{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:31:15Z","timestamp":1787005875927,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","issue":"26","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":4516,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1074\/jbc.m800449200","type":"journal-article","created":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T20:59:09Z","timestamp":1209157149000},"page":"18048-18055","source":"Crossref","is-referenced-by-count":40,"title":["Extended Hormone Binding Site of the Human Thyroid Stimulating Hormone Receptor"],"prefix":"10.1016","volume":"283","author":[{"given":"Sandra","family":"Mueller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Kleinau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Jaeschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Paschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M800449200_bib1","first-page":"739","volume":"18","author":"Simoni","year":"1997","journal-title":"Endocr. Rev."},{"key":"10.1074\/jbc.M800449200_bib2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1152\/physrev.00031.2001","volume":"82","author":"Szkudlinski","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M800449200_bib3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1210\/edrv.21.5.0409","volume":"21","author":"Themmen","year":"2000","journal-title":"Endocr. Rev."},{"key":"10.1074\/jbc.M800449200_bib4","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1002\/j.1460-2075.1991.tb07714.x","volume":"10","author":"Braun","year":"1991","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M800449200_bib5","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1093\/emboj\/cdg260","volume":"22","author":"Smits","year":"2003","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M800449200_bib6","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1210\/me.2006-0309","volume":"21","author":"Kleinau","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M800449200_bib7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nature03206","volume":"433","author":"Fan","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M800449200_bib8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1089\/thy.2007.0034","volume":"17","author":"Sanders","year":"2007","journal-title":"Thyroid"},{"key":"10.1074\/jbc.M800449200_bib9","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/emboj\/21.4.504","volume":"21","author":"Costagliola","year":"2002","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M800449200_bib10","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1089\/105072502321085144","volume":"12","author":"Jeffreys","year":"2002","journal-title":"Thyroid"},{"key":"10.1074\/jbc.M800449200_bib11","doi-asserted-by":"crossref","first-page":"19413","DOI":"10.1016\/S0021-9258(18)55012-2","volume":"266","author":"Kosugi","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M800449200_bib12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0303-7207(98)00207-X","volume":"149","author":"Shepherd","year":"1999","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1074\/jbc.M800449200_bib13","doi-asserted-by":"crossref","first-page":"10900","DOI":"10.1016\/S0021-9258(18)82070-1","volume":"268","author":"Morris","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M800449200_bib14","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1210\/endo.134.3.8119184","volume":"134","author":"Dallas","year":"1994","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M800449200_bib15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1046\/j.1365-2265.2003.01864.x","volume":"59","author":"Johnstone","year":"2003","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1074\/jbc.M800449200_bib16","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1073\/pnas.88.3.902","volume":"88","author":"Nagayama","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M800449200_bib17","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1210\/me.2005-0521","volume":"20","author":"Bonomi","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M800449200_bib18","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nbt1096-1257","volume":"14","author":"Szkudlinski","year":"1996","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/jbc.M800449200_bib19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/1-4020-8107-3_19","volume":"122","author":"Szkudlinski","year":"2004","journal-title":"Cancer Treat. Res."},{"key":"10.1074\/jbc.M800449200_bib20","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1210\/endo.138.7.5259","volume":"138","author":"Chazenbalk","year":"1997","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M800449200_bib21","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1126\/science.2169649","volume":"249","author":"Wadsworth","year":"1990","journal-title":"Science"},{"key":"10.1074\/jbc.M800449200_bib22","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/0006-291X(89)92736-8","volume":"165","author":"Libert","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M800449200_bib23","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.1074\/jbc.273.14.7900","volume":"273","author":"Wonerow","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M800449200_bib24","doi-asserted-by":"crossref","first-page":"51590","DOI":"10.1074\/jbc.M404748200","volume":"279","author":"Kleinau","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M800449200_bib25","first-page":"1197","volume":"47","author":"Swillens","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M800449200_bib26","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1126\/science.289.5480.739","volume":"289","author":"Palczewski","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M800449200_bib27","doi-asserted-by":"crossref","first-page":"16123","DOI":"10.1073\/pnas.0608022103","volume":"103","author":"Salom","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M800449200_bib28","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.jmb.2007.03.007","volume":"372","author":"Standfuss","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M800449200_bib29","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nature06325","volume":"450","author":"Rasmussen","year":"2007","journal-title":"Nature"},{"key":"10.1074\/jbc.M800449200_bib30","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1126\/science.1150577","volume":"318","author":"Cherezov","year":"2007","journal-title":"Science"},{"key":"10.1074\/jbc.M800449200_bib31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1128\/JVI.72.1.279-285.1998","volume":"72","author":"Dragic","year":"1998","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M800449200_bib32","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1006\/viro.2001.1046","volume":"287","author":"Aarons","year":"2001","journal-title":"Virology"},{"key":"10.1074\/jbc.M800449200_bib33","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1074\/jbc.M606176200","volume":"282","author":"Kleinau","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M800449200_bib34","series-title":"AMBER 7","author":"Case","year":"2002"},{"key":"10.1074\/jbc.M800449200_bib35","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1006\/jmbi.1993.1351","volume":"231","author":"Laskowski","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M800449200_bib36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1210\/mend-5-1-29","volume":"5","author":"Russo","year":"1991","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M800449200_bib37","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1530\/eje.0.1470597","volume":"147","author":"Gromoll","year":"2002","journal-title":"Eur. J. Endocrinol."},{"key":"10.1074\/jbc.M800449200_bib38","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1210\/jc.2002-021946","volume":"88","author":"Muller","year":"2003","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1074\/jbc.M800449200_bib39","doi-asserted-by":"crossref","first-page":"21700","DOI":"10.1074\/jbc.272.35.21700","volume":"272","author":"Bundgaard","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M800449200_bib40","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1126\/science.1145373","volume":"317","author":"Huang","year":"2007","journal-title":"Science"},{"key":"10.1074\/jbc.M800449200_bib41","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/nbt0998-871","volume":"16","author":"Grossmann","year":"1998","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/jbc.M800449200_bib42","doi-asserted-by":"crossref","first-page":"27457","DOI":"10.1016\/S0021-9258(19)61530-9","volume":"275","author":"Leitolf","year":"2000","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820815543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820815543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M800449200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T14:48:05Z","timestamp":1641394085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820815543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":42,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0021925820815543"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m800449200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}