{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:59:39Z","timestamp":1791896379981,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":4488,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1074\/jbc.m800834200","type":"journal-article","created":{"date-parts":[[2008,3,27]],"date-time":"2008-03-27T00:13:27Z","timestamp":1206576807000},"page":"15845-15852","source":"Crossref","is-referenced-by-count":54,"title":["Therapeutic Gene Silencing Delivered by a Chemically Modified Small Interfering RNA against Mutant SOD1 Slows Amyotrophic Lateral Sclerosis Progression"],"prefix":"10.1016","volume":"283","author":[{"given":"Hongyan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Animesh","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huricha","family":"Baigude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-shun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghua","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xugang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq M.","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoshang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M800834200_bib1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/ncpneuro0551","volume":"3","author":"Gonzalez-Alegre","year":"2007","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"10.1074\/jbc.M800834200_bib2","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nature02872","volume":"431","author":"Mello","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M800834200_bib3","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/35078107","volume":"411","author":"Elbashir","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M800834200_bib4","doi-asserted-by":"crossref","first-page":"9742","DOI":"10.1073\/pnas.171251798","volume":"98","author":"Caplen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M800834200_bib5","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.tig.2004.08.006","volume":"20","author":"Jackson","year":"2004","journal-title":"Trends Genet."},{"key":"10.1074\/jbc.M800834200_bib6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nbt1081","volume":"23","author":"Judge","year":"2005","journal-title":"Nat. Biotech."},{"key":"10.1074\/jbc.M800834200_bib7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm1191","volume":"11","author":"Hornung","year":"2005","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M800834200_bib8","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nature04791","volume":"441","author":"Grimm","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.M800834200_bib9","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.1073\/pnas.1131959100","volume":"100","author":"Semizarov","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M800834200_bib10","first-page":"1197","volume":"12","author":"Jackson","year":"2006","journal-title":"RNA (Cold Spring Harbor)"},{"key":"10.1074\/jbc.M800834200_bib11","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nature06179","volume":"449","author":"John","year":"2007","journal-title":"Nature"},{"key":"10.1074\/jbc.M800834200_bib12","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1172\/JCI34274","volume":"117","author":"Gewirtz","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M800834200_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0070-2153(06)75003-7","volume":"75","author":"Boudreau","year":"2006","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1074\/jbc.M800834200_bib14","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.bmcl.2003.12.074","volume":"14","author":"Braasch","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1074\/jbc.M800834200_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nature05901","volume":"448","author":"Kumar","year":"2007","journal-title":"Nature"},{"key":"10.1074\/jbc.M800834200_bib16","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1093\/nar\/gnh044","volume":"32","author":"Dorn","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M800834200_bib17","doi-asserted-by":"crossref","first-page":"17204","DOI":"10.1073\/pnas.0708285104","volume":"104","author":"DiFiglia","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M800834200_bib18","first-page":"1034","volume":"9","author":"Chiu","year":"2003","journal-title":"RNA (Cold Spring Harbor)"},{"key":"10.1074\/jbc.M800834200_bib19","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nchembio839","volume":"2","author":"Bumcrot","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"10.1074\/jbc.M800834200_bib20","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/nbt1122","volume":"23","author":"Morrissey","year":"2005","journal-title":"Nat Biotech."},{"key":"10.1074\/jbc.M800834200_bib21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature03121","volume":"432","author":"Soutschek","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M800834200_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1021\/cb7000582","volume":"2","author":"Baigude","year":"2007","journal-title":"ACS Chem Biol."},{"key":"10.1074\/jbc.M800834200_bib23","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","volume":"264","author":"Gurney","year":"1994","journal-title":"Science"},{"key":"10.1074\/jbc.M800834200_bib24","first-page":"225","volume":"1","author":"Xu","year":"2000","journal-title":"Amyotroph. Lateral Scler."},{"key":"10.1074\/jbc.M800834200_bib25","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1021\/bc00030a005","volume":"5","author":"Shah","year":"1994","journal-title":"Bioconjugate Chem."},{"key":"10.1074\/jbc.M800834200_bib26","doi-asserted-by":"crossref","first-page":"39092","DOI":"10.1074\/jbc.M301749200","volume":"278","author":"Hwang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M800834200_bib27","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2144\/000112401","volume":"42","author":"Hummon","year":"2007","journal-title":"BioTechniques"},{"key":"10.1074\/jbc.M800834200_bib28","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1056\/NEJM199412223312516","volume":"331","author":"Gurney","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M800834200_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jneumeth.2003.09.015","volume":"133","author":"Wu","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"10.1074\/jbc.M800834200_bib30","first-page":"189","volume":"43","author":"Papaioannou","year":"1993","journal-title":"Lab. Anim. Sci."},{"key":"10.1074\/jbc.M800834200_bib31","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1128\/jvi.62.9.3077-3083.1988","volume":"62","author":"Flenniken","year":"1988","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M800834200_bib32","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1097-2765(02)00652-4","volume":"10","author":"Chiu","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M800834200_bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrm2085","volume":"8","author":"Rana","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M800834200_bib34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0188-4409(00)00061-8","volume":"31","author":"Rise","year":"2000","journal-title":"Arch. Med. Res."},{"key":"10.1074\/jbc.M800834200_bib35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/sj.onc.1208207","volume":"24","author":"Elchuri","year":"2005","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M800834200_bib36","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.1086071","volume":"302","author":"Clement","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M800834200_bib37","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1123511","volume":"312","author":"Boillee","year":"2006","journal-title":"Science"},{"key":"10.1074\/jbc.M800834200_bib38","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.nbd.2006.04.019","volume":"23","author":"Xia","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M800834200_bib39","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/brain\/awh704","volume":"129","author":"Jonsson","year":"2006","journal-title":"Brain"},{"key":"10.1074\/jbc.M800834200_bib40","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1172\/JCI25424","volume":"116","author":"Smith","year":"2006","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M800834200_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/108729003764097296","volume":"13","author":"Miyagishi","year":"2003","journal-title":"Antisense Nucleic Acid Drug Dev."},{"key":"10.1074\/jbc.M800834200_bib42","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1093\/nar\/gkg649","volume":"31","author":"Kretschmer-Kazemi Far","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M800834200_bib43","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0006-291X(02)02013-2","volume":"296","author":"Bertrand","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820461216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820461216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M800834200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T14:03:13Z","timestamp":1639836193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820461216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":43,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0021925820461216"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m800834200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}