{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:15:39Z","timestamp":1791288939633,"version":"4.3.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":4619,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1074\/jbc.m706643200","type":"journal-article","created":{"date-parts":[[2007,12,11]],"date-time":"2007-12-11T01:34:23Z","timestamp":1197336863000},"page":"3465-3475","update-policy":"https:\/\/doi.org\/10.1074\/jbc.f110.005975","source":"Crossref","is-referenced-by-count":98,"title":["Rapid Turnover of the mTOR Complex 1 (mTORC1) Repressor REDD1 and Activation of mTORC1 Signaling following Inhibition of Protein Synthesis"],"prefix":"10.1016","volume":"283","author":[{"given":"Scot R.","family":"Kimball","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. N. Dang","family":"Do","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Kutzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"Cavener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard S.","family":"Jefferson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M706643200_bib1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ceb.2006.10.010","volume":"18","author":"Earnshaw","year":"2006","journal-title":"Curr. Opinion Cell Biol."},{"key":"10.1074\/jbc.M706643200_bib2","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.biocel.2006.02.013","volume":"38","author":"De Virgilio","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1074\/jbc.M706643200_bib3","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1101\/gad.995802","volume":"16","author":"Fingar","year":"2002","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M706643200_bib4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1023\/B:CARD.0000041245.61136.56","volume":"18","author":"Marvin","year":"2004","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1074\/jbc.M706643200_bib5","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1161\/01.CIR.0000130641.08705.45","volume":"109","author":"McMullen","year":"2004","journal-title":"Circulation"},{"key":"10.1074\/jbc.M706643200_bib6","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.0000057979.36322.88","volume":"107","author":"Shioi","year":"2003","journal-title":"Circulation"},{"key":"10.1074\/jbc.M706643200_bib7","doi-asserted-by":"crossref","first-page":"C120","DOI":"10.1152\/ajpcell.1999.276.1.C120","volume":"276","author":"Baar","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M706643200_bib8","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ncb1101-1014","volume":"3","author":"Bodine","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M706643200_bib9","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1152\/jappl.2001.90.5.1936","volume":"90","author":"Nader","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1074\/jbc.M706643200_bib10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/hep.20338","volume":"40","author":"Goggin","year":"2004","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M706643200_bib11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.molmed.2005.06.007","volume":"11","author":"Guertin","year":"2005","journal-title":"Trend Mol. Med."},{"key":"10.1074\/jbc.M706643200_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.277.5322.99","volume":"277","author":"Brunn","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M706643200_bib13","doi-asserted-by":"crossref","first-page":"7222","DOI":"10.1073\/pnas.92.16.7222","volume":"92","author":"Graves","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M706643200_bib14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2121-7-34","volume":"7","author":"Galbaugh","year":"2006","journal-title":"BMC Cell Biol."},{"issue":"Suppl. 2","key":"10.1074\/jbc.M706643200_bib15","doi-asserted-by":"crossref","first-page":"R251","DOI":"10.1093\/hmg\/ddi260","volume":"14","author":"Kwiatkowski","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M706643200_bib16","doi-asserted-by":"crossref","first-page":"C1232","DOI":"10.1152\/ajpcell.1998.275.5.C1232","volume":"275","author":"Fox","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M706643200_bib17","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cub.2005.02.053","volume":"15","author":"Long","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M706643200_bib18","doi-asserted-by":"crossref","first-page":"23433","DOI":"10.1074\/jbc.C500169200","volume":"280","author":"Long","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706643200_bib19","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/sj.onc.1209106","volume":"25","author":"Roccio","year":"2005","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M706643200_bib20","doi-asserted-by":"crossref","first-page":"18717","DOI":"10.1074\/jbc.M414499200","volume":"280","author":"Smith","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706643200_bib21","first-page":"E76","volume":"278","author":"Shah","year":"2000","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M706643200_bib22","first-page":"E1185","volume":"279","author":"Shah","year":"2000","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M706643200_bib23","doi-asserted-by":"crossref","first-page":"39128","DOI":"10.1074\/jbc.M610023200","volume":"281","author":"Wang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706643200_bib24","first-page":"E336","volume":"282","author":"Lang","year":"2002","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M706643200_bib25","doi-asserted-by":"crossref","first-page":"23977","DOI":"10.1074\/jbc.C200171200","volume":"277","author":"Bolster","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706643200_bib26","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1042\/bj20021266","volume":"372","author":"Beugnet","year":"2003","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M706643200_bib27","doi-asserted-by":"crossref","first-page":"14484","DOI":"10.1074\/jbc.273.23.14484","volume":"273","author":"Hara","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706643200_bib28","doi-asserted-by":"crossref","first-page":"12316","DOI":"10.1016\/S0021-9258(18)33716-5","volume":"257","author":"Nielsen","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706643200_bib29","doi-asserted-by":"crossref","first-page":"13825","DOI":"10.1016\/S0021-9258(18)80075-8","volume":"264","author":"Price","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706643200_bib30","first-page":"E74","volume":"279","author":"Shah","year":"2000","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M706643200_bib31","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.bbrc.2003.07.015","volume":"313","author":"Proud","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M706643200_bib32","volume":"5","author":"Jones","year":"2007","journal-title":"Nat. Rev. Molec. Cell Biol."