib20","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/hmg\/11.5.515","volume":"11","author":"Bailey","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M706620200_bib21","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/hmg\/10.14.1511","volume":"10","author":"Cummings","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M706620200_bib22","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0896-6273(00)81035-1","volume":"24","author":"Cummings","year":"1999","journal-title":"Neuron"},{"key":"10.1074\/jbc.M706620200_bib23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)80623-6","volume":"101","author":"Yamamoto","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.M706620200_bib24","doi-asserted-by":"crossref","first-page":"8772","DOI":"10.1523\/JNEUROSCI.21-22-08772.2001","volume":"21","author":"Martin-Aparicio","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M706620200_bib25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1471-4159.2004.02486.x","volume":"90","author":"Urushitani","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M706620200_bib26","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/hmg\/ddh083","volume":"13","author":"Petrucelli","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M706620200_bib27","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/j.1471-4159.2005.03272.x","volume":"94","author":"Sahara","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M706620200_bib28","doi-asserted-by":"crossref","first-page":"23727","DOI":"10.1074\/jbc.M503326200","volume":"280","author":"Shin","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706620200_bib29","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1172\/JCI29715","volume":"117","author":"Dickey","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M706620200_bib30","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1093\/hmg\/ddm030","volume":"16","author":"Kumar","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M706620200_bib31","doi-asserted-by":"crossref","first-page":"11635","DOI":"10.1074\/jbc.M412042200","volume":"280","author":"Jana","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706620200_bib32","doi-asserted-by":"crossref","first-page":"26714","DOI":"10.1074\/jbc.M601603200","volume":"281","author":"Al-Ramahi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706620200_bib33","doi-asserted-by":"crossref","first-page":"9152","DOI":"10.1523\/JNEUROSCI.3001-05.2005","volume":"25","author":"Miller","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M706620200_bib34","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1523\/JNEUROSCI.1242-07.2007","volume":"27","author":"Adachi","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M706620200_bib35","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.bbrc.2007.04.018","volume":"357","author":"Dikshit","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M706620200_bib36","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0962-8924(01)02030-X","volume":"11","author":"Yewdell","year":"2001","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.M706620200_bib37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/373081a0","volume":"373","author":"Scheffner","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M706620200_bib38","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1073\/pnas.92.7.2563","volume":"92","author":"Huibregtse","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M706620200_bib39","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0092-8674(93)90384-3","volume":"75","author":"Scheffner","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M706620200_bib40","first-page":"775","volume":"13","author":"Huibregtse","year":"1993","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M706620200_bib41","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0896-6273(00)80596-6","volume":"21","author":"Jiang","year":"1998","journal-title":"Neuron"},{"key":"10.1074\/jbc.M706620200_bib42","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1097\/00001756-199908200-00001","volume":"10","author":"Wang","year":"1999","journal-title":"Neuroreport"},{"key":"10.1074\/jbc.M706620200_bib43","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1093\/hmg\/9.12.1795","volume":"9","author":"Wang","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M706620200_bib44","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1210\/me.2005-0110","volume":"20","author":"Khan","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M706620200_bib45","doi-asserted-by":"crossref","first-page":"18785","DOI":"10.1074\/jbc.274.26.18785","volume":"274","author":"Kumar","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706620200_bib46","doi-asserted-by":"crossref","first-page":"34302","DOI":"10.1074\/jbc.273.51.34302","volume":"273","author":"Kuhne","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706620200_bib47","doi-asserted-by":"crossref","first-page":"9557","DOI":"10.1073\/pnas.96.17.9557","volume":"96","author":"Oda","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M706620200_bib48","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1093\/hmg\/ddl225","volume":"15","author":"Reiter","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M706620200_bib49","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1046\/j.1432-1327.1998.2540643.x","volume":"254","author":"Nuber","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M706620200_bib50","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuron.2005.06.005","volume":"47","author":"Bae","year":"2005","journal-title":"Neuron"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820551545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820551545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M706620200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T01:39:54Z","timestamp":1641346794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820551545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0021925820551545"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m706620200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}