{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:00:54Z","timestamp":1762297254668},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":4677,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1074\/jbc.m707419200","type":"journal-article","created":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T00:24:06Z","timestamp":1193963046000},"page":"529-540","source":"Crossref","is-referenced-by-count":74,"title":["Matrix Metalloproteinase-activated Anthrax Lethal Toxin Demonstrates High Potency in Targeting Tumor Vasculature"],"prefix":"10.1016","volume":"283","author":[{"given":"Shihui","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke M.","family":"Currie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Molinolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard J.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahtab","family":"Moayeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Basile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall W.","family":"Alfano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Silvio","family":"Gutkind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur E.","family":"Frankel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Bugge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen H.","family":"Leppla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M707419200_bib1","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/S0041-0101(01)00165-9","volume":"39","author":"Collier","year":"2001","journal-title":"Toxicon"},{"key":"10.1074\/jbc.M707419200_bib2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.molcel.2003.08.003","volume":"12","author":"Liu","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M707419200_bib3","doi-asserted-by":"crossref","first-page":"9487","DOI":"10.1128\/MCB.24.21.9487-9497.2004","volume":"24","author":"Liu","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M707419200_bib4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1200\/JCO.2001.19.2.376","volume":"19","author":"Olsen","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"10.1074\/jbc.M707419200_bib5","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1517\/14712598.3.5.843","volume":"3","author":"Liu","year":"2003","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1074\/jbc.M707419200_bib6","series-title":"The Comprehensive Sourcebook of Bacterial Protein Toxins","first-page":"323","author":"Leppla","year":"2006"},{"key":"10.1074\/jbc.M707419200_bib7","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.280.5364.734","volume":"280","author":"Duesbery","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M707419200_bib8","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1006\/bbrc.1998.9040","volume":"248","author":"Vitale","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M707419200_bib9","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1042\/bj3520739","volume":"352","author":"Vitale","year":"2000","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M707419200_bib10","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.it.2006.07.002","volume":"27","author":"Baldari","year":"2006","journal-title":"Trends Immunol."},{"key":"10.1074\/jbc.M707419200_bib11","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1073\/pnas.052707699","volume":"99","author":"Koo","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M707419200_bib12","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nature00766","volume":"417","author":"Davies","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M707419200_bib13","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0092-8674(04)00215-6","volume":"116","author":"Wan","year":"2004","journal-title":"Cell"},{"key":"10.1074\/jbc.M707419200_bib14","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1158\/1535-7163.MCT-05-0145","volume":"4","author":"Abi-Habib","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"10.1074\/jbc.M707419200_bib15","doi-asserted-by":"crossref","first-page":"7437","DOI":"10.1158\/1078-0432.CCR-06-2019","volume":"12","author":"Abi-Habib","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1074\/jbc.M707419200_bib16","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1172\/JCI17991","volume":"112","author":"Moayeri","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M707419200_bib17","first-page":"6061","volume":"60","author":"Liu","year":"2000","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M707419200_bib18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc745","volume":"2","author":"Egeblad","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M707419200_bib19","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1462-5822.2006.00845.x","volume":"9","author":"Liu","year":"2007","journal-title":"Cell Microbiol"},{"key":"10.1074\/jbc.M707419200_bib20","doi-asserted-by":"crossref","first-page":"17976","DOI":"10.1074\/jbc.M011085200","volume":"276","author":"Liu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M707419200_bib21","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1073\/pnas.0236849100","volume":"100","author":"Liu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M707419200_bib22","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1128\/iai.63.9.3609-3620.1995","volume":"63","author":"Swanson","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M707419200_bib23","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0092-8674(00)81390-2","volume":"87","author":"Bugge","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.M707419200_bib24","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrc1951","volume":"6","author":"Shoemaker","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M707419200_bib25","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1073\/pnas.052160199","volume":"99","author":"Mogridge","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M707419200_bib26","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1074\/jbc.M210321200","volume":"278","author":"Liu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M707419200_bib27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ccr.2004.09.028","volume":"6","author":"Sparmann","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M707419200_bib28","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/nm1294","volume":"11","author":"Mizukami","year":"2005","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M707419200_bib29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ccr.2005.06.004","volume":"8","author":"Zeng","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M707419200_bib30","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1462-5822.2005.00606.x","volume":"8","author":"Batty","year":"2006","journal-title":"Cell Microbiol."},{"key":"10.1074\/jbc.M707419200_bib31","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0002-9440(10)64276-9","volume":"162","author":"Guedez","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.M707419200_bib32","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1056\/NEJM198612253152606","volume":"315","author":"Dvorak","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M707419200_bib33","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM199909023411006","volume":"341","author":"Singer","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M707419200_bib34","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nrc1503","volume":"4","author":"Sebolt-Leopold","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M707419200_bib35","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nature04304","volume":"439","author":"Solit","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.M707419200_bib36","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1056\/NEJMoa050092","volume":"353","author":"Curtin","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M707419200_bib37","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nbt1091","volume":"23","author":"Liu","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/jbc.M707419200_bib38","doi-asserted-by":"crossref","first-page":"7123","DOI":"10.1016\/S0021-9258(17)38364-3","volume":"261","author":"Friedlander","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M707419200_bib39","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/ng1724","volume":"38","author":"Boyden","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M707419200_bib40","doi-asserted-by":"crossref","first-page":"5175","DOI":"10.1128\/IAI.00719-07","volume":"75","author":"Moayeri","year":"2007","journal-title":"Infect. Immun."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820714134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820714134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M707419200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T13:28:29Z","timestamp":1641389309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820714134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0021925820714134"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m707419200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}