{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:15:00Z","timestamp":1791008100845,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"vor","delay-in-days":4613,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1074\/jbc.m708192200","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T01:13:41Z","timestamp":1197594821000},"page":"7390-7400","source":"Crossref","is-referenced-by-count":82,"title":["Histone Deacetylase Inhibition Modulates Kynurenine Pathway Activation in Yeast, Microglia, and Mice Expressing a Mutant Huntingtin Fragment"],"prefix":"10.1016","volume":"283","author":[{"given":"Flaviano","family":"Giorgini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zwilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Wacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyon","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Chun L.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine S.","family":"Cheah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Schwarcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Guidetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Muchowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M708192200_bib1","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1056\/NEJM198611133152006","volume":"315","author":"Martin","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M708192200_bib2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"The Huntington Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M708192200_bib3","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M708192200_bib4","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.3155875","volume":"227","author":"Graveland","year":"1985","journal-title":"Science"},{"key":"10.1074\/jbc.M708192200_bib5","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0896-6273(93)90127-D","volume":"11","author":"Li","year":"1993","journal-title":"Neuron"},{"key":"10.1074\/jbc.M708192200_bib6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000134106","volume":"71","author":"Buraczynska","year":"1995","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1074\/jbc.M708192200_bib7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/ng0595-104","volume":"10","author":"Trottier","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M708192200_bib8","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/00005072-199111000-00005","volume":"50","author":"Myers","year":"1991","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1074\/jbc.M708192200_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/jnen\/60.2.161","volume":"60","author":"Sapp","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1074\/jbc.M708192200_bib10","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1006\/exnr.1999.7170","volume":"159","author":"Singhrao","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1074\/jbc.M708192200_bib11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1074\/jbc.M708192200_bib12","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/glia.20526","volume":"55","author":"Simmons","year":"2007","journal-title":"Glia"},{"key":"10.1074\/jbc.M708192200_bib13","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/2510","volume":"20","author":"Reddy","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M708192200_bib14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1006\/exnr.1993.1159","volume":"123","author":"Topper","year":"1993","journal-title":"Exp. Neurol."},{"key":"10.1074\/jbc.M708192200_bib15","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1523\/JNEUROSCI.23-06-02193.2003","volume":"23","author":"Yu","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M708192200_bib16","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/glia.10261","volume":"43","author":"Ma","year":"2003","journal-title":"Glia"},{"key":"10.1074\/jbc.M708192200_bib17","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/brain\/awm044","volume":"130","author":"Tai","year":"2007","journal-title":"Brain"},{"key":"10.1074\/jbc.M708192200_bib18","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1212\/01.wnl.0000222734.56412.17","volume":"66","author":"Pavese","year":"2006","journal-title":"Neurology"},{"key":"10.1074\/jbc.M708192200_bib19","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1179\/016164105X49463a","volume":"27","author":"Streit","year":"2005","journal-title":"Neurol. Res."},{"key":"10.1074\/jbc.M708192200_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.102.034439","volume":"303","author":"Schwarcz","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M708192200_bib21","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1126\/science.6849138","volume":"219","author":"Schwarcz","year":"1983","journal-title":"Science"},{"key":"10.1074\/jbc.M708192200_bib22","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/321168a0","volume":"321","author":"Beal","year":"1986","journal-title":"Nature"},{"key":"10.1074\/jbc.M708192200_bib23","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1126\/science.2969147","volume":"241","author":"Davies","year":"1988","journal-title":"Science"},{"key":"10.1074\/jbc.M708192200_bib24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.nbd.2004.07.006","volume":"17","author":"Guidetti","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M708192200_bib25","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.nbd.2006.02.011","volume":"23","author":"Guidetti","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M708192200_bib26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0166-2236(00)01609-X","volume":"23","author":"Cha","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M708192200_bib27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0168-9525(03)00074-X","volume":"19","author":"Sugars","year":"2003","journal-title":"Trends Genet."