{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:26:54Z","timestamp":1783081614248,"version":"3.54.6"},"reference-count":44,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":4256,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1074\/jbc.m804812200","type":"journal-article","created":{"date-parts":[[2008,12,6]],"date-time":"2008-12-06T01:12:48Z","timestamp":1228525968000},"page":"4658-4666","source":"Crossref","is-referenced-by-count":41,"title":["Interferon-\u03b3 Targets Cancer Cells and Osteoclasts to Prevent Tumor-associated Bone Loss and Bone Metastases"],"prefix":"10.1016","volume":"284","author":[{"given":"Zhiqiang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Hurchla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongju","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge","family":"Ulu\u00e7kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Berdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Eagleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela A.","family":"Heller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree H.","family":"Floyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wessel P.","family":"Dirksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuetsu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad A.","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Rosol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine N.","family":"Weilbaecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M804812200_bib1","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nri1961","volume":"6","author":"Dunn","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1074\/jbc.M804812200_bib2","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1182\/blood-2004-01-0266","volume":"104","author":"Mitra-Kaushik","year":"2004","journal-title":"Blood."},{"key":"10.1074\/jbc.M804812200_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1359-6101(01)00038-7","volume":"13","author":"Ikeda","year":"2002","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1074\/jbc.M804812200_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/gut.49.2.251","volume":"49","author":"Detjen","year":"2001","journal-title":"Gut."},{"key":"10.1074\/jbc.M804812200_bib5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1046\/j.0019-2805.2001.01342.x","volume":"105","author":"Kakuta","year":"2002","journal-title":"Immunology."},{"key":"10.1074\/jbc.M804812200_bib6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/cncr.22038","volume":"107","author":"Tannir","year":"2006","journal-title":"Cancer."},{"key":"10.1074\/jbc.M804812200_bib7","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2353\/ajpath.2007.060834","volume":"170","author":"Teitelbaum","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.M804812200_bib8","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/35046102","volume":"408","author":"Takayanagi","year":"2000","journal-title":"Nature."},{"key":"10.1074\/jbc.M804812200_bib9","doi-asserted-by":"crossref","first-page":"R220","DOI":"10.1186\/ar1167","volume":"6","author":"De Klerck","year":"2004","journal-title":"Arthritis Res. Ther."},{"key":"10.1074\/jbc.M804812200_bib10","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1136\/ard.62.10.983","volume":"62","author":"Chu","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"10.1074\/jbc.M804812200_bib11","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.4049\/jimmunol.158.11.5507","volume":"158","author":"Vermeire","year":"1997","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M804812200_bib12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1172\/JCI30074","volume":"117","author":"Gao","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M804812200_bib13","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1056\/NEJM199506153322402","volume":"332","author":"Key","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M804812200_bib14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0008-8749(91)90052-D","volume":"137","author":"Hochman","year":"1991","journal-title":"Cell. Immunol."},{"key":"10.1074\/jbc.M804812200_bib15","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1089\/107999000414826","volume":"20","author":"Madyastha","year":"2000","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1074\/jbc.M804812200_bib16","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1073\/pnas.92.4.1057","volume":"92","author":"Grossman","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M804812200_bib17","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1182\/blood-2005-04-1730","volume":"106","author":"Gao","year":"2005","journal-title":"Blood."},{"key":"10.1074\/jbc.M804812200_bib18","doi-asserted-by":"crossref","first-page":"14221","DOI":"10.1074\/jbc.M111551200","volume":"277","author":"Tintut","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M804812200_bib19","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1182\/blood-2006-09-048686","volume":"109","author":"Hirbe","year":"2007","journal-title":"Blood."