{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:13:55Z","timestamp":1791249235061,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":4259,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1074\/jbc.m805432200","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T20:13:11Z","timestamp":1230754391000},"page":"4897-4904","source":"Crossref","is-referenced-by-count":135,"title":["Fibroblast Growth Factor Receptor 2 Promotes Osteogenic Differentiation in Mesenchymal Cells via ERK1\/2 and Protein Kinase C Signaling"],"prefix":"10.1016","volume":"284","author":[{"given":"Hichem","family":"Miraoui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Oudina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Petite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiho","family":"Tanimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Moriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre J.","family":"Marie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M805432200_bib1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science."},{"key":"10.1074\/jbc.M805432200_bib2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1634\/stemcells.19-3-180","volume":"19","author":"Bianco","year":"2001","journal-title":"Stem Cells."},{"key":"10.1074\/jbc.M805432200_bib3","first-page":"63","volume":"10","author":"Owen","year":"2002","journal-title":"Cell Sci. Suppl."},{"key":"10.1074\/jbc.M805432200_bib4","series-title":"Principles of Bone Biology","first-page":"59","volume":"1","author":"Aubin","year":"2002"},{"key":"10.1074\/jbc.M805432200_bib5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/jcb.20777","volume":"98","author":"Gimble","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"10.1074\/jbc.M805432200_bib6","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2217\/17460751.1.4.539","volume":"1","author":"Marie","year":"2006","journal-title":"Regen. Med."},{"key":"10.1074\/jbc.M805432200_bib7","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1634\/stemcells.2007-0637","volume":"25","author":"Phinney","year":"2007","journal-title":"Stem Cells."},{"key":"10.1074\/jbc.M805432200_bib8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1006\/scdb.2000.0188","volume":"11","author":"Karsenty","year":"2000","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1074\/jbc.M805432200_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1010011209064","volume":"2","author":"Aubin","year":"2001","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1074\/jbc.M805432200_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/CritRevEukaryotGeneExpr.v14.i12.10","volume":"14","author":"Lian","year":"2004","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1074\/jbc.M805432200_bib11","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1359\/jbmr.1997.12.10.1606","volume":"12","author":"Hanada","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1074\/jbc.M805432200_bib12","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1359\/jbmr.1999.14.9.1522","volume":"14","author":"Gori","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"10.1074\/jbc.M805432200_bib13","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1634\/stemcells.22-5-849","volume":"22","author":"Etheridge","year":"2004","journal-title":"Stem Cells."},{"key":"10.1074\/jbc.M805432200_bib14","doi-asserted-by":"crossref","first-page":"33132","DOI":"10.1074\/jbc.M500608200","volume":"280","author":"Gaur","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M805432200_bib15","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1210\/en.2005-0303","volume":"146","author":"Osyczka","year":"2005","journal-title":"Endocrinology."},{"key":"10.1074\/jbc.M805432200_bib16","doi-asserted-by":"crossref","first-page":"9645","DOI":"10.1074\/jbc.275.13.9645","volume":"275","author":"Jaiswal","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M805432200_bib17","doi-asserted-by":"crossref","first-page":"14443","DOI":"10.1074\/jbc.M010021200","volume":"276","author":"Lai","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M805432200_bib18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1083\/jcb.200401138","volume":"166","author":"Fujita","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M805432200_bib19","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1126\/science.1107627","volume":"308","author":"Kratchmarova","year":"2005","journal-title":"Science."},{"key":"10.1074\/jbc.M805432200_bib20","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1083\/jcb.200610046","volume":"176","author":"Ge","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M805432200_bib21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1677\/erc.0.0070165","volume":"7","author":"Powers","year":"2000","journal-title":"Endocr. Relat. Cancer."},{"key":"10.1074\/jbc.M805432200_bib22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cytogfr.2005.01.007","volume":"16","author":"Dailey","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1074\/jbc.M805432200_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cytogfr.2005.02.003","volume":"16","author":"Ornitz","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1074\/jbc.M805432200_bib24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-1119(03)00748-0","volume":"316","author":"Marie","year":"2003","journal-title":"Gene."},{"key":"10.1074\/jbc.M805432200_bib25","doi-asserted-by":"crossref","first-page":"4456","DOI":"10.1210\/endo.138.10.5425","volume":"138","author":"Martin","year":"1997","journal-title":"Endocrinology."},{"key":"10.1074\/jbc.M805432200_bib26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S8756-3282(98)00087-8","volume":"23","author":"Pri-Chen","year":"1998","journal-title":"Bone."},{"key":"10.1074\/jbc.M805432200_bib27","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1172\/JCI8641","volume":"105","author":"Montero","year":"2000","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M805432200_bib28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cytogfr.2005.01.001","volume":"16","author":"Eswarakumar","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1074\/jbc.M805432200_bib29","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1128\/MCB.16.3.977","volume":"16","author":"Mohammadi","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M805432200_bib30","doi-asserted-by":"crossref","first-page":"6074","DOI":"10.1073\/pnas.111114298","volume":"98","author":"Ong","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M805432200_bib31","doi-asserted-by":"crossref","first-page":"36181","DOI":"10.1074\/jbc.M206057200","volume":"277","author":"Xiao","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M805432200_bib32","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1074\/jbc.M203750200","volume":"278","author":"Kim","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M805432200_bib33","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1101\/gad.990702","volume":"16","author":"Ornitz","year":"2002","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M805432200_bib34","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/ajmg.10775","volume":"112","author":"Wilkie","