{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:25:17Z","timestamp":1791581117687,"version":"4.3.4"},"reference-count":52,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":4619,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1074\/jbc.m709141200","type":"journal-article","created":{"date-parts":[[2007,11,9]],"date-time":"2007-11-09T01:26:26Z","timestamp":1194571586000},"page":"3574-3583","update-policy":"https:\/\/doi.org\/10.1074\/jbc.f110.005975","source":"Crossref","is-referenced-by-count":67,"title":["Role of Phospholipase C\u03b3-induced Activation of Protein Kinase C\u03f5 (PKC\u03f5) and PKC\u03b2I in Epidermal Growth Factor-mediated Protection of Tight Junctions from Acetaldehyde in Caco-2 Cell Monolayers"],"prefix":"10.1016","volume":"283","author":[{"given":"Takuya","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Seth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhakrishna","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M709141200_bib1","first-page":"G467","volume":"269","author":"Anderson","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M709141200_bib2","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1083\/jcb.123.6.1777","volume":"123","author":"Furuse","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M709141200_bib3","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0962-8924(99)01578-0","volume":"9","author":"Tsukita","year":"1999","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.M709141200_bib4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1083\/jcb.142.1.117","volume":"142","author":"Martin-Padura","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M709141200_bib5","first-page":"319","volume":"96","author":"Ryeom","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M709141200_bib6","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1083\/jcb.127.6.1617","volume":"127","author":"Furuse","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M709141200_bib7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1083\/jcb.141.1.199","volume":"141","author":"Haskins","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M709141200_bib8","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1242\/dev.117.3.1135","volume":"117","author":"Fleming","year":"1993","journal-title":"Development"},{"key":"10.1074\/jbc.M709141200_bib9","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1083\/jcb.120.2.477","volume":"120","author":"Zhang","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M709141200_bib10","doi-asserted-by":"crossref","first-page":"16072","DOI":"10.1073\/pnas.92.13.6072","volume":"92","author":"Stuart","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M709141200_bib11","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0006-2952(98)00333-5","volume":"57","author":"Rao","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M709141200_bib12","first-page":"G332","volume":"279","author":"Rao","year":"2000","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M709141200_bib13","first-page":"G1280","volume":"280","author":"Atkinson","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M709141200_bib14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1042\/bj20011804","volume":"368","author":"Rao","year":"2002","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M709141200_bib15","doi-asserted-by":"crossref","first-page":"11916","DOI":"10.1074\/jbc.M211710200","volume":"278","author":"Basuroy","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M709141200_bib16","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1091\/mbc.01-08-0423","volume":"13","author":"Chen","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M709141200_bib17","doi-asserted-by":"crossref","first-page":"49239","DOI":"10.1074\/jbc.M305654200","volume":"278","author":"Sheth","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M709141200_bib18","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1083\/jcb.200206114","volume":"158","author":"Nunbhakdi-Craig","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M709141200_bib19","doi-asserted-by":"crossref","first-page":"11487","DOI":"10.1074\/jbc.M610597200","volume":"282","author":"Seth","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M709141200_bib20","doi-asserted-by":"crossref","first-page":"C794","DOI":"10.1152\/ajpcell.1997.272.3.C794","volume":"272","author":"Ries","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M709141200_bib21","doi-asserted-by":"crossref","first-page":"10629","DOI":"10.1073\/pnas.92.23.10629","volume":"92","author":"Nusrat","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M709141200_bib22","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1053\/gast.2001.27060","volume":"121","author":"Walsh","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M709141200_bib23","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1074\/jbc.M109254200","volume":"277","author":"Chen","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M709141200_bib24","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1172\/JCI29218","volume":"116","author":"Clayburgh","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M709141200_bib25","doi-asserted-by":"crossref","first-page":"5040","DOI":"10.1091\/mbc.e05-03-0193","volume":"16","author":"Utech","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M709141200_bib26","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/labinvest.3700330","volume":"85","author":"Shifflett","year":"2005","journal-title":"Lab. Invest."