{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:35:20Z","timestamp":1781051720291,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T00:00:00Z","timestamp":1600473600000},"content-version":"vor","delay-in-days":4524,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1074\/jbc.m801093200","type":"journal-article","created":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T02:28:15Z","timestamp":1207103295000},"page":"14376-14383","source":"Crossref","is-referenced-by-count":31,"title":["The Substrates of the \u03b3-Aminobutyric Acid Transporter GAT-1 Induce Structural Rearrangements around the Interface of Transmembrane Domains 1 and 6"],"prefix":"10.1016","volume":"283","author":[{"given":"Alex","family":"Rosenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baruch I.","family":"Kanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M801093200_bib1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1242\/jeb.196.1.237","volume":"196","author":"Kanner","year":"1994","journal-title":"J. Exp. Biol."},{"key":"10.1074\/jbc.M801093200_bib2","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1046\/j.1471-4159.1998.71051785.x","volume":"71","author":"Nelson","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M801093200_bib3","doi-asserted-by":"crossref","first-page":"15437","DOI":"10.1016\/S0021-9258(18)66730-4","volume":"261","author":"Radian","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib4","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.1975955","volume":"249","author":"Guastella","year":"1990","journal-title":"Science"},{"key":"10.1074\/jbc.M801093200_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1021\/bi00401a003","volume":"27","author":"Keynan","year":"1988","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M801093200_bib6","doi-asserted-by":"crossref","first-page":"22007","DOI":"10.1016\/S0021-9258(18)41626-2","volume":"267","author":"Kavanaugh","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0896-6273(93)90309-F","volume":"10","author":"Mager","year":"1993","journal-title":"Neuron"},{"key":"10.1074\/jbc.M801093200_bib8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1085\/jgp.114.3.429","volume":"114","author":"Lu","year":"1999","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.M801093200_bib9","doi-asserted-by":"crossref","first-page":"5405","DOI":"10.1523\/JNEUROSCI.16-17-05405.1996","volume":"16","author":"Mager","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M801093200_bib10","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1085\/jgp.114.3.459","volume":"114","author":"Hilgemann","year":"1999","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.M801093200_bib11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nature03978","volume":"437","author":"Yamashita","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M801093200_bib12","doi-asserted-by":"crossref","first-page":"22092","DOI":"10.1074\/jbc.M602319200","volume":"281","author":"Zhou","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib13","doi-asserted-by":"crossref","first-page":"36213","DOI":"10.1074\/jbc.M605468200","volume":"281","author":"Zhang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib14","doi-asserted-by":"crossref","first-page":"14447","DOI":"10.1074\/jbc.M609158200","volume":"282","author":"Vandenberg","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib15","doi-asserted-by":"crossref","first-page":"15528","DOI":"10.1074\/jbc.M611705200","volume":"282","author":"Dodd","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib16","doi-asserted-by":"crossref","first-page":"12703","DOI":"10.1074\/jbc.M206563200","volume":"278","author":"Androutsellis-Theotokis","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib17","doi-asserted-by":"crossref","first-page":"26444","DOI":"10.1074\/jbc.M602438200","volume":"281","author":"Quick","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib18","doi-asserted-by":"crossref","first-page":"12761","DOI":"10.1073\/pnas.0705600104","volume":"104","author":"Forrest","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M801093200_bib19","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nature06133","volume":"449","author":"Zomot","year":"2007","journal-title":"Nature"},{"key":"10.1074\/jbc.M801093200_bib20","doi-asserted-by":"crossref","first-page":"13800","DOI":"10.1074\/jbc.M311579200","volume":"279","author":"Zhou","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib21","doi-asserted-by":"crossref","first-page":"37052","DOI":"10.1074\/jbc.M305514200","volume":"278","author":"Henry","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib22","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0076-6879(87)54085-X","volume":"154","author":"Kunkel","year":"1987","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M801093200_bib23","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1016\/S0021-9258(17)42047-3","volume":"269","author":"Kleinberger-Doron","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib24","doi-asserted-by":"crossref","first-page":"8122","DOI":"10.1073\/pnas.83.21.8122","volume":"83","author":"Fuerst","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M801093200_bib25","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1021\/bi00122a011","volume":"31","author":"Keynan","year":"1992","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M801093200_bib26","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1074\/jbc.M107735200","volume":"277","author":"Brocke","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib27","doi-asserted-by":"crossref","first-page":"25512","DOI":"10.1074\/jbc.M503864200","volume":"280","author":"Zomot","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib28","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1074\/jbc.M210525200","volume":"278","author":"Kanner","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib29","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1021\/bi962256g","volume":"36","author":"Chen","year":"1997","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M801093200_bib30","doi-asserted-by":"crossref","first-page":"17699","DOI":"10.1074\/jbc.M009196200","volume":"276","author":"Roux","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib31","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1074\/jbc.272.2.1203","volume":"272","author":"Bennett","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib32","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0014-5793(98)00333-0","volume":"426","author":"Yu","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M801093200_bib33","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nature03018","volume":"431","author":"Yernool","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M801093200_bib34","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1073\/pnas.93.1.300","volume":"93","author":"Perez-Garcia","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M801093200_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3233(08)60534-3","volume":"42","author":"Glusker","year":"1991","journal-title":"Adv. Protein Chem."},{"key":"10.1074\/jbc.M801093200_bib36","doi-asserted-by":"crossref","first-page":"7392","DOI":"10.1073\/pnas.93.14.7392","volume":"93","author":"Benitah","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M801093200_bib37","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s00018-005-5512-6","volume":"63","author":"Mari","year":"2006","journal-title":"Cell Mol. Life Sci."},{"key":"10.1074\/jbc.M801093200_bib38","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1073\/pnas.97.3.1044","volume":"97","author":"Chen","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M801093200_bib39","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nature06038","volume":"448","author":"Singh","year":"2007","journal-title":"Nature"},{"key":"10.1074\/jbc.M801093200_bib40","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1126\/science.1147614","volume":"317","author":"Zhou","year":"2007","journal-title":"Science"},{"key":"10.1074\/jbc.M801093200_bib41","doi-asserted-by":"crossref","first-page":"42950","DOI":"10.1074\/jbc.M209307200","volume":"278","author":"Zomot","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M801093200_bib42","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820543044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820543044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M801093200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T02:17:28Z","timestamp":1639707448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820543044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":42,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0021925820543044"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m801093200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}