},{"key":"10.1074\/jbc.M804812200_bib20","doi-asserted-by":"crossref","first-page":"14205","DOI":"10.1073\/pnas.2234372100","volume":"100","author":"Bakewell","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M804812200_bib21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1349-7006.1990.tb02554.x","volume":"81","author":"Tanaka","year":"1990","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1074\/jbc.M804812200_bib22","doi-asserted-by":"crossref","first-page":"551","DOI":"10.2353\/ajpath.2006.050480","volume":"168","author":"Natasha","year":"2006","journal-title":"Am J. Pathol."},{"key":"10.1074\/jbc.M804812200_bib23","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1359\/JBMR.050724","volume":"20","author":"Zhao","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1074\/jbc.M804812200_bib24","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/jcb.10142","volume":"85","author":"Kim","year":"2002","journal-title":"J. Cell. Biochem."},{"key":"10.1074\/jbc.M804812200_bib25","first-page":"1133","volume":"21","author":"Detjen","year":"2002","journal-title":"Int. J. Oncol."},{"key":"10.1074\/jbc.M804812200_bib26","doi-asserted-by":"crossref","first-page":"18623","DOI":"10.1074\/jbc.273.29.18623","volume":"273","author":"Favata","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M804812200_bib27","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1006\/bbrc.2000.3577","volume":"276","author":"Fox","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M804812200_bib28","doi-asserted-by":"crossref","first-page":"R49","DOI":"10.1186\/ar612","volume":"5","author":"Huang","year":"2003","journal-title":"Arthritis Res. Ther."},{"key":"10.1074\/jbc.M804812200_bib29","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1158\/0008-5472.CAN-04-4316","volume":"65","author":"Dunn","year":"2005","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M804812200_bib30","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1038\/onc.2008.147","volume":"27","author":"Lee","year":"2008","journal-title":"Oncogene."},{"key":"10.1074\/jbc.M804812200_bib31","doi-asserted-by":"crossref","first-page":"7556","DOI":"10.1073\/pnas.95.13.7556","volume":"95","author":"Kaplan","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M804812200_bib32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1742-4690-3-22","volume":"3","author":"Tomita","year":"2006","journal-title":"Retrovirology."},{"key":"10.1074\/jbc.M804812200_bib33","doi-asserted-by":"crossref","first-page":"14062","DOI":"10.1073\/pnas.0705203104","volume":"104","author":"Hirbe","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M804812200_bib34","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrc867","volume":"2","author":"Mundy","year":"2002","journal-title":"Nat. Rev. Cancer."},{"key":"10.1074\/jbc.M804812200_bib35","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1172\/JCI112677","volume":"78","author":"Takahashi","year":"1986","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M804812200_bib36","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/BOR.0b013e32805e87e0","volume":"19","author":"Toh","year":"2007","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1074\/jbc.M804812200_bib37","doi-asserted-by":"crossref","first-page":"8226","DOI":"10.4049\/jimmunol.177.11.8226","volume":"177","author":"Zhu","year":"2006","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M804812200_bib38","doi-asserted-by":"crossref","first-page":"8844","DOI":"10.4049\/jimmunol.177.12.8844","volume":"177","author":"Wan","year":"2006","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M804812200_bib39","first-page":"859","volume":"9","author":"Cochran","year":"1989","journal-title":"Anticancer Res."},{"key":"10.1074\/jbc.M804812200_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2007.02587.x","volume":"121","author":"Kim","year":"2007","journal-title":"Immunology."},{"key":"10.1074\/jbc.M804812200_bib41","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s00262-006-0257-0","volume":"56","author":"Merchant","year":"2007","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1074\/jbc.M804812200_bib42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1074-7613(00)80085-0","volume":"11","author":"Xaus","year":"1999","journal-title":"Immunity."},{"key":"10.1074\/jbc.M804812200_bib43","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1128\/iai.65.12.5149-5156.1997","volume":"65","author":"Fenton","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M804812200_bib44","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1111\/j.1464-410X.2007.06862.x","volume":"99","author":"Weissglas","year":"2007","journal-title":"BJU Int."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820710689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820710689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M804812200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T10:27:27Z","timestamp":1684751247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820710689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0021925820710689"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m804812200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}