},{"key":"10.1074\/jbc.M706643200_bib33","doi-asserted-by":"crossref","first-page":"6594","DOI":"10.1046\/j.1432-1327.2000.01753.x","volume":"267","author":"Loreni","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M706643200_bib34","first-page":"E585","volume":"282","author":"Kimball","year":"2002","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M706643200_bib35","first-page":"E637","volume":"285","author":"Kimball","year":"2003","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M706643200_bib36","doi-asserted-by":"crossref","first-page":"E1267","DOI":"10.1152\/ajpcell.00464.2005","volume":"290","author":"Palmer","year":"2006","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M706643200_bib37","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1152\/jappl.1991.70.5.2095","volume":"70","author":"MacLean","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"10.1074\/jbc.M706643200_bib38","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.1016\/S0021-9258(19)45112-0","volume":"247","author":"Hansen","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706643200_bib39","first-page":"185","author":"Hinnebusch","year":"2000"},{"key":"10.1074\/jbc.M706643200_bib40","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.1128\/MCB.22.19.6681-6688.2002","volume":"22","author":"Zhang","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M706643200_bib41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0076-6879(79)60008-3","volume":"60","author":"Safer","year":"1979","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M706643200_bib42","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1101\/gad.887201","volume":"15","author":"Gingras","year":"2001","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M706643200_bib43","doi-asserted-by":"crossref","first-page":"227S","DOI":"10.1093\/jn\/136.1.227S","volume":"136","author":"Kimball","year":"2006","journal-title":"J. Nutr."},{"key":"10.1074\/jbc.M706643200_bib44","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1126\/science.1079817","volume":"300","author":"Du","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M706643200_bib45","doi-asserted-by":"crossref","first-page":"29719","DOI":"10.1074\/jbc.M511636200","volume":"281","author":"Matsushima","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706643200_bib46","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.4161\/cc.4.11.2139","volume":"4","author":"Ellisen","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1074\/jbc.M706643200_bib47","doi-asserted-by":"crossref","first-page":"9769","DOI":"10.1074\/jbc.C400557200","volume":"280","author":"Corradetti","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706643200_bib48","doi-asserted-by":"crossref","first-page":"5834","DOI":"10.1128\/MCB.25.14.5834-5845.2005","volume":"25","author":"Sofer","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M706643200_bib49","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1101\/gad.1110003","volume":"17","author":"Inoki","year":"2003","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M706643200_bib50","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0960-9822(03)00506-2","volume":"13","author":"Tee","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M706643200_bib51","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ncb999","volume":"5","author":"Zhang","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M706643200_bib52","first-page":"E1274","volume":"291","author":"Yacoub Wasef","year":"2006","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M706643200_bib53","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1101\/gad.1256804","volume":"18","author":"Brugarolas","year":"2004","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M706643200_bib54","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1101\/gad.322704","volume":"18","author":"Reiling","year":"2004","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M706643200_bib55","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/sj.onc.1208236","volume":"24","author":"Schwarzer","year":"2004","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M706643200_bib56","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1128\/MCB.22.7.2283-2293.2002","volume":"22","author":"Shoshani","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M706643200_bib57","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1042\/BJ20050553","volume":"392","author":"Lin","year":"2005","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M706643200_bib58","doi-asserted-by":"crossref","first-page":"27053","DOI":"10.1074\/jbc.M303723200","volume":"278","author":"Wang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706643200_bib59","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1021\/bi047574r","volume":"44","author":"Lin","year":"2005","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M706643200_bib60","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1101\/gad.1199104","volume":"18","author":"Corradetti","year":"2004","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M706643200_bib61","doi-asserted-by":"crossref","first-page":"30945","DOI":"10.1074\/jbc.273.47.30945","volume":"273","author":"Kimball","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M706643200_bib63","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1161\/01.ATV.0000142366.69080.c3","volume":"24","author":"Cuaz-Perolin","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1074\/jbc.M706643200_bib62","doi-asserted-by":"crossref","first-page":"C18","DOI":"10.1152\/ajpcell.1989.256.1.C18","volume":"256","author":"Everson","year":"1989","journal-title":"Am. J. Physiol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820698118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820698118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M706643200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T12:27:22Z","timestamp":1641385642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820698118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0021925820698118"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m706643200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}