},{"key":"10.1074\/jbc.M708192200_bib28","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/hmg\/9.9.1259","volume":"9","author":"Luthi-Carter","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M708192200_bib29","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1093\/hmg\/11.17.1927","volume":"11","author":"Luthi-Carter","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M708192200_bib30","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/hmg\/11.17.1911","volume":"11","author":"Luthi-Carter","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M708192200_bib31","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/35099568","volume":"413","author":"Steffan","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M708192200_bib32","doi-asserted-by":"crossref","first-page":"9418","DOI":"10.1523\/JNEUROSCI.23-28-09418.2003","volume":"23","author":"Ferrante","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M708192200_bib33","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1073\/pnas.0437870100","volume":"100","author":"Hockly","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M708192200_bib34","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1074\/jbc.M410210200","volume":"280","author":"Gardian","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M708192200_bib35","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1083\/jcb.200112104","volume":"157","author":"Meriin","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M708192200_bib36","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/ng1542","volume":"37","author":"Giorgini","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M708192200_bib37","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/hmg\/ddi443","volume":"15","author":"Apostol","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M708192200_bib38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/glia.20062","volume":"48","author":"Weydt","year":"2004","journal-title":"Glia"},{"key":"10.1074\/jbc.M708192200_bib39","doi-asserted-by":"crossref","first-page":"44727","DOI":"10.1074\/jbc.M308632200","volume":"278","author":"Mallory","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M708192200_bib40","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/ng907","volume":"31","author":"Kurdistani","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M708192200_bib41","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1126\/science.1090389","volume":"302","author":"Willingham","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M708192200_bib42","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1042\/bj3200595","volume":"320","author":"Heyes","year":"1996","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M708192200_bib43","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-1-4615-4709-9_18","volume":"467","author":"Guillemin","year":"1999","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1074\/jbc.M708192200_bib44","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1046\/j.1471-4159.2001.00498.x","volume":"78","author":"Guillemin","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M708192200_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00702-002-0770-z","volume":"110","author":"Kiss","year":"2003","journal-title":"J. Neural Transm."},{"key":"10.1074\/jbc.M708192200_bib46","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/ng1193-259","volume":"5","author":"Strong","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M708192200_bib47","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1098\/rstb.1999.0448","volume":"354","author":"Davies","year":"1999","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1074\/jbc.M708192200_bib48","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.M708192200_bib49","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1021\/jm970467t","volume":"40","author":"Rover","year":"1997","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M708192200_bib50","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0306-4522(92)90467-G","volume":"51","author":"Saito","year":"1992","journal-title":"Neuroscience"},{"key":"10.1074\/jbc.M708192200_bib51","doi-asserted-by":"crossref","first-page":"13708","DOI":"10.1073\/pnas.250477697","volume":"97","author":"Bernstein","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M708192200_bib52","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1074\/jbc.M204843200","volume":"278","author":"Schuettengruber","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M708192200_bib53","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0304-3940(92)90749-W","volume":"144","author":"Pearson","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1074\/jbc.M708192200_bib54","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0304-3940(00)00956-3","volume":"283","author":"Guidetti","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1074\/jbc.M708192200_bib55","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1073\/pnas.052702999","volume":"99","author":"Leoni","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M708192200_bib56","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1083\/jcb.200508072","volume":"171","author":"Shin","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M708192200_bib57","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1123511","volume":"312","author":"Boillee","year":"2006","journal-title":"Science"},{"key":"10.1074\/jbc.M708192200_bib58","doi-asserted-by":"crossref","first-page":"16021","DOI":"10.1073\/pnas.0607423103","volume":"103","author":"Beers","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M708192200_bib59","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/nn1750","volume":"9","author":"Custer","year":"2006","journal-title":"Nat. Neurosci."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820551272?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820551272?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M708192200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T14:37:20Z","timestamp":1639838240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820551272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":59,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0021925820551272"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m708192200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}