},{"key":"10.1074\/jbc.M709141200_bib27","first-page":"1621","volume":"26","author":"Hollander","year":"1994","journal-title":"Gut"},{"key":"10.1074\/jbc.M709141200_bib28","doi-asserted-by":"crossref","first-page":"340S","DOI":"10.1378\/chest.122.6_suppl.340S","volume":"122","author":"Matthay","year":"2002","journal-title":"Chest"},{"key":"10.1074\/jbc.M709141200_bib29","doi-asserted-by":"crossref","first-page":"F20","DOI":"10.1152\/ajpcell.00343.2005","volume":"290","author":"Lee","year":"2006","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M709141200_bib30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/alcalc\/agh057","volume":"39","author":"Poschl","year":"2004","journal-title":"Alcohol Alcohol."},{"key":"10.1074\/jbc.M709141200_bib31","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/carcin\/21.4.663","volume":"21","author":"Homann","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1074\/jbc.M709141200_bib32","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1530-0277.2000.tb02026.x","volume":"24","author":"Tillonen","year":"2000","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1074\/jbc.M709141200_bib33","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1530-0277.1996.tb01091.x","volume":"20","author":"Koivisto","year":"1996","journal-title":"Alcohl. Clin. Sxp. Res."},{"key":"10.1074\/jbc.M709141200_bib34","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1111\/j.1530-0277.1998.tb03972.x","volume":"22","author":"Rao","year":"1998","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1074\/jbc.M709141200_bib35","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/01.ALC.0000125358.92335.90","volume":"28","author":"Sheth","year":"2004","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1074\/jbc.M709141200_bib36","first-page":"G510","volume":"287","author":"Seth","year":"2004","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M709141200_bib37","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1042\/BJ20060665","volume":"402","author":"Sheth","year":"2007","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M709141200_bib38","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/0024-3205(91)90205-P","volume":"48","author":"Rao","year":"1991","journal-title":"Life Sci."},{"key":"10.1074\/jbc.M709141200_bib39","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/0016-5085(90)90464-C","volume":"99","author":"Konturek","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M709141200_bib40","doi-asserted-by":"crossref","first-page":"G1067","DOI":"10.1152\/ajpcell.1994.267.4.C1067","volume":"267","author":"Ishikawa","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M709141200_bib41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0014-2999(96)00186-0","volume":"303","author":"Rao","year":"1996","journal-title":"Eur. J. Phamacol."},{"key":"10.1074\/jbc.M709141200_bib42","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/BJ20050959","volume":"393","author":"Basuroy","year":"2006","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M709141200_bib43","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0006-291X(03)00167-0","volume":"302","author":"Kale","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M709141200_bib44","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1038\/sj.onc.1204778","volume":"20","author":"Schechtman","year":"2001","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M709141200_bib45","first-page":"101","volume":"1","author":"Wahl","year":"1989","journal-title":"Cancer Cells"},{"key":"10.1074\/jbc.M709141200_bib46","doi-asserted-by":"crossref","first-page":"35760","DOI":"10.1074\/jbc.M203134200","volume":"277","author":"Ward","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M709141200_bib47","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1124\/jpet.102.043638","volume":"304","author":"Ward","year":"2003","journal-title":"J. Pharmal. Exp. Ther."},{"key":"10.1074\/jbc.M709141200_bib48","first-page":"G412","volume":"281","author":"Banan","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M709141200_bib49","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1083\/jcb.137.6.1393","volume":"137","author":"Sakakibara","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M709141200_bib50","doi-asserted-by":"crossref","first-page":"10423","DOI":"10.1074\/jbc.M007136200","volume":"276","author":"Hirase","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M709141200_bib51","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1242\/jcs.113.18.3187","volume":"113","author":"Clarke","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M709141200_bib52","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1046\/j.1462-5822.2000.00055.x","volume":"2","author":"Simonovic","year":"2000","journal-title":"Cellular Micro."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820698222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820698222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M709141200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T12:27:22Z","timestamp":1641385642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820698222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0021925820698222"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m709141200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}