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"10.1074\/jbc.M805432200_bib35","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/jcp.20760","volume":"209","author":"Ling","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"10.1074\/jbc.M805432200_bib36","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI119886","volume":"101","author":"Lomri","year":"1998","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M805432200_bib37","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S0002-9440(10)65401-6","volume":"154","author":"Fragale","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.M805432200_bib38","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1359\/jbmr.2001.16.5.832","volume":"16","author":"Lemonnier","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1074\/jbc.M805432200_bib39","doi-asserted-by":"crossref","first-page":"36259","DOI":"10.1074\/jbc.M402469200","volume":"279","author":"Kaabeche","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M805432200_bib40","doi-asserted-by":"crossref","first-page":"45926","DOI":"10.1074\/jbc.M404824200","volume":"279","author":"Tanimoto","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M805432200_bib41","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/jcp.20148","volume":"202","author":"Baroni","year":"2005","journal-title":"J. Cell. Physiol."},{"key":"10.1074\/jbc.M805432200_bib42","doi-asserted-by":"crossref","first-page":"18623","DOI":"10.1074\/jbc.273.29.18623","volume":"273","author":"Favata","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M805432200_bib43","doi-asserted-by":"crossref","first-page":"8319","DOI":"10.1073\/pnas.90.18.8319","volume":"90","author":"Pag\u00e9s","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M805432200_bib44","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/1097-4644(20010401)81:1<23::AID-JCB1021>3.0.CO;2-H","volume":"81","author":"Ahdjoudj","year":"2001","journal-title":"J. Cell. Biochem."},{"key":"10.1074\/jbc.M805432200_bib45","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0003-2697(86)90258-7","volume":"156","author":"Laughton","year":"1986","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M805432200_bib46","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cytogfr.2005.02.005","volume":"16","author":"van Bezooijen","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1074\/jbc.M805432200_bib47","first-page":"325","volume":"5","author":"Rios","year":"2005","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"10.1074\/jbc.M805432200_bib48","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ng2096","volume":"39","author":"Shukla","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M805432200_bib49","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/hmg\/7.9.1475","volume":"7","author":"Anderson","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M805432200_bib50","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1073\/pnas.121183798","volume":"98","author":"Ibrahimi","year":"2001","journal-title":"Proc Natl Acad Sci U. S. A."},{"key":"10.1074\/jbc.M805432200_bib51","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1083\/jcb.149.6.1297","volume":"149","author":"Mansukhani","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M805432200_bib52","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.yexcr.2004.03.032","volume":"297","author":"Debiais","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.M805432200_bib53","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/S0002-9440(10)64139-9","volume":"158","author":"Lemonnier","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.M805432200_bib54","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1083\/jcb.200409182","volume":"168","author":"Mansukhani","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M805432200_bib55","doi-asserted-by":"crossref","first-page":"12555","DOI":"10.1073\/pnas.0405031101","volume":"101","author":"Eswarakumar","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M805432200_bib56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S8756-3282(03)00222-9","volume":"33","author":"Chen","year":"2003","journal-title":"Bone."},{"key":"10.1074\/jbc.M805432200_bib57","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1242\/dev.01914","volume":"132","author":"Wang","year":"2005","journal-title":"Development."},{"key":"10.1074\/jbc.M805432200_bib58","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.bone.2007.11.019","volume":"42","author":"Yin","year":"2008","journal-title":"Bone."},{"key":"10.1074\/jbc.M805432200_bib59","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1016\/S0142-9612(02)00618-X","volume":"24","author":"Bensa\u00efd","year":"2003","journal-title":"Biomaterials."},{"key":"10.1074\/jbc.M805432200_bib60","first-page":"5357","volume":"63","author":"Pratap","year":"2003","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M805432200_bib61","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1089\/scd.2006.0044","volume":"16","author":"Woei","year":"2007","journal-title":"Stem Cells Dev."},{"key":"10.1074\/jbc.M805432200_bib62","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/pmic.200500289","volume":"6","author":"Kim","year":"2006","journal-title":"Proteomics."},{"key":"10.1074\/jbc.M805432200_bib63","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/jcb.21112","volume":"100","author":"Richardson","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"10.1074\/jbc.M805432200_bib64","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1242\/jcs.02436","volume":"118","author":"Rucci","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M805432200_bib65","doi-asserted-by":"crossref","first-page":"7578","DOI":"10.1128\/MCB.24.17.7578-7597.2004","volume":"24","author":"Gatesman","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M805432200_bib66","doi-asserted-by":"crossref","first-page":"7194","DOI":"10.1074\/jbc.M409212200","volume":"280","author":"Pula","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M805432200_bib67","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/1097-4644(20010401)81:1<68::AID-JCB1024>3.0.CO;2-S","volume":"81","author":"Debiais","year":"2001","journal-title":"J. Cell. Biochem."},{"key":"10.1074\/jbc.M805432200_bib68","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bone.2003.09.007","volume":"34","author":"Longo","year":"2004","journal-title":"Bone."},{"key":"10.1074\/jbc.M805432200_bib69","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jcp.20896","volume":"211","author":"Tang","year":"2007","journal-title":"J. Cell. Physiol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820709488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820709488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M805432200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T08:10:22Z","timestamp":1641370222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820709488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":69,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0021925820709488"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m805432200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}